[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602165":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":96,"collaborators":23,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":100,"sex":106,"minAge":107,"maxAge":23,"enrollmentInfo":108,"targetDuration":23,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":40,"whyStopped":23,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","OTHER","Group of patients with MASLD and\u002For ALD at cirrhosis stage, without HCC",[13],"Other: Blood, urine and stool biocollection",{"label":15,"type":10,"description":16,"interventionNames":17},"Case group","Group of patients with MASLD and\u002For ALD at cirrhosis stage and complicated by HCC",[13],[19],{"type":10,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Blood, urine and stool biocollection","Collection of blood, urine and stool sampling in order to build up a biocollection",[15,9],null,[25],{"name":26,"affiliation":5,"role":27},"Jérôme BOURSIER, Professor","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","+33 (0)2 41 35 64 28","JeBoursier@chu-angers.fr",{"name":34,"role":30,"phone":35,"phoneExt":23,"email":36},"Matthieu LE LAY, Master","+33 (0)2 41 35 58 91","matthieu.lelay@chu-angers.fr",[38,57,72,82],{"facility":39,"status":40,"city":41,"state":23,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Angers University Hospital","RECRUITING","Angers","49000","France","FR",{"type":46,"coordinates":47},"Point",[48,49],-0.55202,47.47156,{"lat":49,"lon":48},[52,53,56],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},{"name":54,"role":30,"phone":31,"phoneExt":23,"email":55},"Jeanne FICHEZ","Jeanne.Fichez@chu-angers.fr",{"name":26,"role":27,"phone":23,"phoneExt":23,"email":23},{"facility":58,"status":59,"city":60,"state":23,"zip":61,"country":43,"countryCode":44,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Centre Eugène Marquis (Oncology center)","NOT_YET_RECRUITING","Rennes","35000",{"type":46,"coordinates":63},[64,65],-1.67431,48.11109,{"lat":65,"lon":64},[68],{"name":69,"role":30,"phone":70,"phoneExt":23,"email":71},"Julien EDELINE","+33 (0)2 99 25 31 96","j.edeline@rennes.unicancer.fr",{"facility":73,"status":59,"city":60,"state":23,"zip":61,"country":43,"countryCode":44,"cosmosGeoPoint":74,"geoPoint":76,"contacts":77},"Rennes University Hospital, Hepatogastroenteroly Department",{"type":46,"coordinates":75},[64,65],{"lat":65,"lon":64},[78],{"name":79,"role":30,"phone":80,"phoneExt":23,"email":81},"Edouard BARDOU-JACQUET","+33 (0)2 99 28 42 98","edouard.bardou.jacquet@chu-rennes.fr",{"facility":83,"status":59,"city":84,"state":23,"zip":85,"country":43,"countryCode":44,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Tours University Hospital, HepatoGastroenterology Department","Tours","37170",{"type":46,"coordinates":87},[88,89],0.70398,47.39484,{"lat":89,"lon":88},[92],{"name":93,"role":30,"phone":94,"phoneExt":23,"email":95},"Laure ELKRIEF","+33 (0)2 47 47 59 65","L.ELKRIEF@chu-tours.fr",{"type":97,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100602165","prospexpo--study-of-the-associations-between-hepatocellular-carcinoma-and-chemical-and-psychosocial-environmental-exposome-100602165",false,"NCT07119957","ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome","ProspEXPO : PROSPective Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome","ProspEXPO","Inclusion Criteria:\n\n* Presence of metabolic and\u002For alcoholic steatotic liver disease, as defined by the new nomenclature (MASLD, ALD, or mixed MetALD)\n* Liver biopsy performed (less than 2 months ago) or planned as part of treatment for diagnosis of cirrhosis (\"Control\" group without HCC) or diagnosis of HCC on cirrhosis (\"Case\" group)\n* Patient affiliated to or benefiting from a social security scheme\n* Patient having signed an informed consent to participate in the study (bio-collection)\n\nExclusion Criteria:\n\n* Causes of chronic liver disease other than MASLD, ALD, or MetALD\n* Decompensation of cirrhosis in the two years prior to inclusion (ascites, hepatic encephalopathy, gastrointestinal variceal hemorrhage, liver failure, hepatorenal syndrome)\n* For the \"Control\" group: history of hepatocellular carcinoma\n* Pregnant, breast-feeding or parturient women\n* Persons deprived of liberty by judicial or administrative decision","ALL","18 Years",{"count":109,"type":110},300,"ESTIMATED","INTERVENTIONAL",[113],"NA","The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition, physical activity, socio-demographic conditions, tobacco, alcohol, pollutants) on the occurrence of the main type of liver cancer (called HCC).\n\nIndeed, in the vast majority of cases, HCC develops within cirrhosis, and the factors that precipitate the progression of cirrhotic patients to HCC remain largely unknown.",[116,117],"Cirrhoses, Liver","Carcinoma Liver",[119,120,121],"Liver Cirrhosis","HepatoCellular Carcinoma (HCC)","Exposome","2026-06-09",{"date":124,"type":125},"2026-06-10","ACTUAL",{"date":127,"type":125},"2025-12-17",{"date":129,"type":110},"2029-03",{"name":5,"class":6},4]