[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642118":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":137,"collaborators":10,"id":140,"slug":141,"hasResults":142,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":142,"sex":148,"minAge":10,"maxAge":10,"enrollmentInfo":149,"targetDuration":10,"studyType":152,"phases":10,"briefSummary":153,"conditions":154,"keywords":158,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":173},{"fullName":5,"class":6},"First Affiliated Hospital of Guangxi Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Suspected Optic Neuritis Differential-Diagnosis Cohort",null,"Individuals with acute or subacute visual loss or optic nerve-related visual dysfunction in whom optic neuritis is included in the differential diagnosis at initial clinical assessment. Participants undergo routine clinical evaluation, and study data are collected using a structured protocol-defined case report form. No treatment is assigned by the study. The 2022 International Criteria for Optic Neuritis will be evaluated alone and with the antibody-stratified adjunct as diagnostic index-test approaches.",[13],{"name":14,"affiliation":5,"role":15},"Yi Du, MD, PhD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","+86 771 5356507","duyinapoleon@gmail.com",[22,41,52,60,70,82,95,108,123],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Guangxi Minzu Hospital","RECRUITING","Nanning","Guangxi","530001","China","CN",{"type":31,"coordinates":32},"Point",[33,34],108.31667,22.81667,{"lat":34,"lon":33},[37],{"name":38,"role":18,"phone":39,"phoneExt":10,"email":40},"Meifeng Luo","+86 771 3131152","luomf9853@qq.com",{"facility":42,"status":24,"city":25,"state":26,"zip":43,"country":28,"countryCode":29,"cosmosGeoPoint":44,"geoPoint":46,"contacts":47},"The Second Affiliated Hospital of Guangxi Medical University","530005",{"type":31,"coordinates":45},[33,34],{"lat":34,"lon":33},[48],{"name":49,"role":18,"phone":50,"phoneExt":10,"email":51},"Wenqiao Huang","+86 771 3277068","wqhuang8674@163.com",{"facility":53,"status":24,"city":25,"state":26,"zip":54,"country":28,"countryCode":29,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"The First Affiliated Hospital of Guangxi Medical University","530021",{"type":31,"coordinates":56},[33,34],{"lat":34,"lon":33},[59],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},{"facility":61,"status":24,"city":25,"state":26,"zip":62,"country":28,"countryCode":29,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"Guangxi Jingliang Eye Hospital","530022",{"type":31,"coordinates":64},[33,34],{"lat":34,"lon":33},[67],{"name":68,"role":18,"phone":69,"phoneExt":10,"email":10},"Mukun Zhao","+86 771 7980630",{"facility":71,"status":24,"city":25,"state":26,"zip":72,"country":28,"countryCode":29,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Wuming Hospital of Guangxi Medical University","530199",{"type":31,"coordinates":74},[33,34],{"lat":34,"lon":33},[77,80],{"name":78,"role":18,"phone":79,"phoneExt":10,"email":10},"Xiaoyuan Ma","+86 771 6226473",{"name":81,"role":18,"phone":10,"phoneExt":10,"email":10},"Yihua Huang",{"facility":83,"status":24,"city":84,"state":26,"zip":85,"country":28,"countryCode":29,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"The Second People's Hospital of Qinzhou","Qinzhou","535000",{"type":31,"coordinates":87},[88,89],108.65061,21.98247,{"lat":89,"lon":88},[92],{"name":93,"role":18,"phone":94,"phoneExt":10,"email":10},"Fangfang Zhang","+86 777 3682222",{"facility":96,"status":24,"city":97,"state":26,"zip":98,"country":28,"countryCode":29,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Wuzhou Gongren Hospital","Wuzhou","543099",{"type":31,"coordinates":100},[101,102],111.28848,23.48054,{"lat":102,"lon":101},[105],{"name":106,"role":18,"phone":107,"phoneExt":10,"email":10},"Jun Yang","+86 774 