[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622650":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":50,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":66,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Istanbul University - Cerrahpasa","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Group H",null,"High-Dose Propofol Group",{"label":13,"type":10,"description":14,"interventionNames":10},"Group L","Low-Dose Propofol Group",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Yasemin Ozsahin","CONTACT","+90 536 925 67 21","yasemin.ozsahin@iuc.edu.tr",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Kerem Erkalp","+90 532 787 95 00","keremerkalp@hotmail.com",[26],{"facility":17,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":10,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"RECRUITING","Istanbul","Outside of the US","34000","Turkey (Türkiye)",{"type":33,"coordinates":34},"Point",[35,36],28.94966,41.01384,{"lat":36,"lon":35},[39,40,41,44,46,48],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},{"name":42,"role":43,"phone":10,"phoneExt":10,"email":10},"Gozde Altun","SUB_INVESTIGATOR",{"name":45,"role":43,"phone":10,"phoneExt":10,"email":10},"Ayla Esin",{"name":47,"role":43,"phone":10,"phoneExt":10,"email":10},"Ziya Salihoglu",{"name":49,"role":43,"phone":10,"phoneExt":10,"email":10},"Ali Murat Mert",{"type":51,"investigatorFullName":17,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","specialist","100622650","propofol-infusion-and-ponv-in-cardiac-surgery-100622650",false,"NCT07386379","Propofol Infusion and PONV in Cardiac Surgery","The Effect of Propofol Infusion on Postoperative Nausea and Vomiting in Cardiac Surgery: A Prospective Observational Cohort Study","nausea vomitng","Inclusion Criteria\n\nAge ≥ 18 years\n\nASA physical status III\n\nElective coronary artery bypass grafting (CABG)\n\nSurgery performed at Istanbul University-Cerrahpaşa, Cardiology Institute between November 2025 and March 2026\n\nExclusion Criteria\n\nGastrointestinal or central nervous system disorders within the past 3 months\n\nCochlear disorders associated with nausea and vomiting\n\nChronic opioid use\n\nAdvanced hepatic or renal disease\n\nAlcohol or substance abuse\n\nLeft ventricular ejection fraction \\\u003C 40%\n\nInability to be weaned from mechanical ventilation within 12 hours postoperatively\n\nPostoperative morphine administration in the intensive care unit\n\nCombined cardiac procedures (e.g., valve surgery)\n\nOff-pump surgery\n\nEmergency surgery\n\nReoperation due to bleeding or other complications\n\nRefusal to participate","ALL","18 Years",{"count":64,"type":65},60,"ESTIMATED","1 Day","OBSERVATIONAL","The aim of this observational cohort study is to evaluate the effect of high-dose versus low-dose propofol infusion on the incidence of postoperative nausea and vomiting (PONV) in patients undergoing coronary artery bypass grafting (CABG). The study also seeks to assess the predictive performance of the Apfel and Koivuranta risk scores for PONV in the cardiac surgery population.\n\nThe primary objective of this study is to determine the impact of routinely administered high-dose propofol on the incidence and severity of PONV in CABG patients.\n\nThe secondary objective is to evaluate the need for antiemetic therapy during the intensive care unit stay.\n\nThe investigators will compare patients receiving high-dose propofol with those receiving low-dose propofol to determine whether the antiemetic effect of propofol is dose-dependent.\n\nParticipants will be asked to:\n\nAllow PONV assessments to be performed during the first 24 hours postoperatively,\n\nProvide permission for the collection of clinical data (including demographic characteristics, risk scores, opioid consumption, etc.) for research purposes.",[70,71],"Postoperative Nausea and Vomiting","Cardiovascular Surgical Procedures",[70,73,74,71],"Propofol","Cardiac Surgical Procedures","2026-02-03",{"date":77,"type":78},"2026-02-04","ACTUAL",{"date":80,"type":78},"2025-11-01",{"date":82,"type":65},"2026-04-30",{"name":5,"class":6},1]