[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632637":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":10,"responsibleParty":22,"collaborators":10,"id":24,"slug":25,"hasResults":26,"nctId":27,"briefTitle":28,"officialTitle":29,"acronym":10,"eligibilityCriteria":30,"healthyVolunteers":26,"sex":31,"minAge":32,"maxAge":33,"enrollmentInfo":34,"targetDuration":37,"studyType":38,"phases":10,"briefSummary":39,"conditions":40,"keywords":45,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":10},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"PPGL Resection Cohort",null,"Patients diagnosed with pheochromocytoma or paraganglioma who are scheduled for elective surgical resection. All participants will undergo the same study procedures: preoperative data collection, CGM monitoring, AI and human preoperative assessment, intraoperative application of the real-time warning tool, and postoperative follow-up. No intervention is applied; this is purely observational.",[13],{"name":14,"affiliation":5,"role":15},"LE SHEN, MD, PhD","STUDY_CHAIR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"YE MA, MD","CONTACT","+86 18801015226","maye_thu16@163.com",{"type":23,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100632637","prospective-cohort-study-of-pheochromocytomaparaganglioma-100632637",false,"NCT07516275","Prospective Cohort Study of Pheochromocytoma\u002FParaganglioma","Validation and Extension Study of the Predictive Model for Intraoperative Hemodynamic Instability in Pheochromocytoma\u002FParaganglioma Resection - a Single-center, Prospective, Observational Cohort Study","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Diagnosed with pheochromocytoma\u002Fparaganglioma by imaging and laboratory tests and scheduled for elective resection.\n* Planned intraoperative continuous invasive arterial pressure monitoring.\n* Willing and able to provide written informed consent.\n* Able to comply with preoperative CGM monitoring, AI agent assessment, and postoperative follow-up.\n\nExclusion Criteria:\n\n* Intraoperative hemodynamic data missing ≥20%.\n* Postoperative histopathology excludes PPGL diagnosis.\n* Cardiac paraganglioma or metastatic PPGL.\n* Severe cardiac disease (e.g., severe valvular disease, severe heart failure) that could independently cause intraoperative HDI.\n* Pregnancy or breastfeeding.\n* Mental illness, cognitive impairment, or communication barriers that prevent compliance with study procedures.\n* Refusal to undergo CGM monitoring or AI agent assessment.\n* Major illness (e.g., acute myocardial infarction, stroke, severe infection) within 3 months prior to surgery.\n* Severe hepatic or renal insufficiency (Child-Pugh class C, eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²).","ALL","18 Years","99 Years",{"count":35,"type":36},200,"ESTIMATED","6 Weeks","OBSERVATIONAL","The study will enroll patients scheduled for PPGL removal surgery at Peking Union Medical College Hospital. Before surgery, researchers will use a 6-variable model to predict the patient's risk of experiencing severe blood pressure swings during the operation. During surgery, a real-time early warning tool will be tested for its ability to accurately predict blood pressure changes 60 seconds in advance. The study will also explore the value of continuous glucose monitoring (CGM) in understanding blood pressure fluctuations and evaluate the performance of an artificial intelligence (AI) agent for preoperative anesthesia assessment, comparing its accuracy, consistency, and efficiency against that of human anesthesiologists.\n\nParticipation involves no changes to the patient's standard surgical or medical care. It includes collecting clinical data, wearing a CGM sensor from the day before to the day after surgery, and having the preoperative assessment performed by both the AI agent and anesthesiologists.",[41,42,43,44],"Pheochromocytoma","Paraganglioma","Hemodynamic Instability","Intraoperative Complications",[41,42,43,46,47,48,49],"Predictive Model","Artificial Intelligence","Continuous Glucose Monitoring","Prospective Cohort","NOT_YET_RECRUITING","2026-04-02",{"date":53,"type":54},"2026-04-07","ACTUAL",{"date":56,"type":36},"2026-04",{"date":58,"type":36},"2028-02",{"name":5,"class":6}]