[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592917":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":60,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":11,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":11,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":89,"whyStopped":11,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative Training Group","EXPERIMENTAL",null,[13],"Device: Virtual reality cognitive function training",{"label":15,"type":16,"description":11,"interventionNames":17},"Preoperative Control Group","SHAM_COMPARATOR",[18],"Device: Virtual scene intervention",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Virtual reality cognitive function training","Participants will receive VR-based cognitive training over 4-5 days prior to surgery, with three daily 30-minute sessions (8:00-10:00 AM, 12:00-2:00 PM, and 5:00-7:00 PM), ensuring a total preoperative training duration ≥6 hours.\n\nThe intervention utilizes an immersive VR environment that simulates real-world scenarios and tasks. Training modules target multiple cognitive domains, including memory, executive function, calculation, and abstract reasoning, designed as engaging, game-like activities with a gradual learning curve.\n\nEach participant's regimen is personalized based on baseline cognitive assessments or physician prescriptions, adhering to the \"6-hour rule\" for standardized efficacy evaluation. The system incorporates adaptive difficulty adjustment, dynamically modifying task complexity in response to real-time performance.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Virtual scene intervention","The control group will receive non-interactive VR exposure using identical equipment and session duration as the training group (3×30-minute daily sessions for 4-5 days, totaling ≥6 hours), with all interactive functions disabled to eliminate potential media-related biases (e.g., 2D\u002F3D cognitive load differences from tablet-based interventions) and ensure between-group differences stem solely from interactive training while maintaining blinding integrity through equivalent hardware deployment.",[15],[30],{"name":31,"affiliation":5,"role":32},"Zhengqian Li, Associate Chief Physician","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","+86 156 1190 8458","zhengqianli@hsc.pku.edu.cn",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Ziyuan Shen","+86 150 0220 8972","15002208972@163.com",[43,55],{"facility":44,"status":11,"city":45,"state":46,"zip":11,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":11},"Peking university first hospital","Beijing","Beijing Municipality","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},{"facility":56,"status":11,"city":45,"state":46,"zip":11,"country":47,"countryCode":48,"cosmosGeoPoint":57,"geoPoint":59,"contacts":11},"Peking university third hospital",{"type":50,"coordinates":58},[52,53],{"lat":53,"lon":52},{"type":32,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Li Zhengqian","Associate Chief Physician",[64],{"name":65,"class":6},"Peking University First Hospital","100592917","prospective-randomized-controlled-trial-of-vr-cognitive-training-in-reducing-postoperative-delirium-in-elderly-patients-with-cerebral-small-vessel-disease-undergoing-non-cardiac-surgery-100592917",false,"NCT06999668","Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac Surgery","Inclusion Criteria:\n\nAge ≥ 65 years; Preoperative MRI diagnosis of cerebral small vessel disease (CSVD); Scheduled to undergo non-cardiac, non-intracranial procedures under general anesthesia; Expected surgery duration \\> 2 hours; ASA physical status classification: I-III; No use of cognitive-enhancing medications within 3 months prior to surgery; Willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\nContraindications to cranial MRI (e.g., cardiac pacemaker, metallic implants, etc.); Patients experiencing subjective discomfort (dizziness, nausea, vomiting) during VR device adaptation; Severe visual or auditory impairment; Severe hepatic or renal dysfunction; Pre-existing neuropsychiatric disorders (schizophrenia, epilepsy, Parkinson's disease, delirium, etc.); Inability to complete preoperative neuropsychological assessments (dementia, deaf-mutism, communication disorders); History of cerebrovascular events (stroke, transient ischemic attack, etc.) within 3 months prior to surgery; Current use of sedatives\u002Fantidepressants or history of psychoactive substance abuse\u002Falcoholism.","ALL","65 Years",{"count":75,"type":76},416,"ESTIMATED","INTERVENTIONAL",[79],"NA","This clinical study investigates whether virtual reality (VR)-based cognitive training can help prevent postoperative delirium (POD) in elderly non-cardiac patients with pre-existing cerebral small vessel disease (CSVD). With the global aging population undergoing more surgical procedures, POD has emerged as a serious complication in surgical patients that can prolong hospital stays and increase the risk of developing Alzheimer's disease. The study utilizes an innovative VR system that combines eye-tracking cognitive assessment with interactive rehabilitation games to evaluate and train patients' cognitive function before non-cardiac and non-intracranial operations. Conducted at Peking University Third Hospital and First Hospital, this research specifically targets patients undergoing general surgery, orthopedic surgery and other non-intracranial\u002Fnon-cardiac procedures to determine if this technology-based intervention can effectively reduce POD incidence in this population while exploring its underlying mechanisms. The findings could lead to a practical solution for protecting cognitive health in elderly patients undergoing routine surgical procedures during recovery",[82,83],"Postoperative Delirium (POD)","Cerebral Small Vessel Diseases",[85,86,87,88],"postoperative delirium","cerebral small vascular disease","virtual reality","cognitive function","NOT_YET_RECRUITING","2025-05-22",{"date":92,"type":93},"2025-05-31","ACTUAL",{"date":92,"type":76},{"date":96,"type":76},"2027-12-31",{"name":5,"class":6},2]