[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614262":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":62,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":20,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"LIFUP group","EXPERIMENTAL","Participants will receive low-intensity focused ultrasound intervention. Participants are also anticipated to undergo advanced MRI and EEG. Surrogate decision makers (family members) and recovered patients will undergo a semi-structured interview.",[13],"Device: Low-intensity focused ultrasound",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Low-intensity focused ultrasound","Low-intensity focused ultrasound pulsations (LIFUP) will be delivered to the brain, along with advanced MRI and EEG. Surrogate decision makers (family members) and recovered patients will undergo a semi-structured interview.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Michael Young, MD, MPhil","CONTACT","410-808-1196","michael.young@mgh.harvard.edu",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Jason Lew, DO","617-724-9247","jlew3@mgb.org",[32,50],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Massachusetts General Hospital (The General Hospital Corp.)","RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-71.05977,42.35843,{"lat":44,"lon":43},[47,48],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"name":23,"role":49,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"facility":51,"status":34,"city":52,"state":36,"zip":53,"country":38,"countryCode":39,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Spaulding Rehabilitation Hospital Corporation, Inc.","Cambridge","02138",{"type":41,"coordinates":55},[56,57],-71.10561,42.3751,{"lat":57,"lon":56},[60,61],{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},{"name":28,"role":49,"phone":20,"phoneExt":20,"email":20},{"type":49,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Michael J. Young, M.D., M.Phil","PI",[66],{"name":67,"class":68},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100614262","promoting-recovery-after-brain-injury-using-focused-ultrasound-100614262",false,"NCT07277309","Promoting Recovery After Brain Injury Using Focused Ultrasound","ReBOUND","Inclusion Criteria:\n\n* Brain injury resulting in DoC diagnosis, following international guidelines\n* At least 18 years of age\n* Legally authorized representative (surrogate) available to consent\n\nExclusion Criteria:\n\n* History of neurological disorder other than the brain injury\n* Metal implant or other condition precluding MRI\n* Manifest continuous spontaneous movement (which would prevent safe\u002Fsuccessful MRI)\n* Participation in concurrent therapeutic study\n* Pregnancy","ALL","18 Years","79 Years",{"count":80,"type":81},36,"ESTIMATED","INTERVENTIONAL",[84],"NA","The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.",[87,88],"Consciousness Disorders","Disorders of Consciousness Due to Severe Brain Injury",[90,91,92,93,94,95,96,97,98,99],"Disorder of Consciousness","Vegetative State","Minimally Conscious State","Minimally Conscious State Plus","Minimally Conscious State Minus","Traumatic Brain Injury","CVA (Cerebrovascular Accident)","Anoxia, Brain","Thalamic Infarction","Coma; Prolonged","2026-06-12",{"date":102,"type":103},"2026-06-15","ACTUAL",{"date":105,"type":103},"2026-05-26",{"date":107,"type":81},"2029-07",{"name":5,"class":6},2]