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Professor",{"facility":613,"status":38,"city":614,"state":615,"zip":616,"country":42,"countryCode":43,"cosmosGeoPoint":617,"geoPoint":621,"contacts":622},"Univerity Hospital Schleswig-Holstein","Lübeck","Schleswig-Holstein","23562",{"type":45,"coordinates":618},[619,620],10.68729,53.86893,{"lat":620,"lon":619},[623],{"name":624,"role":28,"phone":10,"phoneExt":10,"email":10},"Axel Merseburger, Professor",{"facility":20,"status":38,"city":626,"state":627,"zip":628,"country":42,"countryCode":43,"cosmosGeoPoint":629,"geoPoint":633,"contacts":634},"Jena","Thuringia","07747",{"type":45,"coordinates":630},[631,632],11.5899,50.92878,{"lat":632,"lon":631},[635],{"name":19,"role":28,"phone":10,"phoneExt":10,"email":10},{"type":637,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[639,642],{"name":640,"class":641},"Novartis Pharmaceuticals","INDUSTRY",{"name":643,"class":641},"AstraZeneca","100580278","procare---prostate-cancer-real-world-evidence-registry-100580278",false,"NCT06835218","PROCARE - PROstate Cancer Real World Evidence Registry","PROstate CAncer Real World Evidence Registry: RECURRENT AND METASTATIC PROSTATE CANCER","PROCARE","Inclusion Criteria:\n\n* Adult prostate cancer patients (age ≥18 years).\n* Diagnosis at time of study inclusion Cohort 1: biochemical recurrence (BCR) after local curative intended treatment (e.g. radical prostatectomy, radiotherapy of the prostate or combination thereof) Cohort 2: non-metastatic castration-resistant prostate cancer (nmCRPC) or Cohort 3: metastatic hormone sensitive prostate cancer (mHSPC) or Cohort 4: metastatic castration-resistant prostate cancer (mCRPC) (irrespective of treatment choice, treatment line)\n* Patients who will receive a new line of systemic therapy at the time of study entry or up to 4 weeks thereafter. Regarding Cohort 4 this includes patients with a new diagnosis of mCRPC (=first line mCRPC) after either treatment for mHSPC or non-metastatic CRPC as well as patients with prior mCRPC treatments (2nd, 3rd, … line).\n* For Cohorts 1, 2 and 3: Disease proven by clinical measures (i.e. standard imaging) to be either unsuitable for local salvage treatment (e.g. surgery, radiotherapy) or local treatment is declined by the patient.\n* Patients, who are able and willing to sign the informed consent form\n\nExclusion Criteria:\n\n• Patients who are not eligible for observation due to severe comorbidities or unavailability according to the treating physician","MALE","18 Years",{"count":655,"type":656},5000,"ESTIMATED","OBSERVATIONAL","The aim of this registry study with long-term follow-up is to record the course of therapy and disease in patients with recurrent and metastatic prostate cancer. The following patient groups are planned:\n\n* Patients with a recurrence of PSA after surgical removal or radiation of the prostate due to prostate cancer; so-called PSA recurrence (relapse) or biochemical recurrence.\n* Patients with a PSA recurrence who have received treatment by hormone deprivation therapy (so-called androgen deprivation) and in whom the PSA value has nevertheless risen again without spreading to other organs or parts of the body, so-called non-metastatic castration-resistant prostate cancer.\n* Patients with proven spread to other organs or parts of the body (= metastases, e.g. in the bone) without hormone deprivation therapy having been initiated, so-called metastatic hormone-sensitive prostate cancer.\n* Patients with prostate cancer and spread to other organs or parts of the body (= metastases) in whom the tumor disease has progressed despite hormone withdrawal treatment (e.g. as evidenced by an increase in PSA), so-called metastatic castration-refractory prostate cancer.\n\nThese four groups of patients are enrolled and observed independently of each other at different time periods.",[660,661,662,663,664],"Prostate Cancer","Biochemical Recurrence of Malignant Neoplasm of Prostate","Non-metastatic Castration-resistant Prostate Cancer","Metastatic Hormone-sensitive Prostate Cancer (mHSPC)","Metastatic Castration-resistant Prostate Cancer",[666],"prostate, cancer, metastatic, systemic therapy","2026-03-10",{"date":669,"type":670},"2026-03-12","ACTUAL",{"date":672,"type":670},"2024-01-29",{"date":674,"type":656},"2032-12-31",{"name":5,"class":6},53]