[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626632":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":40,"centralContacts":44,"locations":30,"responsibleParty":52,"collaborators":30,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":30,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":30,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":82,"whyStopped":30,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":30},{"fullName":5,"class":6},"Tel Aviv University","OTHER",[8,13,19],{"label":9,"type":6,"description":10,"interventionNames":11},"EVEN (Even Protein Distribution)","Participants consume an iso-caloric diet providing 1.6 g\u002Fkg\u002Fday protein, distributed evenly across three daily meals at approximately 08:00, 13:00, and 18:00, with each meal providing \\~one-third of daily protein. Participants follow an overnight protein fasting window of approximately 21:00-08:00.",[12],"Behavioral: Even Protein Distribution",{"label":14,"type":15,"description":16,"interventionNames":17},"FAST (Protein-Fasting Morning; Protein at Lunch + Dinner)","EXPERIMENTAL","Participants consume an iso-caloric diet providing 1.6 g\u002Fkg\u002Fday protein using a skewed distribution that creates a 16-hour protein-free window (21:00-13:00) by omitting protein at breakfast (breakfast contains carbohydrate and fat only). Daily protein intake is concentrated at lunch and dinner to achieve the total 1.6 g\u002Fkg\u002Fday target.",[18],"Behavioral: Skewed Protein Distribution (16-hour Protein-Fasting Window)",{"label":20,"type":15,"description":21,"interventionNames":22},"FAST-RESCUE (FAST + Leucine at Breakfast)","Identical dietary pattern to FAST: iso-caloric diet with 1.6 g\u002Fkg\u002Fday protein, protein-free breakfast, and protein concentrated at lunch and dinner, creating a 16-hour protein-free window (21:00-13:00).",[23],"Dietary Supplement: L-leucine supplementation",[25,31,36],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","L-leucine supplementation","Participants ingest 5 g free-form L-leucine at breakfast (\\~08:00) daily for 8 weeks. Leucine is provided as unflavored, pharmaceutical-grade instantized powder, reconstituted in water and consumed at the protein-free breakfast meal.",[20],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"BEHAVIORAL","Even Protein Distribution","Iso-caloric diet providing 1.6 g\u002Fkg\u002Fday protein evenly distributed across three daily meals for 8 weeks.",[9],{"type":32,"name":37,"description":38,"armGroupLabels":39,"otherNames":30},"Skewed Protein Distribution (16-hour Protein-Fasting Window)","Iso-caloric diet providing 1.6 g\u002Fkg\u002Fday protein with protein omitted at breakfast and concentrated at lunch and dinner, creating a 16-hour daily protein-free window for 8 weeks.",[14],[41],{"name":42,"affiliation":5,"role":43},"Yftach Gepner, PhD","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":30,"email":49},"Lien Bruck","CONTACT","0587487431","lien.brueck@gmail.com",{"name":46,"role":47,"phone":48,"phoneExt":30,"email":51},"lien.bruck@tauex.tau.ac.il",{"type":43,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Gepner Yftach","Principal Investigator - Professor","100626632","protein-distribution-and-leucine-supplementation-effects-on-body-composition-and-performance-in-tactical-athletes-100626632",false,"NCT07438158","Protein Distribution and Leucine Supplementation Effects on Body Composition and Performance in Tactical Athletes","The Effect of Protein Distribution and Leucine Supplementation on Body Composition, Physical Performance, and Myofibrillar Damage in Tactical Athletes: a Randomized Controlled Trial During 8 Weeks of Intensive Training","Inclusion Criteria:\n\n* Male participants aged 18-35 years\n* Enrolled in an active Ministry of Defense tactical training program\n* Physically active and medically cleared to participate in intensive training\n* Willing and able to comply with the dietary intervention and training protocol\n* Provide written informed consent prior to participation\n\nExclusion Criteria:\n\n* Musculoskeletal or neuromuscular injury or impairment limiting participation in exercise training\n* Cardiopulmonary disease (including recent myocardial infarction or unstable angina)\n* History of cancer, diabetes, thyroid disease, hypertension, or chronic renal failure\n* Cognitive impairment affecting ability to provide informed consent\n* Use of medications that may affect metabolism, muscle physiology, or exercise performance\n* Known allergy or intolerance to study dietary components or leucine supplementation\n* Non-compliance with study protocol requirements",true,"MALE","18 Years","35 Years",{"count":67,"type":68},69,"ESTIMATED","INTERVENTIONAL",[71],"NA","This randomized controlled trial will examine the effects of within-day protein distribution and leucine supplementation on body composition, physical performance, and biomarkers of muscle damage in tactical athletes during an 8-week intensive training program. Sixty-nine healthy male participants (18-35 years) enrolled in a Ministry of Defense training course will be randomly assigned to one of three iso-caloric dietary groups providing 1.6 g\u002Fkg\u002Fday of protein: (1) evenly distributed protein across three meals (EVEN), (2) a 16-hour daily protein fasting pattern with protein concentrated at lunch and dinner (FAST), or (3) the same fasting pattern with 5 g leucine supplementation at breakfast (FAST-RESCUE).\n\nPrimary outcomes include changes in lean body mass. Secondary outcomes include strength, anaerobic performance, and biochemical markers of muscle damage, including urinary titin N-terminal fragment (UTF). Assessments will be conducted at baseline, Week 5, and Week 8.",[74],"Muscle Damage",[76,77,78,79,80,81],"Tactical Athletes","Protein Distribution","Leucine Supplementation","Lean Body Mass","Muscle Protein Synthesis","Resistance Training","NOT_YET_RECRUITING","2026-02-26",{"date":85,"type":86},"2026-03-02","ACTUAL",{"date":88,"type":68},"2026-03",{"date":90,"type":68},"2028-12",{"name":5,"class":6}]