[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100453050":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":23,"locations":34,"responsibleParty":55,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"McGill University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Acute stroke patients",null,"12 weekly evaluations starting within the first week post-stroke. Follow-up assessment at week 16. MRI at week 6.",[13,17,21],{"name":14,"affiliation":15,"role":16},"Theodore Wein, MD","Montreal Neurological Institute","PRINCIPAL_INVESTIGATOR",{"name":18,"affiliation":19,"role":20},"Alexander Thiel, MD","Jewish General Hospital - McGill University","STUDY_CHAIR",{"name":22,"affiliation":5,"role":20},"Marie-Helene Boudrias, PT, PhD",[24,30],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Mindy F. Levin, PT, PhD","CONTACT","450-688-9550","84371","mindy.levin@mcgill.ca",{"name":31,"role":26,"phone":27,"phoneExt":32,"email":33},"Alice Misana, PT","84655","alice.misana@mail.mcgill.ca",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Jewish General Hospital","RECRUITING","Montreal","Quebec","H3T 1E2","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-73.58781,45.50884,{"lat":47,"lon":46},[50],{"name":51,"role":26,"phone":52,"phoneExt":53,"email":54},"Sharon Shapiro","514-340-8222","22094","sshapiro@jgh.mcgill.ca",{"type":16,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Mindy F. Levin","Professor","100453050","prognosis-and-diagnosis-of-spasticity-in-acute-post-stroke-patients-100453050",false,"NCT05179473","Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients","Changing Practice: Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients: a Pilot Study","Inclusion Criteria:\n\n* Acute stroke in Middle Cerebral Artery area resulting in hemiparesis.\n* Hemorrhagic or ischemic\n* Medically stable\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive disorders\n* Ataxia","ALL","18 Years","85 Years",{"count":69,"type":70},12,"ESTIMATED","OBSERVATIONAL","Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle muscles. However, despite its clinical relevance, the natural development of spasticity over the first 3 months after stroke is not clearly understood. Indeed, common clinical measures of spasticity such as the Modified Ashworth Scale (MAS) do not take into account the neurophysiological origin of spasticity and lack reliability and objectivity.\n\nThe objective of this study is to examine the natural history of the development of spasticity among patients with stroke over the first 3 months using a new neurophysiological measure (TSRT, the tonic stretch reflex threshold angle) and its velocity sensitivity (mu) in comparison to MAS and other common clinical tests. In addition, detailed brain imaging will be used to understand the relationship between damage to brain regions relevant to the development of spasticity and TSRT\u002Fmu values.\n\nIt is hypothesized that 1) TSRT\u002Fmu will indicate the presence of spasticity earlier than MAS\u002Fclinical tests; 2) TSRT\u002Fmu measures will be more closely related to motor impairments and activity limitations than MAS; 3) the lesion severity (identified by imaging) will be related to the change in TSRT\u002Fmu values.\n\nOutcomes will be measured in a pilot cohort of 12 patients hospitalized for first-ever stroke. Measurements will be taken at the bedside within the 1st week of the patient's admission and will be done once per week for 12 weeks with a follow-up at week 16. Brain Imaging will be done around the 6th week post-stroke.",[74,75,76,77],"Stroke, Acute","Stroke, Ischemic","Stroke Hemorrhagic","Spasticity as Sequela of Stroke",[79,80,81,82,83,84,85],"stroke","spasticity","imaging","prognosis","diagnosis","upper limb","lower limb","2025-05-30",{"date":88,"type":89},"2025-06-04","ACTUAL",{"date":91,"type":89},"2021-06-17",{"date":93,"type":70},"2025-12-30",{"name":5,"class":6},1]