[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548187":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":32,"responsibleParty":50,"collaborators":30,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":30,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":30,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":30,"overallStatus":35,"whyStopped":30,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Women's Hospital School Of Medicine Zhejiang University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"membrane-inhibiting formula combined with oral progestins","EXPERIMENTAL","Megestrol acetate(160mg\u002Fday) and membrane-inhibiting formula, 24weeks",[13],"Drug: Megestrol Acetate 40 MG",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Megestrol Acetate 40 MG","160mg\u002Fone time\u002Fday",[9],[21],"membrane-inhibiting formula",[23],{"name":24,"affiliation":5,"role":25},"Yang Li, Doctor","PRINCIPAL_INVESTIGATOR",[27],{"name":24,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","0086-18268165386",null,"5516015@zju.edu.cn",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Women's Hospital School of Medicine Zhejiang University","RECRUITING","Hangzhou","Zhejiang","321006","China","CN",{"type":42,"coordinates":43},"Point",[44,45],120.16142,30.29365,{"lat":45,"lon":44},[48],{"name":49,"role":28,"phone":29,"phoneExt":30,"email":31},"Li Yang",{"type":51,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100548187","prospective-study-for-endometrial-carcinoma-and-hyperplasia-in-childbearing-age-women-100548187",false,"NCT06417736","Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women","Prospective Clinical Study of Fertility-sparing Treatment With a Membrane-inhibiting Formula Combined With Oral Progestins for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women","Inclusion Criteria:\n\n* 1.18-45 years old with a strong desire to preserve fertility; 2. pathologically diagnosed with primary grade1 or grade2 endometrioid endometrial carcinoma and hyperplasia 3.no signs of suspicious myometrial invasion by enhanced magnetic resonance imaging (MRI) 4. no signs of suspicious extrauterine metastasis by enhanced computed tomography and CT scan of the Lungs\n\nExclusion Criteria:\n\n* 1.have contraindication for pregnancy. 2.no fertility requiremen 3.have myometrial invasion or extrauterine metastasis 4.pathologically diagnosed with primary grade3 endometrioid endometrial carcinoma or non-endometrioid endometrial carcinoma 5.Any disease or symptom that may affect the implementation of the study or the interpretation of the results","FEMALE","18 Years","45 Years",{"count":63,"type":64},75,"ESTIMATED","INTERVENTIONAL",[67],"NA","The goal of this clinical trial is to evaluate the effect and adverse side effects of membrane-inhibiting formula plus oral progestins as fertility-preserving treatment in patients with early-stage endometrial cancer and endometrial hyperplasia research questions：When taken with oral progestins, does the drug membrane-inhibiting formula shorten the time required for complete endometrial remission? What medical problems do participants have when taking drug membrane-inhibiting formula plus oral progestins? Efficacy, side effects, recurrence, pregnancy, and time to obtain pregnancy in different molecular classifications of POLE-mutated, mismatch repair-deficient(MMRd), p53 wild type(p53wt), and p53-abnormal(p53abn).\n\nParticipants will: Take drug membrane-inhibiting formula plus oral progestins every day Visit the clinic once every 3 months for checkups, tests, and hysteroscopy Keep a diary of examination results and pathology",[70,71],"Endometrial Cancer Stage I","Endometrial Hyperplasia","2024-05-12",{"date":74,"type":75},"2024-05-16","ACTUAL",{"date":77,"type":75},"2023-12-01",{"date":79,"type":64},"2026-12-31",{"name":5,"class":6},1]