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confirmation by blood hormone levels (FSH and estradiol in premenopausal range as per local normal range) recommended)\n* Primary tumor diagnosis not older than three months prior to inclusion (primary diagnosis defined as date of initial tumor biopsy)\n* Estrogen- and\u002For progesterone-receptor-positive\u002FHER2 negative early breast cancer without any clinical signs of metastases\n* Adequate risk for recurrence:\n* intermediate clinical risk for recurrence, defined as (clinical in case of neoadjuvant treatment):\n* c\u002FpT1 and\n* c\u002FpN0 and\n* Ki-67 15-24% or\n* G2 or\n* patients, who do not meet these criteria but are at intermediate clinical risk for recurrence at investigator decision (e.g., very young age, low expression of hormone receptors, existing co-morbidities, familial cancer burden, etc.) can be included on individual decision basis or\n* high clinical risk for recurrence, defined as either (clinical in case of neoadjuvant treatment):\n* c\u002FpT2-4 or\n* c\u002FpN1 or\n* Ki-67 ≥25% or\n* G3\n* Low genomic risk of recurrence by MammaPrint® (tested on treatment naïve tumor specimen)\n* Luminal-type by BluePrint®\n* Treatment according to standard-of-care (e.g., AGO Guidelines) planned or started (until completion of local therapy the latest (including started or completed endocrine induction therapy), started, or planned adjuvant or neoadjuvant treatment)\n* Availability of untreated tumor material (core biopsy if preoperative endocrine therapy performed or neoadjuvant treatment intended or surgery specimen)\n* Capability to give written informed consent\n* Nodal positive patients will be accepted to the registry up to 25% of the genomic low\u002Fultralow-risk population (n=441).\n\nExclusion Criteria:\n\nPatients will not be eligible for the registry for any of the following reasons:\n\n* Any other genomic testing, besides MammaPrint®, has been performed on the tumor material\n* Medical or psychological conditions that would not permit the patient to sign informed consent\n* Legal incapacity or limited legal capacity\n* Current participation in any interventional clinical trial which tests anticancer drugs, immunotherapeutics, or antibody treatment for any type of neoplasm\n* Non-compliance of the patient","FEMALE","18 Years","60 Years",{"count":958,"type":959},1470,"ESTIMATED","10 Years","OBSERVATIONAL","There is only limited data for premenopausal patients in general, as well as for differences in the use of OFS in the subgroups of pre- and perimenopausal patients, respectively. 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