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Van Veen, MD","CONTACT","+31628138839",[19,31,39,47,55,63,71,79,87,95,103],{"facility":20,"status":21,"city":22,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":10},"Noordwest Ziekenhuisgroep","RECRUITING","Alkmaar","Netherlands","NL",{"type":26,"coordinates":27},"Point",[28,29],4.74861,52.63167,{"lat":29,"lon":28},{"facility":32,"status":21,"city":33,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":34,"geoPoint":38,"contacts":10},"Gelre Ziekenhuis","Apeldoorn",{"type":26,"coordinates":35},[36,37],5.96944,52.21,{"lat":37,"lon":36},{"facility":40,"status":21,"city":41,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":42,"geoPoint":46,"contacts":10},"Albert Schweitzer Ziekenhuis","Dordrecht",{"type":26,"coordinates":43},[44,45],4.67361,51.81,{"lat":45,"lon":44},{"facility":48,"status":21,"city":49,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":50,"geoPoint":54,"contacts":10},"Catharina Ziekenhuis","Eindhoven",{"type":26,"coordinates":51},[52,53],5.47778,51.44083,{"lat":53,"lon":52},{"facility":56,"status":21,"city":57,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":58,"geoPoint":62,"contacts":10},"Treant Ziekenhuis","Emmen",{"type":26,"coordinates":59},[60,61],6.90694,52.77917,{"lat":61,"lon":60},{"facility":64,"status":21,"city":65,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":66,"geoPoint":70,"contacts":10},"Admiraal de Ruyter Ziekenhuis","Goes",{"type":26,"coordinates":67},[68,69],3.88889,51.50417,{"lat":69,"lon":68},{"facility":72,"status":21,"city":73,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":74,"geoPoint":78,"contacts":10},"Tjongerschans Ziekenhuis","Heerenveen",{"type":26,"coordinates":75},[76,77],5.91854,52.95929,{"lat":77,"lon":76},{"facility":80,"status":21,"city":81,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":82,"geoPoint":86,"contacts":10},"Zuyderland Medisch","Heerlen",{"type":26,"coordinates":83},[84,85],5.98154,50.88365,{"lat":85,"lon":84},{"facility":88,"status":21,"city":89,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":90,"geoPoint":94,"contacts":10},"Medisch Centrum Leeuwarden","Leeuwarden",{"type":26,"coordinates":91},[92,93],5.80973,53.20271,{"lat":93,"lon":92},{"facility":96,"status":21,"city":97,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":98,"geoPoint":102,"contacts":10},"Canisius Wilhelmina Ziekenhuis","Nijmegen",{"type":26,"coordinates":99},[100,101],5.85278,51.8425,{"lat":101,"lon":100},{"facility":104,"status":21,"city":105,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":106,"geoPoint":110,"contacts":10},"Antonius Ziekenhuis Sneek","Sneek",{"type":26,"coordinates":107},[108,109],5.6589,53.03297,{"lat":109,"lon":108},{"type":112,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100581055","promoting-optimal-treatment-choices-in-neonates-with-suspected-early-onset-sepsis-100581055",false,"NCT06845332","Promoting Optimal Treatment Choices in Neonates With Suspected Early-Onset Sepsis","PROTeCt-NEO: Promoting Optimal Treatment Choices Through Implementation of Antibiotic Stewardship Strategies in Neonates With Suspected Early-Onset Sepsis","PrOTeCt-NEO","Inclusion Criteria:\n\n* Neonates born at 34 weeks of gestation or later\n* 0-3 days old\n\nExclusion Criteria:\n\n* stillborn neonates","ALL","3 Days",{"count":124,"type":125},55000,"ESTIMATED","OBSERVATIONAL","In this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral switch therapy. These strategies have been proven to be effective and safe and are already applied in several Dutch hospitals. However, this is not the case for all hospitals, leading to significant variations in clinical practice. To facilitate the translation of evidence into practice, active implementation will take place.\n\nThe primary research design is a prospective implementation study, using a multicenter, non-randomized pre-post design. The aim is to assess the impact of implementing a bundle of antibiotic stewardship interventions (including the EOS calculator, PCT-guided therapy and iv-to-oral switch therapy) in Dutch hospitals, using a multicomponent implementation strategy, on both clinical and implementation outcomes, with a particular focus on evaluating the employed implementation strategies.\n\nA combination of qualitative and quantitative research methods will be used to assess outcomes. Quantitative clinical data from neonates in the pre- and post-implementation periods will be retrospectively collected by the Business Intelligence units of participating hospitals and anonymized before being provided to the central research team. Qualitative data will be gathered through focus groups, interviews, and surveys.",[129],"Early-onset Sepsis",[131,132,133,134,135,136],"early-onset sepsis","neonatal sepsis","early-onset sepsis calculator","PCT-guided therapy","iv-to-oral switch therapy","implementation","2025-09-18",{"date":139,"type":140},"2025-09-19","ACTUAL",{"date":142,"type":140},"2024-01-01",{"date":144,"type":125},"2026-06-01",{"name":5,"class":6},11]