[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633656":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":11,"locations":26,"responsibleParty":214,"collaborators":216,"id":220,"slug":221,"hasResults":222,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":222,"sex":228,"minAge":229,"maxAge":11,"enrollmentInfo":230,"targetDuration":11,"studyType":233,"phases":234,"briefSummary":236,"conditions":237,"keywords":11,"overallStatus":240,"whyStopped":11,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":250},{"fullName":5,"class":6},"Ziekenhuis Oost-Limburg","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low protein enteral feeding formula","EXPERIMENTAL",null,[13],"Other: enteral nutrition",{"label":15,"type":16,"description":11,"interventionNames":17},"Standard protein enteral feeding formula","ACTIVE_COMPARATOR",[13],[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"enteral nutrition","0.6 g protein\u002Fkg per day during the first 10 days of enteral nutrition and thereafter 0.8 g protein\u002Fkg per day",[9],{"type":6,"name":20,"description":24,"armGroupLabels":25,"otherNames":11},"1.3 g protein\u002Fkg per day during the entire treatment duration",[15],[27,44,56,69,79,92,105,118,131,140,153,163,173,186,199],{"facility":28,"status":11,"city":29,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"UZ Antwerpen","Antwerp","Belgium","BE",{"type":33,"coordinates":34},"Point",[35,36],4.40026,51.22047,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":11,"email":43},"Petra Vertongen","CONTACT","+32 (0)3 821 44 04","Studies.INZO@uza.be",{"facility":5,"status":11,"city":45,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":46,"geoPoint":50,"contacts":51},"Genk",{"type":33,"coordinates":47},[48,49],5.50082,50.965,{"lat":49,"lon":48},[52],{"name":53,"role":41,"phone":54,"phoneExt":11,"email":55},"Ingrid Meex","+32 (0)89 32 52 07","ingrid.meex@zol.be",{"facility":57,"status":11,"city":58,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"AZ Maria Middelares","Ghent",{"type":33,"coordinates":60},[61,62],3.71667,51.05,{"lat":62,"lon":61},[65],{"name":66,"role":41,"phone":67,"phoneExt":11,"email":68},"Annelies Van Damme","+32 (0)9 246 17 02","Annelies.VanDamme@mijnziekenhuis.be",{"facility":70,"status":11,"city":58,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"UZ Gent",{"type":33,"coordinates":72},[61,62],{"lat":62,"lon":61},[75],{"name":76,"role":41,"phone":77,"phoneExt":11,"email":78},"Daisy Vermeiren","+32 (0)9 332 05 08","Daisy.vermeiren@uzgent.be",{"facility":80,"status":11,"city":81,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Jessa Ziekenhuis","Hasselt",{"type":33,"coordinates":83},[84,85],5.33781,50.93106,{"lat":85,"lon":84},[88],{"name":89,"role":41,"phone":90,"phoneExt":11,"email":91},"Laurien Geebelen","+32 (0)11 33 98 85","Laurien.geebelen@jesszh.be",{"facility":93,"status":11,"city":94,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"UZ Brussel","Jette",{"type":33,"coordinates":96},[97,98],4.33419,50.87309,{"lat":98,"lon":97},[101],{"name":102,"role":41,"phone":103,"phoneExt":11,"email":104},"Merel Stevens","+32 (0)2 476 30 96","Merel.stevens@uzbrussel.be",{"facility":106,"status":11,"city":107,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"AZ Groeninge","Kortrijk",{"type":33,"coordinates":109},[110,111],3.26487,50.82803,{"lat":111,"lon":110},[114],{"name":115,"role":41,"phone":116,"phoneExt":11,"email":117},"Sofie Lagast","+32 (0)56 63 30 97","Sofie.lagast@azgroeninge.be",{"facility":119,"status":11,"city":120,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"UZ Leuven","Leuven",{"type":33,"coordinates":122},[123,124],4.70093,50.87959,{"lat":124,"lon":123},[127],{"name":128,"role":41,"phone":129,"phoneExt":11,"email":130},"Liese Mebis","+32 (0)16 34 40 21","liese.mebis@uzleuven.be",{"facility":119,"status":11,"city":120,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":132,"geoPoint":134,"contacts":135},{"type":33,"coordinates":133},[123,124],{"lat":124,"lon":123},[136],{"name":137,"role":41,"phone":138,"phoneExt":11,"email":139},"Shannon Nicolai","+32 (0)16 34 09 11","Studies.ial@uzleuven.be",{"facility":141,"status":11,"city":142,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"CHC MontLégia","Liège",{"type":33,"coordinates":144},[145,146],5.56749,50.63373,{"lat":146,"lon":145},[149],{"name":150,"role":41,"phone":151,"phoneExt":11,"email":152},"Leonie Deugoué, MD","+32 (0)498 28 64 30","deugoue.leonie@gmail.com",{"facility":154,"status":11,"city":142,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":155,"geoPoint":157,"contacts":158},"CHR de la Citadelle",{"type":33,"coordinates":156},[145,146],{"lat":146,"lon":145},[159],{"name":160,"role":41,"phone":161,"phoneExt":11,"email":162},"Maxime Samalea Suarez","+32 (0)4 321 51 06","Maxime.SamaleaSuarez@citadelle.be",{"facility":164,"status":11,"city":142,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":165,"geoPoint":167,"contacts":168},"CHU