[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556734":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":28,"locations":37,"responsibleParty":56,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":85,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Universidad Autonoma de San Luis Potosí","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with neurodegenerative disease",null,"Patients diagnosed with either Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism or amyotrophic lateral sclerosis.",[13],"Diagnostic Test: Immunohistochemistry and immunofluorescence",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients with normal pressure hydrocephalus","Patients diagnosed with normal pressure hydrocephalus, because of their clinical presentation (acute or subacute gait abnormalities, memory loss or personality changes and urinary incontinence) with radiological confirmation of ventriculomegaly and normal cerebrospinal fluid opening pressure.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy control subjects","Person, men or women, above 45 years old, that don't have history of family or personal neurodegenerative disease.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","Immunohistochemistry and immunofluorescence","Skin biopsies will be analyzed using immunohistochemistry and immunofluorescence to detect the presence of aggregated a-synuclein, amyloid-b, p-TAU and TDP-43.",[19,9,15],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Ildefonso Rodríguez-Leyva, MD PhD","CONTACT","+52 444 834 2739","ilrole@yahoo.com.mx",{"name":35,"role":31,"phone":10,"phoneExt":10,"email":36},"Cristina Monzón Tapia, MD","a267473@alumnos.uaslp.mx",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hospital Central Dr. Ignacio Morones Prieto","RECRUITING","San Luis Potosí City","78290","Mexico","MX",{"type":46,"coordinates":47},"Point",[48,49],-100.97135,22.15234,{"lat":49,"lon":48},[52,53,54],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":35,"role":31,"phone":32,"phoneExt":10,"email":36},{"name":35,"role":55,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ildefonso Rodriguez-Leyva","Head of Neurology Service",[61],{"name":62,"class":6},"Hospital Central \"Dr. Ignacio Morones Prieto\"","100556734","proteinopathies-expression-in-skin-of-neurodegenerative-disorders-100556734",false,"NCT06528964","Proteinopathies Expression in Skin of Neurodegenerative Disorders","Expression of Proteinopathies in Skin Biopsies of Patients With Neurodegenerative Disorders","Inclusion Criteria for patients:\n\n* Patients 45 years and older\n* Men and women\n* Patients diagnosed with Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus\n* Patients that voluntarily accept to participate in the study and accept the consent form\n\nInclusion Criteria healthy control subjects:\n\n* People 45 years and older\n* Men and women\n* Subjects can be related to a patient but not by blood (for example spouse of a patient)\n* Subjects don't have direct family history of a neurodegenerative control\n* Subjects don't have any clinical findings suggesting dementia\n* Subjects voluntarily accept to participate in the study and accept the consent form\n\nExclusion Criteria:\n\n* Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia\n* Patients in which the diagnosis is not clear or hasn't been confirmed\n* Patients or controls that have a neuroinfection\n* Patients or controls that a diagnosed skin disease\n* Patients that have an \"atypical\" presentation of the disease\n* Patients or controls that have diagnosis of a coagulopathy",true,"ALL","45 Years",{"count":74,"type":75},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 \\[TDP43\\]) in skin biopsies of patients with a neurodegenerative disease like Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus. The main question it aims to answer is:\n\n* Is there a specific pattern of aggregation of proteinopathies in skin biopsies in each neurodegenerative disease in comparison to healthy control subjects?\n\nSkin biopsies will be analyzed using immunohistochemistry and immunofluorescence for detection of alpha-synuclein, amyloid-beta, phosphorylated tau and TAR DNA binding protein 43, and the aggregation patterns will be compared between patients with a neurodegenerative disease vs patient with normal pressure hydrocephalus vs healthy control subjects.",[79,80,81,82,83,84],"Alzheimer Disease","Frontotemporal Dementia","Parkinson Disease","Atypical Parkinsonism","Amyotrophic Lateral Sclerosis","Normal Pressure Hydrocephalus",[86,87,88,89],"Alpha Synuclein Pathology","Tauopathies","TDP-43 Proteinopathies","Beta-Amyloid","2024-12-13",{"date":92,"type":93},"2024-12-16","ACTUAL",{"date":95,"type":93},"2023-12-20",{"date":97,"type":75},"2026-11-01",{"name":5,"class":6},1]