2036883",{"facility":109,"status":24,"city":110,"state":26,"zip":111,"country":28,"countryCode":29,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"The First People's Hospital of Yulin","Yulin","537099",{"type":31,"coordinates":113},[114,115],110.14686,22.6305,{"lat":115,"lon":114},[118,121],{"name":119,"role":18,"phone":120,"phoneExt":10,"email":10},"Na Li","+86 775 2683288",{"name":122,"role":18,"phone":10,"phoneExt":10,"email":10},"Qingjuan Zhao",{"facility":124,"status":24,"city":125,"state":126,"zip":127,"country":28,"countryCode":29,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Lixiang Eye Hospital of Soochow University","Suzhou","Jiangsu","215000",{"type":31,"coordinates":129},[130,131],120.59538,31.30408,{"lat":131,"lon":130},[134],{"name":135,"role":18,"phone":136,"phoneExt":10,"email":10},"Yinbin Tang","+86 512 69359692",{"type":15,"investigatorFullName":138,"investigatorTitle":139,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Yi Du","Chief Physician, Department of Ophthalmology","100642118","prospective-evaluation-of-the-2022-optic-neuritis-criteria-when-optic-neuritis-is-suspected-100642118",false,"NCT07623252","Prospective Evaluation of the 2022 Optic Neuritis Criteria When Optic Neuritis Is Suspected","A Multicenter Prospective Diagnostic Accuracy Study of the 2022 International Criteria for Optic Neuritis and an Antibody-Stratified Adjunct in Acute or Subacute Visual Loss When Optic Neuritis Is Suspected in China","GX-ICON","Inclusion Criteria:\n\n1. Individuals presenting with a new acute or subacute episode of visual loss or optic nerve-related visual dysfunction in one or both eyes, for whom optic neuritis is considered a reasonable differential diagnosis by the treating clinical team at the initial clinical assessment and before final diagnostic adjudication.\n2. Symptom onset of the current episode within 90 days before enrollment.\n\nExclusion Criteria:\n\n1\\. The participant has previously been enrolled in this study. Each participant may be enrolled only once.\n\nA history of optic neuritis or recurrent optic neuropathy before the current episode is not an exclusion criterion.","ALL",{"count":150,"type":151},500,"ESTIMATED","OBSERVATIONAL","Optic neuritis is an important cause of acute or subacute visual loss. In clinical practice, optic neuritis must often be distinguished from other optic neuropathies, retinal diseases, anterior-segment or ocular media disorders, non-organic visual loss, and other mimics. The 2022 International Criteria for Optic Neuritis were developed to standardize the diagnosis of optic neuritis, but their performance in Chinese clinical settings, where aquaporin-4 immunoglobulin G-positive and myelin oligodendrocyte glycoprotein immunoglobulin G-positive optic neuritis are relatively common, remains uncertain.\n\nThis multicenter prospective observational study is enrolling patients with acute or subacute visual loss in whom optic neuritis is included in the differential diagnosis. The study is designed to evaluate the diagnostic performance of the 2022 International Criteria for Optic Neuritis alone and with an antibody-stratified adjunct. The index classifications will be compared with an expert-adjudicated reference-standard diagnosis. No experimental treatment is assigned by the study. All diagnostic tests and treatments are determined by the treating clinicians according to routine clinical care. Study data are collected using a structured protocol-defined case report form.",[155,156,157],"Optic Neuritis","Optic Neuropathy","Visual Loss",[159,160,161,162,163],"2022 International Criteria for Optic Neuritis","Diagnostic accuracy","Antibody-stratified adjunct","Aquaporin-4 immunoglobulin G","Myelin oligodendrocyte glycoprotein immunoglobulin G","2026-06-11",{"date":166,"type":167},"2026-06-15","ACTUAL",{"date":169,"type":167},"2025-01-06",{"date":171,"type":151},"2028-01",{"name":5,"class":6},9]