[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642609":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":59,"centralContacts":63,"locations":73,"responsibleParty":104,"collaborators":107,"id":110,"slug":111,"hasResults":112,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":112,"sex":118,"minAge":119,"maxAge":11,"enrollmentInfo":120,"targetDuration":11,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":135,"whyStopped":11,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","EXPERIMENTAL",null,[13,14,15,16,17,18,19],"Behavioral: AWARD advice","Behavioral: Brief leaflet on health warning and smoking cessation","Behavioral: Referral card","Behavioral: Self-help smoking cessation booklet","Behavioral: Personalized active referral","Behavioral: 12 weeks of chatbot-based instant messaging support","Behavioral: Reminder messages",{"label":21,"type":22,"description":11,"interventionNames":23},"Control group","ACTIVE_COMPARATOR",[13,14,15,16,17,24,19],"Behavioral: 12 weeks of human-led instant messaging support",[26,31,35,39,43,47,51,55],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"BEHAVIORAL","AWARD advice","A brief (30-60 seconds) face-to-face or remote smoking cessation advice delivered using the validated AWARD model: Ask about smoking history; Warn about high health risks (accompanied by a health warning leaflet); Advise quitting as soon as possible and setting a quit date (to qualify for contest prizes); Refer to smoking cessation services using a referral card; Do it again - repeat the intervention at each follow-up, encouraging re-quitting after relapse or relapse prevention after success.",[21,9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"Brief leaflet on health warning and smoking cessation","A two-sided, colour-printed A4 leaflet covering: (1) absolute risk of death from smoking; (2) full list of diseases caused by active and second-hand smoking; (3) ten pictorial warnings of health consequences on one page for maximum impact; (4) benefits of smoking cessation; and (5) simple encouraging messages to quit.",[21,9],{"type":27,"name":36,"description":37,"armGroupLabels":38,"otherNames":11},"Referral card","A three-folded card containing brief information and highlights of existing smoking cessation services in Hong Kong, contact methods, motivational messages, and strong supporting slogans.",[21,9],{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":11},"Self-help smoking cessation booklet","A generic booklet provided covering: benefits of quitting, smoking-related diseases, methods to quit, how to handle withdrawal symptoms, a quitting declaration, and other practical tips.",[21,9],{"type":27,"name":44,"description":45,"armGroupLabels":46,"otherNames":11},"Personalized active referral","Smokers will be introduced to various SC services in Hong Kong (via the referral card) and motivated to use them. Well-trained SC ambassadors will assist smokers in choosing their favourite or most convenient type of service. Research staff will assist participants in booking or re-booking the SC services at the 1- and 2-month follow-ups (after very brief questionnaire surveys). Participants' contact information will be forwarded to SC service providers within 7 days, and providers are expected to contact participants within 1-2 weeks. Research staff will also monitor participants' use of SC services at each follow-up (1-, 2-, 3-, and 6-month) and, at the 1- and 2-month follow-ups, assist participants in booking or rebooking appointments if necessary. Investigators shall liaise with existing service providers and seek their assistance in promptly supporting our smokers.",[21,9],{"type":27,"name":48,"description":49,"armGroupLabels":50,"otherNames":11},"12 weeks of chatbot-based instant messaging support","Participants in the intervention group will receive 12 weeks of instant messaging support delivered by an LLM-based chatbot (GPT-4o or newer) on WhatsApp, supporting text and audio input. Using prompt engineering, agent techniques, and Retrieval-Augmented Generation, the chatbot delivers theory-based 5As\u002F5Rs-structured interventions alongside freeform, on-demand support, with engagement features including personalisation, proactive check-ins, and interactive Quick Commands.",[9],{"type":27,"name":52,"description":53,"armGroupLabels":54,"otherNames":11},"12 weeks of human-led instant messaging support","Participants in the control group will receive 12 weeks of instant messaging support delivered by a trained human counsellor via WhatsApp. Using the same theoretical frameworks as the chatbot intervention, the counsellor will provide real-time behavioural and