[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637552":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":43,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adult NSICU Patients",null,"Adult patients age 18 years or older admitted to the NSICU at UT Southwestern Medical Center. Diagnostic groups include but are not limited to aneurysmal subarachnoid hemorrhage, traumatic brain injury, intracerebral hemorrhage, acute ischemic stroke, seizure-related presentations, postoperative neurosurgical patients, disorders of consciousness, and encephalopathy. aSAH patients represent the priority enrollment group. All participants have at least one monitoring modality acquired: B4C extensometry placed by study personnel, and\u002For research data recorded from existing standard-of-care SedLine, NIRS, TCD, or long-term monitoring EEG monitoring.",[13],{"name":14,"affiliation":5,"role":15},"Noah Jouett, DO, PhD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","2147862783","Noah.Jouett@UTSouthwestern.edu",[22],{"facility":23,"status":10,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"UT Southwestern Medical Center - Clements University Hospital NSICU","Dallas","Texas","75390","United States","US",{"type":30,"coordinates":31},"Point",[32,33],-96.80667,32.78306,{"lat":33,"lon":32},[36,37,38,41],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},{"name":14,"role":15,"phone":10,"phoneExt":10,"email":10},{"name":39,"role":40,"phone":10,"phoneExt":10,"email":10},"Ulrike Hoffmann, MD, PhD","SUB_INVESTIGATOR",{"name":42,"role":40,"phone":10,"phoneExt":10,"email":10},"DaiWai Olson, PhD, RN",{"type":15,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Noah Jouett","Principal Investigator, Department of Anesthesiology and Pain Management","100637552","prospective-observational-multimodal-neuromonitoring-in-adult-nsicu-patients-100637552",false,"NCT07577713","Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients","Prospective Observational Multimodal Neuromonitoring in Adult Neurosciences Intensive Care Unit Patients: Characterization of Noninvasive Cerebral Autoregulation Indices, Quantitative EEG, and Physiologic Correlates Across NSICU Diagnoses","Inclusion Criteria:\n\n* Age 18 years or older\n* Admitted to the NSICU at UT Southwestern Medical Center\n* Informed consent obtained from subject or legally authorized representative (as defined under Texas Health and Safety Code Section 166.039), or consent process underway per institutional policy\n* At least one study monitoring modality feasible (SedLine qEEG and\u002For Brain4Care extensometry); NIRS data collected where already in standard clinical use\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Prisoner status\n* Active declination of participation by subject or legally authorized representative\n* Absence of both subject and legally authorized representative consent when required\n* Clinical condition preventing safe placement of any study monitor (e.g., extensive facial or scalp injury, surgical dressings or hardware at all possible sensor sites, open wounds at sensor locations, severe uncontrolled agitation)\n* Anticipated clinical data capture insufficient for meaningful analysis\n* Urgent clinical priorities making research monitor placement inappropriate at time of approach\n* Inability to provide informed consent in English; study consent materials are available in English only","ALL","18 Years",{"count":56,"type":57},300,"ESTIMATED","OBSERVATIONAL","This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center. The study acquires multimodal neuromonitoring data - including SedLine quantitative EEG (qEEG) from standard-of-care monitoring, Brain4Care (B4C) noninvasive intracranial dynamics monitoring, and near-infrared spectroscopy (NIRS)-derived cerebral autoregulation (CA) indices where NIRS is already in clinical use - and links these data to bedside physiologic, medication, diagnostic, and clinical outcome variables during standard care. No alteration of clinical management occurs. The study prioritizes aneurysmal subarachnoid hemorrhage (aSAH) patients to characterize the natural history of noninvasive CA parameter evolution through the delayed cerebral ischemia (DCI) window (admission through Day 14) and provides preliminary data for subsequent interventional study design.",[61,62,63,64,65,66],"Subarachnoid Hemorrhage, Aneurysmal","Brain Injuries, Traumatic","Cerebral Hemorrhage","Ischemic Stroke","Delayed Emergence From Anesthesia","Encephalopathy",[68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84],"aneurysmal subarachnoid hemorrhage","delayed cerebral ischemia","cerebral autoregulation","CPPopt","MAPopt","Brain4Care","SedLine","quantitative EEG","near-infrared spectroscopy","COx","TOxA","transcranial Doppler","neurocritical care","NSICU","noninvasive intracranial monitoring","Moberg Clinical Platform","multimodal neuromonitoring","NOT_YET_RECRUITING","2026-05-04",{"date":88,"type":89},"2026-05-11","ACTUAL",{"date":91,"type":57},"2026-07",{"date":93,"type":57},"2029-09",{"name":5,"class":6},1]