[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642040":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Cardenal Herrera University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Villareal FC Group",null,"The target population includes active athletes, both male and female players, both in developmental stages and at the professional level, participating in sports with a high risk of ACL injury, such as soccer, basketball, handball, and volleyball.",[13],{"name":14,"affiliation":5,"role":15},"Javier Martínez Gramage, Professor","STUDY_CHAIR",[17,21],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","+34617024366","jmg@uchceu.es",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Flavia Ms Costantino, Student","+34634455845","flavia.costantino@alumnos.uchceu.es",[26],{"facility":27,"status":10,"city":28,"state":29,"zip":30,"country":29,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Villareal Football Club","Villarreal","Spain","12540","ES",{"type":33,"coordinates":34},"Point",[35,36],-7.21533,38.72572,{"lat":36,"lon":35},[39,41],{"name":40,"role":18,"phone":19,"phoneExt":10,"email":20},"Javier Mr Martínez Gramage, Professor",{"name":42,"role":18,"phone":23,"phoneExt":10,"email":24},"Flavia Ms Costantino, PHD Student",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","JAVIER MARTI NEZ-GRAMAGE","Professor","100642040","prospective-cohort-study-of-villarreal-cf-youth-players-100642040",false,"NCT07653633","Prospective Cohort Study of Villarreal CF Youth Players","A Single-season Prospective Observational Cohort Study of the Villarreal CF Male Youth Academy\"","VILLAREALFC","Inclusion Criteria:\n\n* Active federation license with Villarreal CF during the study period.\n* Regular participation in training sessions and official competitions.\n* Aged between 10 and 45 years (encompassing academy, youth development, and first-team categories).\n* For participants under 18 years of age: mandatory written informed consent from a parent or legal guardian.\n* For minor participants aged ≥12 years: written informed assent must be provided by the athlete in addition to parental consent.\n\nExclusion Criteria:\n\n* Previous bilateral anterior cruciate ligament (ACL) reconstruction.\n* Active severe musculoskeletal injury that prevents the execution of biomechanical or physiological testing.\n* Systemic disease or medical condition that limits sports participation or interferes with the study's biological\u002Fphysiological parameters.\n* Deregistration or transfer to another sports club during the prospective follow-up period. Refusal or inability to comply with the protocol's testing procedures or long-term follow-up requirements.","ALL","10 Years","45 Years",{"count":59,"type":60},200,"ESTIMATED","4 Years","OBSERVATIONAL","Anterior cruciate ligament (ACL) injuries represent a highly relevant issue in both grassroots and professional sports, with a particularly high incidence in young and female populations. The objective of this project is to develop and validate a multiscale predictive algorithm for ACL injury risk in athletes from Villarreal CF (aged 10-45), integrating biomechanical, physiological, genetic, and gut microbiome biomarkers.\n\nThe study, with a prospective and longitudinal design (4 years), will include a cohort of 200-250 players from the academy and first team. The following assessments will be conducted: biomechanical analysis of jumps using force platforms (instrumented LESS), physiological monitoring through resting heart rate and nocturnal heart rate variability (HRV), genotyping from saliva samples, and characterization of the gut microbiome 16 rRNA sequencing. The systematic recording of training, exposures, and injuries will follow OSTRC criteria and will be supervised by the club's medical team.\n\nThe expected outcome is a multivariate predictive model, validated in a professional sports setting, capable of identifying individual risk profiles and generating a personalized score to guide preventive interventions (exercise, strength training, nutritional or probiotic strategies). This approach aims to reduce the incidence of ACL injuries, optimize performance, and translate biomedical knowledge into clinical and sports practice.",[65,66],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament (ACL)",[68,69,70,71,72,73],"Anterior cruciate ligament","injuries","COL1A1","COL5A1","PIEZO1\u002F2","gut microbiome","NOT_YET_RECRUITING","2026-06-16",{"date":77,"type":78},"2026-06-17","ACTUAL",{"date":80,"type":60},"2026-07",{"date":82,"type":60},"2027-05",{"name":5,"class":6},1]