[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638009":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":24,"locations":30,"responsibleParty":55,"collaborators":17,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":17,"enrollmentInfo":68,"targetDuration":17,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":33,"whyStopped":17,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","Participants were randomized allocated to intervention group and receive piperacillin-tazobactam as prophylactic antibiotic before hepatobiliary surgery.",[13],"Drug: Piperacillin-tazobactam",{"label":15,"type":16,"description":17,"interventionNames":17},"Control group","NO_INTERVENTION",null,[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":17},"DRUG","Piperacillin-tazobactam","Participants were randomized allocated to intervention group and receive piperacillin-tazobactam as prophylactic antibiotic before hepatobiliary surgery. Participants in the cotrol group will receive cefuroxime for prophylactic antibiotic.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":17,"email":29},"Dayu Chen, Pharmacist in Charge, PharmD","CONTACT","+86-025-83106666-60924","cdy_pharmacy@njglyy.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Nanjing Drum Tower Hospital","RECRUITING","Nanjing","Jiangsu","210008","China","CN",{"type":40,"coordinates":41},"Point",[42,43],118.77778,32.06167,{"lat":43,"lon":42},[46,50,53],{"name":47,"role":27,"phone":48,"phoneExt":17,"email":49},"Yao Du, Pharmacist in Charge","+86-025-83106666-60910","dudu0083@126.com",{"name":51,"role":52,"phone":17,"phoneExt":17,"email":17},"Dayu Chen, PharmD","PRINCIPAL_INVESTIGATOR",{"name":54,"role":52,"phone":17,"phoneExt":17,"email":17},"Yao Du",{"type":52,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Chen Dayu","Pharmacist in Charge","100638009","prophylactic-antibiotics-in-preventing-surgical-site-infection-after-hepatobiliary-surgery-in-high-resistant-settings-100638009",false,"NCT07620223","Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings","Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings: A Randomized Clinical Trial","PASH","Inclusion Criteria:\n\n* Adult patients aged ≥18 years;\n* Deemed eligible for elective hepatobiliary surgery;\n* Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;\n* Capable of providing written informed consent.\n\nExclusion Criteria:\n\n* History of β-lactam allergy or hypersensitivity\n* Uncontrolled preoperative infection;\n* Current or recent (within the preceding month) systemic corticosteroid administration;\n* Severe hepatic or renal impairment;\n* Pregnancy or lactation;\n* Concurrent enrolment in another clinical trial;\n* Any other condition deemed by the investigator to render the patient unsuitable for study participation.","ALL","18 Years",{"count":69,"type":70},378,"ESTIMATED","INTERVENTIONAL",[73],"NA","To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.",[76,77],"Hepatobiliary Surgery","Prophylactic Antibiotics",[76,79,80,81],"Antimicrobial resistance","Prophylactic antibiotic","Surgical site infection","2026-05-27",{"date":84,"type":85},"2026-06-02","ACTUAL",{"date":87,"type":85},"2026-05-24",{"date":89,"type":70},"2029-01-31",{"name":5,"class":6},1]