[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627728":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":49,"collaborators":53,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":26,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":90,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual Care HFNC Weaning","ACTIVE_COMPARATOR","During this phase, high-flow nasal cannula (HFNC) weaning and discontinuation are performed according to local standard practice without a mandated protocol. Decisions regarding reduction of flow and fraction of inspired oxygen (FiO₂), transition to conventional oxygen therapy, and re-escalation of support are made at the discretion of the treating clinical team.",[13],"Behavioral: Usual Care HFNC Weaning",{"label":15,"type":16,"description":17,"interventionNames":18},"Protocolized HFNC Weaning","EXPERIMENTAL","Participants receive a standardized HFNC weaning protocol consisting of structured, stepwise reduction of flow and FiO₂ with predefined criteria for discontinuation and criteria for treatment failure requiring re-escalation of respiratory support. The protocol is implemented at the hospital level during the intervention phase of the stepped-wedge design.",[19],"Behavioral: Protocolized HFNC Weaning Strategy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Protocolized HFNC Weaning Strategy","A standardized high-flow nasal cannula (HFNC) weaning protocol consisting of structured, stepwise reduction of flow and fraction of inspired oxygen (FiO₂) with predefined criteria for discontinuation and predefined criteria for treatment failure requiring re-escalation of respiratory support. The protocol is implemented at the hospital level during the intervention phase of the stepped-wedge cluster randomized design.",[15],null,{"type":22,"name":9,"description":28,"armGroupLabels":29,"otherNames":26},"High-flow nasal cannula (HFNC) weaning and discontinuation are performed according to local standard clinical practice without a mandated protocol. Decisions regarding reduction of flow and fraction of inspired oxygen (FiO₂), transition to conventional oxygen therapy, and escalation of respiratory support are made at the discretion of the treating clinical team.",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Jie Li, PhD","CONTACT","13125634643","Jie_Li@rush.edu",[37],{"facility":5,"status":26,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":26},"Chicago","Illinois","60612","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-87.65005,41.85003,{"lat":47,"lon":46},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Jie Li","Professor",[54,56,58,60,62,64],{"name":55,"class":6},"The First Affiliated Hospital of Xiamen University",{"name":57,"class":6},"First Hospital of China Medical University",{"name":59,"class":6},"Shanghai Zhongshan Hospital",{"name":61,"class":6},"Binzhou Medical University",{"name":63,"class":6},"First Affiliated Hospital of Chongqing Medical University",{"name":65,"class":6},"Changhai Hospital","100627728","protocolized-weaning-of-high-flow-nasal-cannula-in-adult-patients-100627728",false,"NCT07452406","Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients","Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients: A Stepped-Wedge Cluster Randomized Trial (PRO-WEAN HFNC)","PRO-WEAN HFNC","Inclusion Criteria:\n\n* Adult patients ≥ 18 years\n* Receiving HFNC for ≥12 hours\n* Receiving HFNC to treat acute hypoxemic respiratory failure, defined as requirement of FIO2 ≥ 0.5 to maintain SpO2 at 90-97% and Evidence of increased work of breathing at initiation (e.g., tachypnea with respiratory rate \\> 20-25\u002Fmin, or accessory muscle use), including:\n\n  * Patients using HFNC to avoid intubation\n  * Post-extubated patients who develop acute hypoxemic respiratory failure, regardless of respiratory support device prior to HFNC use.\n* The bedside clinical team determines that HFNC weaning is clinically appropriate\n* Demonstrates clinical stability, defined as:\n\n  * Respiratory rate ≤ 25 breaths per minute without use of accessory respiratory muscles\n  * SpO₂ \\> 90% on HFNC\n  * HFNC FiO₂ ≤ 0.80\n\nExclusion Criteria:\n\n* • Planned procedures requiring intubation\n\n  * Hypercapnia (PaCO2 ≥ 45 mmHg)\n  * Receiving extracorporeal membrane oxygenation (ECMO)\n  * Receiving continuous aerosol therapy via HFNC (e.g., inhaled nitric oxide \\[iNO\\], epoprostenol, or continuous albuterol)\n  * Receiving chronic home use of HFNC, CPAP, or noninvasive ventilation therapy to treat chronic respiratory failure\n  * Receiving HFNC as preventative post-extubation therapy, defined as HFNC use immediately after extubation for less than 48 hr in the absence of clinical signs of respiratory failure.","ALL","18 Years",{"count":77,"type":78},2000,"ESTIMATED","INTERVENTIONAL",[81],"NA","High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding how and when to reduce and stop this therapy once a patient improves. In many hospitals, these decisions vary from clinician to clinician.\n\nThis study will compare usual care with a standardized step-by-step plan for reducing HFNC support. Eight hospitals will participate and will switch from usual care to the standardized plan at different time points during the study.\n\nThe main goal is to determine whether the standardized weaning plan increases the number of patients who can successfully stop HFNC within 5 days. The study will also evaluate how long patients remain on HFNC, whether they need additional breathing support, and how long they stay in the hospital.\n\nThe results may help develop clearer guidance for safely and efficiently stopping HFNC therapy.",[84,85],"Acute Hypoxemic Respiratory Failure","High-Flow Nasal Cannula Therapy",[87,88,89],"High-flow nasal cannula","Acute hypoxemic respiratory failure","Weaning","NOT_YET_RECRUITING","2026-06-07",{"date":93,"type":94},"2026-06-10","ACTUAL",{"date":96,"type":78},"2026-09-01",{"date":98,"type":78},"2028-06-28",{"name":5,"class":6},1]