psychosocial support grounded in the 5As\u002F5Rs models, Motivational Interviewing (MI), and evidence-based Behaviour Change Techniques (BCTs). The support will be personalised according to each participant's sociodemographic characteristics, smoking patterns, quit intentions, and plans.",[21],{"type":27,"name":56,"description":57,"armGroupLabels":58,"otherNames":11},"Reminder messages","WhatsApp messages on follow-up survey reminders.",[21,9],[60],{"name":61,"affiliation":5,"role":62},"Man Ping Wang","PRINCIPAL_INVESTIGATOR",[64,69],{"name":65,"role":66,"phone":67,"phoneExt":11,"email":68},"Man Ping Wang, PhD","CONTACT","+852 3917 6636","mpwang@hku.hk",{"name":70,"role":66,"phone":71,"phoneExt":11,"email":72},"Yilan Wu","+852 56497578","visspalan@connect.hku.hk",[74],{"facility":75,"status":11,"city":76,"state":76,"zip":77,"country":76,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"Hong Kong Council on Smoking and Health (COSH)","Hong Kong","999077","HK",{"type":80,"coordinates":81},"Point",[82,83],114.17469,22.27832,{"lat":83,"lon":82},[86,87,88,89,92,94,96,98,100,102],{"name":65,"role":66,"phone":67,"phoneExt":11,"email":68},{"name":70,"role":66,"phone":71,"phoneExt":11,"email":72},{"name":61,"role":62,"phone":11,"phoneExt":11,"email":11},{"name":90,"role":91,"phone":11,"phoneExt":11,"email":11},"Shengzhi Zhao, PhD","SUB_INVESTIGATOR",{"name":93,"role":91,"phone":11,"phoneExt":11,"email":11},"Ziqiu Guo, PhD",{"name":95,"role":91,"phone":11,"phoneExt":11,"email":11},"Yilan Wu, MGH",{"name":97,"role":91,"phone":11,"phoneExt":11,"email":11},"Mengyao Li, Mphil",{"name":99,"role":91,"phone":11,"phoneExt":11,"email":11},"Xiaoyun Xie, MPH",{"name":101,"role":91,"phone":11,"phoneExt":11,"email":11},"Patrick IP, MD, PhD",{"name":103,"role":91,"phone":11,"phoneExt":11,"email":11},"Ning Huang, PhD",{"type":62,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Prof. Wang Man-Ping","Professor",[108],{"name":109,"class":6},"Hong Kong Council on Smoking and Health","100642609","promoting-smoking-cessation-in-the-community-via-quit-to-win-contest-2026-engagement-focused-genai-based-chatbot-for-real-time-smoking-cessation-support-100642609",false,"NCT07649044","Promoting Smoking Cessation in the Community Via \"Quit to Win\" Contest 2026: Engagement-Focused GenAI-based Chatbot for Real-Time Smoking Cessation Support","Building Capacity and Promoting Smoking Cessation in the Community Via \"Quit to Win\" Contest 2026: Real-time Smoking Cessation Instant Messaging Support Using a Engagement-Focused Large Language Model (LLM)-Based Chatbot","QTW2026","Inclusion Criteria:\n\n1. Hong Kong residents aged 18 years or above\n2. Smoke at least one cigarette (including heated tobacco products) per day or use an e-cigarette daily in the preceding 3 months\n3. Able to communicate in Cantonese (including reading and writing Chinese)\n4. Saliva cotinine level ≥30 ng\u002FmL\n5. Intention to quit or reduce smoking\n6. Have WhatsApp installed\n7. Able to use WhatsApp for communication\n\nExclusion Criteria:\n\n1. Smokers who have communication barriers (either physical or cognitive)\n2. Smokers who are currently participating in other smoking cessation programs or services","ALL","18 Years",{"count":121,"type":122},998,"ESTIMATED","INTERVENTIONAL",[125],"NA","The goal of this trial is to learn if chatbot-based instant messaging works to help smoking cessation in general adult smokers. It will also learn about the experience, attitude, and perception of using an LLM-based chatbot. The main questions it aims to answer are:\n\n1. Will an engagement-focused LLM-based chatbot smoking cessation intervention have a non-inferior validated abstinence rate than the control group?\n2. Will an LLM-based chatbot smoking cessation intervention have a non-inferior self-reported abstinence rate, smoking reduction rate, and smoking cessation services use rate than the control group?\n\nResearchers will compare an LLM-based chatbot smoking-cessation intervention to a human-led instant messaging support group (brief advice based on AWARD and personalised active referral) to determine whether chatbot-based instant messaging support promotes smoking cessation.\n\nParticipants in the intervention group will receive:\n\n1. AWARD advice\n2. Personalised active referral\n3. 12 weeks of chatbot-based instant messaging support (via WhatsApp)",[128],"Smoking Cessation",[130,131,132,133,134],"Large-language model","Chatbot","Smoking cessation","Digital health","Engagement","NOT_YET_RECRUITING","2026-06-26",{"date":138,"type":139},"2026-06-30","ACTUAL",{"date":141,"type":122},"2026-06-27",{"date":143,"type":122},"2028-06-30",{"name":5,"class":6},1]