[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558152":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":79,"collaborators":81,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":43,"eligibilityCriteria":89,"healthyVolunteers":86,"sex":90,"minAge":91,"maxAge":43,"enrollmentInfo":92,"targetDuration":43,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":43,"overallStatus":52,"whyStopped":43,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Royal North Shore Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Adaptive radiotherapy +\u002F- margin reduction","ACTIVE_COMPARATOR","Phase 1 and 2: Treating Radiation Therapists (RTs) on the treatment machine will review the treatment target and organs at risk contours that are automatically generated on the plan of the day. They will modify these safely, as required, and then also approve the computer generated re-plan of the day, within the bounds of departmental protocols and decision guides (RT led).\n\nPhase 2 only: Margin reduction facilitated by adaptive radiotherapy.",[13],"Radiation: Adaptive radiotherapy +\u002F- Margin Reduction",{"label":15,"type":10,"description":16,"interventionNames":17},"Standard radiotherapy","Patients will receive standard image guided radiotherapy",[18],"Radiation: Image guided radiotherapy",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"RADIATION","Adaptive radiotherapy +\u002F- Margin Reduction","Radiotherapy using adaptive technology to recontour and replan daily as required. Reductions in the PTV margin will also be introduced in the second phase of this study.",[9],[26],"ART",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Image guided radiotherapy","Standard radiation treatment used in the department of radiation oncology for prostate cancer",[15],[32],"IGRT",[34],{"name":35,"affiliation":36,"role":37},"Andrew Prof Kneebone, MBBS","Northern Sydney Local Health District","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Nada Cheikh-Ali","CONTACT","+61294631345",null,"nada.cheikhali@health.nsw.gov.au",{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},"Heidi Tsang","+61294631340","heidi.tsang@health.nsw.gov.au",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Northern Sydney Cancer Centre, Royal North Shore Hospital","RECRUITING","St Leonards","New South Wales","2065","Australia","AU",{"type":59,"coordinates":60},"Point",[61,62],151.19836,-33.82344,{"lat":62,"lon":61},[65,69,70,73,75,77],{"name":66,"role":41,"phone":67,"phoneExt":43,"email":68},"Andrew Kneebone, MBBS","+61294631300","Andrew.Kneebone@health.nsw.gov.au",{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},{"name":71,"role":72,"phone":43,"phoneExt":43,"email":43},"Thomas Eade, MBBS","SUB_INVESTIGATOR",{"name":74,"role":72,"phone":43,"phoneExt":43,"email":43},"George Hruby, MBBS",{"name":76,"role":72,"phone":43,"phoneExt":43,"email":43},"Sarah Bergamin, MBBS",{"name":78,"role":72,"phone":43,"phoneExt":43,"email":43},"Joseph Chan, MBBS",{"type":80,"investigatorFullName":43,"investigatorTitle":43,"investigatorAffiliation":43,"oldNameTitle":43,"oldOrganization":43},"SPONSOR",[82],{"name":83,"class":6},"Northern Sydney and Central Coast Area Health Service","100558152","prostate-adaptive-radiation-therapy-100558152",false,"NCT06547398","Prostate Adaptive Radiation Therapy","Inclusion Criteria:\n\n1. \\- Age \\> 18\n2. Biopsy proven prostate malignancy\n3. Definitive treatment is radiotherapy to the prostate alone\n4. ECOG performance status 0-2\n5. Ability to understand and the willingness to sign an informed consent\n\nExclusion Criteria:\n\n1. Hip prosthesis\n2. Patient separation from prostate centre to skin edge \\> 24cm, measured on diagnostic scan-","MALE","18 Years",{"count":93,"type":94},130,"ESTIMATED","INTERVENTIONAL",[97],"NA","Prostate ART is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for prostate cancer patients.\n\nAdaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced.\n\nPhase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2.\n\nPart 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for prostate cancer patients.",[100],"Prostatic Neoplasms","2026-02-03",{"date":103,"type":104},"2026-02-05","ACTUAL",{"date":106,"type":104},"2025-10-01",{"date":108,"type":94},"2031-10-31",{"name":5,"class":6},1]