[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629792":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":42,"responsibleParty":117,"collaborators":26,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":121,"sex":127,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":26,"studyType":133,"phases":134,"briefSummary":136,"conditions":137,"keywords":141,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":156},{"fullName":5,"class":6},"Fondazione del Piemonte per l'Oncologia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Progel Group (PG)","EXPERIMENTAL","Fissure completion with mechanical staplers followed by application of Progel Platinum sealant along the fissure completion line.",[13],"Device: Progel Platinum",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Treatment Group (ST)","ACTIVE_COMPARATOR","Fissure completion with mechanical staplers alone, according to current standard practice.",[19],"Procedure: Mechanical Stapling",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Progel Platinum","Progel Platinum surgical sealant applied to the completed fissure line after stapled fissure completion during VATS upper or lower lobectomy",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Mechanical Stapling","Standard mechanical stapling used for fissure completion during VATS upper or lower lobectomy.",[15],[33,38],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Andrea Droghetti MD","CONTACT","00390119933850","andrea.droghetti@ircc.it",{"name":39,"role":35,"phone":40,"phoneExt":26,"email":41},"Annamaria Nuzzo PHD","00390119933844","annamaria.nuzzo@ircc.it",[43,61,73,84,95,106],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Unità di Chirurgia Toracica Oncologica","RECRUITING","Candiolo","Torino","10060","Italy","IT",{"type":52,"coordinates":53},"Point",[54,55],7.59812,44.95858,{"lat":55,"lon":54},[58],{"name":59,"role":35,"phone":60,"phoneExt":26,"email":37},"Andrea Droghetti, MD","+390119933850",{"facility":62,"status":63,"city":64,"state":26,"zip":26,"country":49,"countryCode":50,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Ospedale centrale di Bolzano, Chirurgia Toracica e Vascolare","NOT_YET_RECRUITING","Bolzano",{"type":52,"coordinates":66},[67,68],11.33982,46.49067,{"lat":68,"lon":67},[71],{"name":72,"role":35,"phone":26,"phoneExt":26,"email":26},"Francesco Zaraca",{"facility":74,"status":63,"city":75,"state":26,"zip":26,"country":49,"countryCode":50,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Azienda Ospedaliero-Universitaria Careggi","Florence",{"type":52,"coordinates":77},[78,79],11.24626,43.77925,{"lat":79,"lon":78},[82],{"name":83,"role":35,"phone":26,"phoneExt":26,"email":26},"Alessandro Gonfiotti",{"facility":85,"status":63,"city":86,"state":26,"zip":26,"country":49,"countryCode":50,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico","Milan",{"type":52,"coordinates":88},[89,90],12.59836,42.78235,{"lat":90,"lon":89},[93],{"name":94,"role":35,"phone":26,"phoneExt":26,"email":26},"Mario Nosotti",{"facility":96,"status":63,"city":97,"state":26,"zip":26,"country":49,"countryCode":50,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Irccs Ismett","Palermo",{"type":52,"coordinates":99},[100,101],13.3636,38.1166,{"lat":101,"lon":100},[104],{"name":105,"role":35,"phone":26,"phoneExt":26,"email":26},"Alessandro Bertani",{"facility":107,"status":63,"city":108,"state":26,"zip":26,"country":49,"countryCode":50,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Azienda Ospedaliera-Universitaria Pisana","Pisa",{"type":52,"coordinates":110},[111,112],10.4036,43.70853,{"lat":112,"lon":111},[115],{"name":116,"role":35,"phone":26,"phoneExt":26,"email":26},"Marcello Carlo Ambrogi",{"type":118,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100629792","progel-platinum-for-air-leak-reduction-after-vats-lobectomy-for-nsclc-100629792",false,"NCT07479277","Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC","A Multicenter, Randomized, Parallel-Group Trial Evaluating Progel Platinum Added to Mechanical Stapling Versus Mechanical Stapling Alone in Patients Undergoing VATS Upper or Lower Lobectomy for Non-Small Cell Lung Cancer","E-SEAL","Inclusion Criteria:\n\n* Age ≥18 years\n* Written informed consent\n* Planned VATS upper or lower lobectomy for NSCLC\n* Minimally invasive thoracoscopic approach\n* Middle lobectomy excluded\n\nExclusion Criteria:\n\n* Induction radiochemotherapy or chemo-immunotherapy\n* Severe COPD: GOLD 3 or higher\n* Sleeve resection or extended resection involving other lobes\u002Fchest wall\u002Fpericardium, etc.\n* Albumin intolerance\u002Fallergy\n* Renal insufficiency\n* Redo surgery\n* Use of sealants\u002Fadhesives other than the study approach\n* Expected extensive pleural adhesions","ALL","18 Years","99 Years",{"count":131,"type":132},160,"ESTIMATED","INTERVENTIONAL",[135],"NA","This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.",[138,139,140],"Non-Small Cell Lung Cancer","Postoperative Air Leak","NSCLC",[138,140,142,143,144,23,145,146],"VATS Lobectomy","Postoperative air leak","Pleural drainage","Surgical sealant","Thoracic surgery","2026-03-16",{"date":149,"type":150},"2026-03-18","ACTUAL",{"date":152,"type":150},"2026-02-27",{"date":154,"type":132},"2027-12-31",{"name":5,"class":6},6]