[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100368947":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":49,"responsibleParty":67,"collaborators":31,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":31,"enrollmentInfo":78,"targetDuration":31,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":31,"overallStatus":51,"whyStopped":31,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University Hospital Heidelberg","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"70.0\u002F 2.0 Gray (RBE)","ACTIVE_COMPARATOR","Normofractionated radiotherapy with photons (70.0\u002F 2.0 Gray)",[13],"Radiation: Normofractionated radiotherapy with photons",{"label":15,"type":16,"description":17,"interventionNames":18},"57.0\u002F 3.0 Gray (RBE)","EXPERIMENTAL","Hypofractionated radiotherapy with photons (57.0\u002F 3.0 Gray)",[19],"Radiation: Hypofractionated radiotherapy with photons",{"label":21,"type":16,"description":22,"interventionNames":23},"57.0\u002F 3.0 (RBE)","Hypofractionated radiotherapy with protons (57.0\u002F 3.0 Gray relative biological effectiveness \\[RBE\\]).",[24],"Radiation: Hypofractionated radiotherapy with protons",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"RADIATION","Hypofractionated radiotherapy with photons","hypofractionated radiotherapy with photons (total dose 57.0 Gray in 19 fractions)",[15],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Hypofractionated radiotherapy with protons","hypofractionated radiotherapy with protons (total dose 57.0 Gray relative biological effectiveness (RBE) in 19 fractions)",[21],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Normofractionated radiotherapy with photons","normofractionated radiotherapy with photons (total dose 70.0 Gray in 35 fractions)",[9],[41],{"name":42,"affiliation":5,"role":43},"Juergen Debus","PRINCIPAL_INVESTIGATOR",[45],{"name":42,"role":46,"phone":47,"phoneExt":31,"email":48},"CONTACT","06221 56 8201","juergen.debus@med.uni-heidelberg.de",[50],{"facility":5,"status":51,"city":52,"state":31,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Heidelberg","69120","Germany","DE",{"type":57,"coordinates":58},"Point",[59,60],8.69079,49.40768,{"lat":60,"lon":59},[63,64],{"name":42,"role":46,"phone":47,"phoneExt":31,"email":48},{"name":65,"role":46,"phone":47,"phoneExt":31,"email":66},"Adriane Hommertgen","adriane.hommertgen@med.uni-heidelberg.de",{"type":43,"investigatorFullName":42,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Principal Investigator","100368947","prostate-cancer-patients-treated-with-alternative-radiation-oncology-strategies-100368947",false,"NCT04083937","Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies","PAROS","Inclusion Criteria:\n\n* histology-proven prostate cancer with Gleason Score and PSA-value;\n* indication for prostate bed irradiation (adjuvant\u002F salvage) after prostatectomy;\n* Karnofsky-Index ≥ 70%\n* age ≥ 18 years\n\nExclusion Criteria:\n\n* androgen deprivation therapy\n* lymphatic spread\n* macroscopic tumor\u002F R2\n* stage IV (M1)\n* previous irradiation","MALE","18 Years",{"count":79,"type":80},897,"ESTIMATED","INTERVENTIONAL",[83],"NA","As the most common male carcinoma, prostate cancer is a major tumor entity in oncology. In addition to definitive radiotherapy, surgical procedure is considered to be an oncologically equivalent therapeutic alternative for non-metastatic malignancies in the primary setting. However, a subsequent radiotherapy of the prostate bed is often necessary, which takes place as an \"adjuvant\" treatment immediately after surgery or in the course of a repeated increase in PSA and usually extends over several weeks. For the primary situation (without previous surgery), several randomized phase III clinical trials have shown that it is possible to shorten radiotherapy by increasing the single dose (called hypofractionation). In the context of two prospective Phase II studies, which were carried out in Heidelberg, it has since been shown that hypofractionation with both photons and protons is safe and feasible even in the postoperative situation.\n\nThe current, prospective and randomized PAROS study is now intended to demonstrate a multicentric phase III study as an improvement in the quality of life caused by rectum toxicity (primary endpoint) by the use of protons. The oncological non-inferiority of hypofractionated radiotherapy after surgery is a secondary endpoint.",[86],"Prostate Cancer","2026-03-06",{"date":89,"type":90},"2026-03-09","ACTUAL",{"date":92,"type":90},"2018-09-12",{"date":94,"type":80},"2029-01",{"name":5,"class":6},1]