[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601512":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":34,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":10,"eligibilityCriteria":41,"healthyVolunteers":38,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":21,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},{"fullName":5,"class":6},"Zhujiang Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Exposed Group",null,"Participants were planned to receive 2 cycles of intravenous neoad- juvant Tislelizumab (200 mg) every 3 weeks,and Paclitaxel 135-175mg\u002Fm² ,Cisplatin 80-120mg\u002Fm² or Carboplatin 0.3-0.4g\u002Fm² through intravenous infusion each 3-week cycle for 2 cycles.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Xiaozhi LV","CONTACT","+86-020-62782092","lxzsurgeon@126.com",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":10,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Department of Stomatology, Zhujiang Hospital, Southern Medical University","RECRUITING","Guangzhou","Guangdong","China","CN",{"type":27,"coordinates":28},"Point",[29,30],113.25,23.11667,{"lat":30,"lon":29},[33],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"type":35,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100601512","prospective-cohort-study-on-oral-microbiome-changes-in-patients-with-locally-advanced-oral-squamous-cell-carcinoma-following-neoadjuvant-chemoimmunotherapy-100601512",false,"NCT07111455","Prospective Cohort Study on Oral Microbiome Changes in Patients With Locally Advanced Oral Squamous Cell Carcinoma Following Neoadjuvant Chemoimmunotherapy","Inclusion Criteria:\n\n1. Oral squamous cell carcinoma (OSCC) diagnosed as locally advanced (T3N0M0, T1-3N1M0, T4aN0-2M0, T1-4aN3M0, or T4bN0-3M0) according to AJCC staging criteria.\n2. Their age ranged from 18 to 80 years;regardless of gender.\n3. Absence of prior head and neck radiation therapy or chemotherapy.\n4. Adequate blood function: white blood cell count (WBC) \\>＝3.5×10\\^9\u002FL, platelet count (PLT) \\>＝75×10\\^9\u002FL：Hemoglobin concentration (HGB) \\>＝90g\u002FL.\n5. Adequate liver function： total bilirubin (TBIL) \\\u003C＝ the upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \\\u003C＝2.5 times the upper limit of normal.\n6. Adequate renal function：estimated glomerular filtration rate (eGFR) greater than 45 mL\u002Fmin per 1.73 m².\n7. The heart, brain, lung and other vital organs function and general condition can tolerate NACI.\n8. PS score \\\u003C＝2.\n9. Signed informed consent form and voluntarily agreeing to participate in this study.\n\nExclusion Criteria:\n\n1. Pregnancy or lactation (for female participants).\n2. Patients with a history of epilepsy or psychiatric disorders that were not well-controlled.\n3. Patients with severe allergic diathesis or suspected or confirmed alcohol or drug addiction.\n4. Patients who had taken antibiotics within 7 days before enrollment.","ALL","18 Years","80 Years",{"count":46,"type":47},32,"ESTIMATED","OBSERVATIONAL","Investigating the Relationship Between Oral Microbiome Alterations and Tumor Markers in Locally Advanced Oral Squamous Cell Carcinoma (LA-OSCC) After Neoadjuvant Chemoimmunotherapy: Implications for Therapeutic Efficacy, Chemoresistance, and Prognostic Assessment",[51],"Locally Advanced Oral Squamous Cell Carcinoma",[53,54],"Oral Microbiome","Neoadjuvant Chemoimmunotherapy","2025-09-21",{"date":57,"type":58},"2025-09-23","ACTUAL",{"date":60,"type":58},"2025-07-22",{"date":62,"type":47},"2027-07-30",{"name":5,"class":6},1]