[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548602":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":12,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":12,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":12,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":12,"overallStatus":38,"whyStopped":12,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Shanghai Jiao Tong University School of Medicine","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Traditional Haplo identicle HCT","NO_INTERVENTION","Beijing haploidenticla HCT is the routinely traditional way used for haploidentical HCT",null,{"label":14,"type":15,"description":16,"interventionNames":17},"TCRαβ Depleted haploidentical HCT","EXPERIMENTAL","TCRαβ Depleted haploidentical HCT is experimental used to decrease GVHD and obtain better qulity of life for children with haploidentical HCT.",[18],"Procedure: TCRαβ Depleted haploidentical HCT",[20],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":12},"PROCEDURE","Use the CliniMACS TCRα\u002Fβ deplete from the mobilized peripheral blood stem cells of haploidentical donor in children",[14],[25],{"name":26,"affiliation":27,"role":28},"Jing Chen, PhD","Shanghai Children's Medical Center","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","38626161","82073","chenjing@scmc.com.cn",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":12,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University","RECRUITING","Shanghai","Shanghai Municipality","China","CN",{"type":44,"coordinates":45},"Point",[46,47],121.45806,31.22222,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":32,"phoneExt":33,"email":34},"J Chen, PhD",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Sijia Gu","Principal investigator","100548602","prospective-clinical-trial-for-children-with-tcr-depleted-vs-traditional-haplo-identicle-hsct-100548602",false,"NCT06423131","Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT","TCRαβ+ Cell Deleted Versus Traditional Haploidentical Hematopoietic Stem Cell Transplantation ：A Single-center, Prospective, Non-randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Age 8 weeks to 18 years\n* Children who meet the indicators haploidentical hematopoietic cell transplantation\n* No HLA ≥ 9\u002F10 donor or not suitable for this type of donor due to illness\n* Informed consent must be signed (by the patient or legal representative)\n\nExclusion Criteria:\n\n* Liver function abnormalities with bilirubin \\>2 mg\u002FdL and elevation of transaminases higher than 400 U\u002FL\n* Chronic active viral hepatitis\n* Ejection fraction \\\u003C50%\n* Respiratory failure necessitating supplemental oxygen\n* Patients with a history of psychiatric illness or a condition which could interfere with their ability to understand the requirements of the study\n* Patients unwilling or unable to comply with the protocol or unable to give informed consent\n* Concurrent severe or uncontrolled infection","ALL","8 Weeks","18 Years",{"count":67,"type":68},110,"ESTIMATED","INTERVENTIONAL",[71],"NA","This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα\u002Fβ+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic stem cell transplantation in children.",[74,75,76,77],"Graft-Versus-Host Disease","Hematopoietic Stem Cell Transplantation","Child, Only","Haploidentical Hematopoietic Stem Cell Transplantation","2024-05-26",{"date":80,"type":81},"2024-05-29","ACTUAL",{"date":78,"type":81},{"date":84,"type":68},"2028-03-31",{"name":54,"class":6},1]