[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571677":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":76,"collaborators":80,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":11,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":11,"enrollmentInfo":94,"targetDuration":11,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":106,"overallStatus":109,"whyStopped":11,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ANP group","EXPERIMENTAL",null,[13],"Drug: Angong Niuhuang Pill (ANP)",{"label":15,"type":6,"description":16,"interventionNames":17},"Control","standard treatment",[18],"Other: Control (Standard treatment)",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Angong Niuhuang Pill (ANP)","Angong Niuhuang Pill (ANP) (3 g\u002Fpill, 1 pill\u002Fday for 5 days)",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Control (Standard treatment)","Blank control",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Hong Liu, MD","CONTACT","18801281613","dr.hongliu@foxmail.com",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"Yong-feng Shao, MD","02568303101","yfshaojph@sina.com",[40,61],{"facility":41,"status":11,"city":42,"state":43,"zip":11,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Beijing Anzhen Hospital, Capital Medical University","Beijing","Beijing Municipality","China","CN",{"type":47,"coordinates":48},"Point",[49,50],116.39723,39.9075,{"lat":50,"lon":49},[53,56,58],{"name":54,"role":32,"phone":11,"phoneExt":11,"email":55},"Si-chong Qian, MD","drqsc1990a@163.com",{"name":57,"role":32,"phone":11,"phoneExt":11,"email":11},"Hong-jia Zhang, MD",{"name":59,"role":60,"phone":11,"phoneExt":11,"email":11},"Hai-yang Liu, MD","SUB_INVESTIGATOR",{"facility":62,"status":11,"city":63,"state":64,"zip":65,"country":44,"countryCode":45,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"The First Affiliated Hospital of Nanjing Medical University","Nanjing","Jiangsu","210029",{"type":47,"coordinates":67},[68,69],118.77778,32.06167,{"lat":69,"lon":68},[72,75],{"name":73,"role":32,"phone":33,"phoneExt":11,"email":74},"Wei Zhang, MD","zhangweijph@163.com",{"name":31,"role":60,"phone":11,"phoneExt":11,"email":11},{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Hong Liu","Principal Investigator of Department of Cardiovascular Surgery",[81,83],{"name":82,"class":6},"The First Affiliated Hospital with Nanjing Medical University",{"name":84,"class":6},"Beijing Anzhen Hospital","100571677","protective-effect-of-angong-niuhuang-against-negative-inflammatory-response-and-neurologic-dysfunction-after-cardiovascular-surgery-100571677",false,"NCT06723366","Protective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery","Protective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery (PANDA X)","Inclusion Criteria:\n\n* (1) an age \\> 18 years,\n* (2) underwent cardiovascular surgery,\n* (3) diagnosis of acute neurologic dysfunction, including but not limited acute cerebral infarction of the internal carotid artery system,\n* (4) a National Institutes of Health Stroke Scale (NIHSS) score ranging from 10 to 20,\n* (5) a time from symptom onset to randomization within 36 h,\n* (6) provision of informed consent.\n\nExclusion Criteria:\n\n* (1) not suitable for taking ANP after the dialectical process by a traditional Chinese medical doctor,\n* (2) received ANP within 1 month before stroke onset,\n* (3) liver failure,\n* (4) declined to participate in this study.","ALL","18 Years",{"count":95,"type":96},120,"ESTIMATED","INTERVENTIONAL",[99],"NA","Neurologic Dysfunction is one of the main factors contributing to poor outcomes in cardiac surgery patients, except for heart failure. Atherosclerosis of the aorta, a history of cerebral infarction, and cervical artery disease are common clinical risk factors for cerebral neurological dysfunction after cardiac surgery. Results of preclinical studies suggested that Angong Niuhuang Pills (ANPs), a traditional Chinese patent medicine, including realgar, cinnabaris, Bovis Calculus, artificial Moschus, and powdered buffalo horn extract, decreased infarct volume and cerebral edema, and presented anti- atherosclerosis and cardio-protective effects in clinical and preclinical studies. The PANDA X trial is designed as a pilot study to explore the safety and efficacy of ANP in patients with moderate-to-severe neurologic dysfunction after cardiovascular surgery.",[102,103,104,105],"Cardio-pulmonary Bypass","Cardiovascular Surgery","Cerebral Protection","Brain Injury",[107,108],"Inflammatory Response","cardiopulmonary bypass","NOT_YET_RECRUITING","2024-12-09",{"date":112,"type":113},"2024-12-12","ACTUAL",{"date":115,"type":96},"2025-01-01",{"date":117,"type":96},"2025-12-31",{"name":5,"class":6},2]