Liège",{"type":33,"coordinates":166},[145,146],{"lat":146,"lon":145},[169],{"name":170,"role":41,"phone":171,"phoneExt":11,"email":172},"Gwaëlle Ducomble","+32 (0)4 323 27 08","Gwaelle.Ducomble@chuliege.be",{"facility":174,"status":11,"city":175,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Clinique St. Pierre","Ottignies-Louvain-la-Neuve",{"type":33,"coordinates":177},[178,179],4.55023,50.66714,{"lat":179,"lon":178},[182],{"name":183,"role":41,"phone":184,"phoneExt":11,"email":185},"Anne Thirifays","+32 (0)10 43 75 56","Anne.thirifays@cspo.be",{"facility":187,"status":11,"city":188,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"AZ Delta","Roeselare",{"type":33,"coordinates":190},[191,192],3.12269,50.94653,{"lat":192,"lon":191},[195],{"name":196,"role":41,"phone":197,"phoneExt":11,"email":198},"Daphne Decruyenaere","+32 (0)51 23 76 83","daphne.decruyenaere@azdelta.be",{"facility":200,"status":11,"city":201,"state":11,"zip":11,"country":202,"countryCode":203,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"MUMC+","Maastricht","Netherlands","NL",{"type":33,"coordinates":205},[206,207],5.68889,50.84833,{"lat":207,"lon":206},[210],{"name":211,"role":41,"phone":212,"phoneExt":11,"email":213},"Marcel van de Poll","+31 (0)6 508 669 17","marcel.vande.poll@mumc.nl",{"type":215,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[217],{"name":218,"class":219},"Federaal Kenniscentrum voor Gezondheidszorg, Belgium","UNKNOWN","100633656","protein-provision-in-critical-illness--2-100633656",false,"NCT07529522","PRotEin Provision in Critical IllneSs -2","The Impact of Low Versus Standard Enteral Protein Provision on Health-related Quality of Life Following Intensive Care Admission: a Randomised Controlled, Multicentre, Parallel Group Trial in Mechanically Ventilated, Critically Ill Patients","PRECISe-2","Inclusion Criteria:\n\n* Adult (≥ 18 years-old) patient\n* Admission to the ICU\n* Invasive, mechanical ventilation initiated within 72 hours following ICU admission, or mechanically ventilated upon arrival to the ICU\n* Expected ICU stay on mechanical ventilation of ≥ 3 days after randomisation\n\nExclusion Criteria:\n\n* Expected contra-indication for enteral nutrition for at least one week, at the discretion of the treating physician, such as a bowel discontinuity that cannot be solved within one week\n* Moribund (expected to die within 48 hours) or withholding of treatment (DNR code 3)\n* Previous inclusion in the PRECISe-2 trial\n* Transfer from another ICU with an ICU stay longer than 3 days","ALL","18 Years",{"count":231,"type":232},1026,"ESTIMATED","INTERVENTIONAL",[235],"NA","When patients survive a life-threatening condition in the intensive care unit (ICU), they often face a prolonged recovery process marked by persistent health issues that significantly reduce their quality of life. Muscle weakness is the most defining feature of this post-intensive care syndrome. This weakness, along with the associated decline in quality of life, presents major challenges for patients, their families, and the healthcare system, including the high costs of long-term care.\n\nUntil recently, it was believed that providing additional nutrition-particularly protein-during the early phase of a critical illness could help prevent muscle loss and promote recovery. However, the recent PRECISe study showed that administering a high amount of protein (target: 2 g\u002Fkg per day) via feeding tube actually worsened outcomes: patients who received high-protein nutrition during the acute phase reported a lower quality of life over the six months following ICU admission and were discharged from the hospital later.\n\nThese findings from the PRECISe study have renewed attention on the amount of protein administered to critically ill patients. Current European ICU nutrition guidelines (1.3 g\u002Fkg per day) recommend a higher protein intake than the daily recommended amount for healthy individuals (0.8 g\u002Fkg per day). However, in critically ill patients, protein metabolism may be impaired, potentially leading to the accumulation of toxic protein breakdown products and hindering recovery, ultimately resulting in a lower quality of life.\n\nReducing protein intake below the level recommended for healthy individuals during the acute phase of a life-threatening illness-while maintaining total energy intake (calories)-may be beneficial for long-term recovery and rehabilitation.\n\nThe PRECISe-2 study investigates whether patients who receive less protein (0.6-0.8 g\u002Fkg per day) but sufficient energy during the early phase of their critical illness feel better and experience a higher quality of life in the long term compared to those who receive the standard amount of protein (1.3 g\u002Fkg per day).",[238,239],"Critical Illness","Intensive Care (ICU)","NOT_YET_RECRUITING","2026-04-20",{"date":243,"type":244},"2026-04-23","ACTUAL",{"date":246,"type":232},"2026-05",{"date":248,"type":232},"2029-07",{"name":5,"class":6},15]