[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586216":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":29,"responsibleParty":48,"collaborators":11,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":11,"maxAge":11,"enrollmentInfo":58,"targetDuration":11,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Proteomic-Based Prediction of Postnatal Kidney Function in Fetuses with Bilateral CAKUT","EXPERIMENTAL",null,[13],"Other: Amniotic Fluid Proteomic Analysis Using Capillary Electrophoresis-Mass Spectrometry (CE-MS)",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":11},"Amniotic Fluid Proteomic Analysis Using Capillary Electrophoresis-Mass Spectrometry (CE-MS)","This intervention consists of analyzing the amniotic fluid proteome using capillary electrophoresis coupled with mass spectrometry (CE-MS). The goal is to evaluate a predefined 98-peptide signature that predicts postnatal kidney function in fetuses with bilateral congenital anomalies of the kidney and urinary tract. Unlike standard prenatal assessments based on ultrasound and fetal biochemistry, this method provides a molecular-based prognostic tool to improve decision-making regarding pregnancy management and neonatal care",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Thomas SIMON","CONTACT","05 34 55 84 58","simon.t@chu-toulouse.fr",{"name":26,"role":22,"phone":27,"phoneExt":11,"email":28},"Nadège Algans","+33 05 61 77 72 04","algans.n@chu-toulouse.fr",[30],{"facility":31,"status":32,"city":33,"state":11,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Children Hospital","RECRUITING","Toulouse","31059","France","FR",{"type":38,"coordinates":39},"Point",[40,41],1.44367,43.60426,{"lat":41,"lon":40},[44,46],{"name":21,"role":22,"phone":45,"phoneExt":11,"email":24},"+33 05 34 55 84 58",{"name":21,"role":47,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"type":49,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100586216","proteomic-analysis-of-amniotic-fluid-to-predict-postnatal-renal-function-in-fetuses-with-renal-and-urinary-tract-malformations-100586216",false,"NCT06912490","Proteomic Analysis of Amniotic Fluid to Predict Postnatal Renal Function in Fetuses With Renal and Urinary Tract Malformations","PAPER FACE","Inclusion Criteria:\n\n* All fetuses with bilateral renal development anomalies with structural changes in the parenchyma, with or without associated urinary tract anomalies;\n* Signed informed consent of the mother\n* Non-opposition of the father.\n\nExclusion Criteria:\n\n* Unilateral abnormality of renal development\n* Any pregnancy for which amniocentesis may represent a risk for the fetus or the mother\n* Twin pregnancies\n* Pregnant woman protected by law (guardianship, curatorship)","FEMALE",{"count":59,"type":60},78,"ESTIMATED","INTERVENTIONAL",[63],"NA","The aim of this project is to validate a previously established amniotic fluid 98 peptide signature predictive of post-natal outcome in fetuses with congenital anomalies of the kidney and the urinary tract (CAKUT) in a \"real\" clinical context. It includes the feasibility of collecting, transporting and analyzing the amniotic fluid peptidome from clinical centers all over France and of providing the result in a clinically accepted time-frame. Therefore, this multicenter study will not only allow to determine the added value of such new prenatal test but also to ensure the feasibility of its introduction in the management of CAKUT pregnancies.",[66],"Kidney Diseases",[68,69,70,71,72,73],"Antenatal","fetal bilateral nephropathies","renal function","prognosis","proteomic analysis","renal ultrasound","2026-04-28",{"date":76,"type":77},"2026-05-04","ACTUAL",{"date":79,"type":77},"2025-07-18",{"date":81,"type":60},"2029-12-20",{"name":5,"class":6},1]