[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590804":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":36,"collaborators":38,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":25,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":70,"whyStopped":25,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":25},{"fullName":5,"class":6},"Kocaeli Sağlık ve Teknoloji Üniversitesi","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Control","ACTIVE_COMPARATOR","Age- and sex-matched postmenopausal women without knee pathology. Participants will perform the same passive and active joint position sense tests as the gonarthrosis group, before and after a control fatigue protocol using the Biodex system.",[13],"Diagnostic Test: Fatigue Protocol + Joint Position Sense Testing",{"label":15,"type":16,"description":17,"interventionNames":18},"Gonarthrosis Group","EXPERIMENTAL","Postmenopausal women aged 50-65 with Kellgren-Lawrence Grade 2-3 knee osteoarthritis.\n\nParticipants will undergo an isokinetic fatigue protocol at 180°\u002Fs using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","Fatigue Protocol + Joint Position Sense Testing","Groups will undergo an isokinetic fatigue protocol at 180°\u002Fs using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.",[15,9],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"hatice sena cinarli, assistant professor","CONTACT","+905436093619","haticesena.cinarli@kocaelisaglik.edu.tr",{"name":33,"role":29,"phone":34,"phoneExt":25,"email":35},"Ozan Uçar, Physical Therapist","+905387497609","oznucr@hotmail.com",{"type":37,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[39],{"name":40,"class":6},"Inonu University","100590804","proprioceptive-fatigue-adaptation-in-osteoarthritis-100590804",false,"NCT06972186","Proprioceptive Fatigue Adaptation in Osteoarthritis","Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis","PROFA-OA","Inclusion Criteria:\n\n* Female, aged 50-65\n* Postmenopausal\n* Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group\n* No lower extremity surgery in the last 6 months\n* No neuromuscular or orthopedic condition affecting the lower extremities\n\nExclusion Criteria:\n\n* Severe balance disorders or vestibular disease\n* Bilateral knee prosthesis or severe osteoporosis\n* Lower extremity musculoskeletal injury in the last 6 months",true,"FEMALE","45 Years","65 Years",{"count":54,"type":55},20,"ESTIMATED","INTERVENTIONAL",[58],"NA","This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.",[61,62,63,64],"Osteoarthritis of Knee","Proprioception","Isokinetic Test","Gonarthritis",[66,67,68,69],"osteoarthritis of knee","propripception","isokinetic test","gonarthritis","NOT_YET_RECRUITING","2025-05-06",{"date":73,"type":74},"2025-05-14","ACTUAL",{"date":76,"type":55},"2025-06-01",{"date":78,"type":55},"2025-12-01",{"name":5,"class":6}]