[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613397":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":91,"collaborators":10,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":104,"maxAge":10,"enrollmentInfo":105,"targetDuration":10,"studyType":108,"phases":10,"briefSummary":109,"conditions":110,"keywords":10,"overallStatus":111,"whyStopped":10,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Xiamen Hospital of Traditional Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MNOSD patient group",null,"The NMOSD patient cohort consisted of adults (≥18 years) who met the 2021 Chinese diagnostic criteria, were AQP4-IgG seropositive, and provided informed consent.",[13],"Other: Sex hormone assay",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy control group","Age- and sex-matched healthy controls (≥18 years) who provided informed consent",[13],[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Sex hormone assay","This study will explore and validate the characteristics of sex hormone levels in MNMOSD",[9],{"type":6,"name":20,"description":24,"armGroupLabels":25,"otherNames":10},"This study will explore the comparison of sex hormone levels between a healthy control group and MNMOSD",[15],[27],{"name":28,"affiliation":5,"role":29},"Shiyong Li","STUDY_CHAIR",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Wei Yiming","CONTACT","+8615652385796","982210496@qq.com",[37,55,65,71,81],{"facility":38,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The First Affiliated Hospital of Xiamen university","Xiamen","Fujian","361000","China","CN",{"type":45,"coordinates":46},"Point",[47,48],118.08187,24.47979,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":53,"phoneExt":10,"email":54},"Jianpeng Li","+86 13860192261","806469536@qq.com",{"facility":56,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"The Second Affiliated Hospital of Xiamen Medical College",{"type":45,"coordinates":58},[47,48],{"lat":48,"lon":47},[61],{"name":62,"role":33,"phone":63,"phoneExt":10,"email":64},"Ruiqiang Peng","+86 15880297185","hbprq@163.com",{"facility":5,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},{"type":45,"coordinates":67},[47,48],{"lat":48,"lon":47},[70],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},{"facility":72,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Zhongshan Hospital (Xiamen), Fudan University",{"type":45,"coordinates":74},[47,48],{"lat":48,"lon":47},[77],{"name":78,"role":33,"phone":79,"phoneExt":10,"email":80},"Guoqiang Fei","+86 13681973572","fei.guoqiang@zs-hospital.sh.cn",{"facility":82,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":83,"geoPoint":85,"contacts":86},"Zhongshan Hospital Xiamen University",{"type":45,"coordinates":84},[47,48],{"lat":48,"lon":47},[87],{"name":88,"role":33,"phone":89,"phoneExt":10,"email":90},"Xingyu Chen","+86 136 0090 4488","2005chenxingyu@163.com",{"type":92,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Li Shiyong","Xiamen Traditional Chinese Medicine Hospital","100613397","prospective-cohort-study-of-neuromyelitis-optica-spectrum-disorders-nmosd-100613397",false,"NCT07266051","Prospective Cohort Study of Neuromyelitis Optica Spectrum Disorders (NMOSD)","NMOSD","Inclusion Criteria Inclusion Criteria for the NMOSD Patient Group\n\n* Aged 18 years or older, regardless of sex\n* Fulfilled the diagnostic criteria for Neuromyelitis Optica Spectrum Disorders as defined by the 2021 Chinese guidelines for the diagnosis and management of NMOSD\n* Seropositive for AQP4-IgG\n* Provided informed consent by the participant or their legal guardian\n\nInclusion Criteria for the Healthy Control Group\n\n* Aged 18 years or older, regardless of sex\n* Gender- and age-matched healthy individuals\n* Provided informed consent by the participant or their legal guardian\n\nExclusion Criteria\n\n* Diagnosis of other serious systemic diseases (e.g., malignancy)\n* Presence of severe psychiatric disorders that would preclude compliance with study procedures and\u002For follow-up assessments\n* History of infectious pathologies of the central nervous system\n* Those with severe liver and kidney function impairment or dysfunction of other vital organs\n* Patients with other conditions that do not allow participation in clinical research\n* Patients allergic to gadolinium-DPTA\n* Patients with other conditions that do not allow participation in clinical research",true,"ALL","18 Years",{"count":106,"type":107},4000,"ESTIMATED","OBSERVATIONAL","This study aims to characterize sex hormone alterations and their potential clinical significance in NMOSD patients from Southern China through comprehensive hormonal profiling.",[100],"NOT_YET_RECRUITING","2025-12-11",{"date":114,"type":115},"2025-12-18","ACTUAL",{"date":117,"type":107},"2025-12",{"date":119,"type":107},"2030-12",{"name":5,"class":6},5]