[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635251":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":10,"responsibleParty":29,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":10,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":10,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":10},{"fullName":5,"class":6},"Gansu Provincial Maternal and Child Health Care Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"All eligible children aged 28 days to \u003C18 years with acute ischemic stroke (AIS) enrolled consecutiv",null,"All eligible children aged 28 days to \\\u003C18 years with acute ischemic stroke (AIS) enrolled consecutively from approximately 25-35 participating centers in China. Patients receive standard clinical management without treatment restrictions. Data collected include baseline demographics, clinical presentation, treatment strategies (medical therapy alone or endovascular treatment including stent retrieval, aspiration, balloon angioplasty, stenting, or intra-arterial thrombolysis), imaging parameters, safety outcomes, and functional outcomes assessed by pediatric modified Rankin Scale (ped-mRS) at 90 days and 6 months.",[13],"Other: Standard Clinical Management",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Standard Clinical Management","Participants receive routine clinical care per each center's standard practice. Treatment may include medical therapy (antiplatelet agents, anticoagulation) and\u002For endovascular treatment (stent retriever, aspiration thrombectomy, balloon angioplasty, stenting, or intra-arterial thrombolysis), as determined by the treating physician. No protocol-mandated intervention is applied.",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jian Liu President, Gansu Provincial Maternity and Child-Care Hospital, MD","CONTACT","+86 13609354197","Medecinliu@sina.com",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Rong Yin Chief, Division of Neurology, MD","+83 13919930466","yin_rong_@163.com",{"type":30,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100635251","prospective-registry-of-acute-ischemic-stroke-in-children-under-18-years-old-in-china-100635251",false,"NCT07550257","Prospective Registry of Acute Ischemic Stroke in Children Under 18 Years Old in China","Prospective Registry of Acute Ischemic Stroke in Children Under 18 Years Old in China (KIDS-AIS-REGISTRY)","Inclusion Criteria:\n\n* Age \\>28 days and \\\u003C18 years;\n* Presence of stroke-related symptoms (hemiparesis, facial palsy, aphasia, altered level of consciousness, seizure, headache) or atypical symptoms (sudden lethargy or irritability, crying, feeding difficulties, incontinence, sensory loss, ataxia, vertigo, nausea and\u002For vomiting, neck pain, fever);\n* First-ever stroke and onset within ≤7 days prior to admission;\n* Acute ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI);\n* Legal guardian provides signed informed consent;\n* For children aged ≥8 years to \\\u003C18 years who are conscious and without comprehension impairment, assent obtained from the child;\n\nExclusion Criteria:\n\n* Lack of imaging examination or stroke diagnosed without imaging\n* History of hypoxic-ischemic encephalopathy\n* Ischemic stroke caused by cerebral venous system\n* Concurrent presence of indistinguishable ischemic and hemorrhagic stroke","ALL","28 Days","18 Years",{"count":42,"type":43},1000,"ESTIMATED","OBSERVATIONAL","This observational study aims to investigate the real-world effectiveness and safety of different treatment strategies for acute ischemic stroke (AIS) in Chinese children under 18 years of age.\n\nIts primary research question is: In real-world clinical practice, does endovascular therapy (e.g., stent retriever thrombectomy, aspiration thrombectomy) improve 90-day functional outcomes in pediatric AIS patients with acute anterior or posterior circulation large vessel occlusion? Children under 18 years of age receiving routine AIS diagnosis and treatment at approximately 25-35 study centers across China will undergo neurological function assessments, imaging examinations, and evaluations of growth, development, and psychosocial status at baseline, 24 hours post-procedure, 7 days post-procedure or at hospital discharge, and at 90 days and 6 months post-onset. Adverse events will also be documented.",[47],"Acute Ischemic Stroke (AIS), Pediatric Stroke","NOT_YET_RECRUITING","2026-04-19",{"date":51,"type":52},"2026-04-24","ACTUAL",{"date":54,"type":43},"2026-06-01",{"date":56,"type":43},"2029-12-31",{"name":5,"class":6}]