[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593311":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":20,"locations":19,"responsibleParty":27,"collaborators":19,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":33,"sex":39,"minAge":40,"maxAge":19,"enrollmentInfo":41,"targetDuration":19,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":50,"overallStatus":57,"whyStopped":19,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":19},{"fullName":5,"class":6},"Clinica Mexico","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Inpatient Stroke confirmed","All participants diagnosed with acute ischemic stroke will undergo standard clinical evaluation and transcranial Doppler ultrasound within 24 hours of symptom onset. No interventions are assigned by the study. Clinical and hemodynamic data will be collected to assess prognostic associations with short-term outcomes. All patients are managed according to routine care protocols determined by the attending medical team.",[12],"Diagnostic Test: Transcranial Doppler Ultrasound",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Transcranial Doppler Ultrasound","A non-invasive bedside diagnostic procedure used to measure cerebral blood flow velocities and pulsatility index in intracranial arteries, primarily the middle cerebral artery (MCA). The test is performed within the first 24 hours of symptom onset using standard ultrasound equipment with a 2-MHz probe. The data collected is used solely for prognostic evaluation and does not influence treatment decisions.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"JOSE IVAN RODRIGUEZ DE MOLINA SERRANO, MD, MSc, Ph, Crit Care sp","CONTACT","878 782 12 89","208","jefe.urgencias@clinicamexico.com",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Jose Ivan Rodriguez de Molina Serrano","Head of Research and Medical Education Clinica Mexico","100593311","prognostic-value-of-transcranial-doppler-ultrasound-in-the-clinical-evolution-of-patients-with-acute-ischemic-stroke-the-trade-ais-study-100593311",false,"NCT07004790","Prognostic Value of Transcranial Doppler Ultrasound in the Clinical Evolution of Patients With Acute Ischemic Stroke. The TRADE-AIS Study","Prognostic Value of Transcranial Doppler Ultrasound in the Clinical Evolution of Patients With Acute Ischemic Stroke: A Prospective Observational Study","TRADE-AIS","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinical diagnosis of acute ischemic stroke\n* Onset of symptoms ≤ 24 hours before admission\n* Underwent or will undergo transcranial Doppler ultrasound within 24 hours of symptom onset\n* Able to provide informed consent or consent obtained from a legal representative\n\nExclusion Criteria:\n\n* Evidence of intracerebral hemorrhage on imaging\n* Inadequate temporal acoustic window for transcranial Doppler\n* Intubated or hemodynamically unstable prior to Doppler evaluation\n* Known diagnosis of neurodegenerative disease significantly affecting baseline neurological function (e.g., advanced dementia, Parkinson's disease)\n* Refusal to participate or withdrawal of consent","ALL","18 Years",{"count":42,"type":43},50,"ESTIMATED","INTERVENTIONAL",[46],"NA","This prospective observational study aims to determine whether specific parameters measured by transcranial Doppler ultrasound (TCD) can predict clinical outcomes in patients with acute ischemic stroke (AIS). The primary objective is to evaluate the association between middle cerebral artery (MCA) flow velocities and short-term neurological improvement. Secondary outcomes include the presence of collateral flow and flow patterns in relation to functional recovery measured by NIHSS and modified Rankin Scale (mRS) scores.",[49],"Stroke",[51,52,53,54,55,56],"stroke","transcranial doppler","Prognosis","Middle Cerebral Artery","Cerebral Hemodynamics","Mexico","NOT_YET_RECRUITING","2025-09-13",{"date":60,"type":61},"2025-09-16","ACTUAL",{"date":63,"type":43},"2026-08-01",{"date":65,"type":43},"2027-08-30",{"name":29,"class":6}]