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All staging is via the American Joint Committee on Cancer (AJCC)\u002FInternational Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria.\n* Patient tumor must have somatic activating sensitizing mutation in EGFR (e.g., but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Plasma, cytology, or tumor tissue can be utilized for standard of care mutation testing.\n* Prior chemotherapy and\u002For immunotherapy administered as primary treatment for NSCLC before EGFR mutation was identified is allowed ≤ 45 days of study registration to allow for return of sequencing information.\n* Prior treatment with osimertinib administered as primary treatment for NSCLC is allowed ≤ 30 days of study registration (prior treatment with any other EGFR TKI agent is not allowed).\n* Patient must not be participating in EA5182 or any other cancer treatment trial. Osimertinib or osimertinib + chemotherapy\u002Fimmunotherapy given as first-line treatment for this disease cannot be given as part of a clinical trial.\n* Patients that have received prior radiation therapy in any setting for this disease are eligible.\n* Adults age ≥ 18 years.","ALL","18 Years",{"count":1837,"type":1838},538,"ESTIMATED","3 Years","OBSERVATIONAL","The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor (EGFR)-mutant Non-Small Cell Lung Cancer (NSCLC) to better understand the safety and effectiveness of these standard of care regimens.",[1843,1844,1845,1846],"Non Small Cell Lung Cancer","Epidermal Growth Factor Receptor Gene Mutation","Stage III Lung Cancer","Stage IV Lung Cancer",[11,1848,1849,1850,1851],"Cisplatin","Carboplatin","Pemetrexed","EGFR Mutated","2026-03-26",{"date":1854,"type":1855},"2026-03-27","ACTUAL",{"date":1857,"type":1855},"2024-09-17",{"date":1859,"type":1838},"2029-08",{"name":5,"class":6},146]