[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644921":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":45,"locations":52,"responsibleParty":68,"collaborators":72,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":35,"enrollmentInfo":90,"targetDuration":35,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":35,"overallStatus":55,"whyStopped":35,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Hospital Vall d'Hebron","OTHER",[8,15,19,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Prophylactic Mesh + Negative Pressure Wound Therapy","EXPERIMENTAL","Participants will undergo standard fascial closure reinforced with a prophylactic supra-aponeurotic non-absorbable mesh and postoperative negative pressure wound therapy using a PICO dressing for 7 days.",[13,14],"Procedure: Prophylactic Mesh Placement","Device: Negative Pressure Wound Therapy (NPWT)",{"label":16,"type":10,"description":17,"interventionNames":18},"Prophylactic Mesh without Negative Pressure Wound Therapy","Participants will undergo standard fascial closure reinforced with a prophylactic supra-aponeurotic non-absorbable mesh and standard postoperative wound dressing.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Conventional Closure + Negative Pressure Wound Therapy","ACTIVE_COMPARATOR","Participants will undergo standard fascial closure without mesh reinforcement and postoperative negative pressure wound therapy using a PICO dressing for 7 days.",[14,24],"Procedure: Standard Fascial Closure",{"label":26,"type":10,"description":27,"interventionNames":28},"Conventional Closure without Negative Pressure Wound Therapy","Participants will undergo standard fascial closure without mesh reinforcement and standard postoperative wound dressing.",[24],[30,36,41],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"PROCEDURE","Prophylactic Mesh Placement","Placement of a non-absorbable polypropylene or polyester mesh in a supra-aponeurotic position at the time of abdominal wall closure following cytoreductive surgery.",[9,16],null,{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":35},"DEVICE","Negative Pressure Wound Therapy (NPWT)","Application of a PICO negative pressure dressing after skin closure, maintained for 7 days postoperatively.",[20,9],{"type":31,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"Standard Fascial Closure","Continuous closure of the abdominal fascia using slowly absorbable monofilament suture (PDS 2-0), single-layer closure without peritoneal closure, maintaining a suture-to-wound length ratio greater than 4:1 and employing the small-bites technique.",[20,26],[46],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Jose Luis Sánchez Iglesias, MD PhD","CONTACT","+34 932746000","3217","jlsanig@yahoo.es",[53],{"facility":54,"status":55,"city":56,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Hospital Universitario Vall d'Hebron","RECRUITING","Barcelona","08035","Spain","ES",{"type":61,"coordinates":62},"Point",[63,64],2.15899,41.38879,{"lat":64,"lon":63},[67],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Jose Luis Sanchez","MD PhD",[73,75,78],{"name":74,"class":6},"Germans Trias i Pujol Hospital",{"name":76,"class":77},"Fundación Jimenez Diaz de Madrid","UNKNOWN",{"name":79,"class":6},"Hospital Universitario La Fe","100644921","prov-mesh-prophylactic-ovarian-cancer-mesh-100644921",false,"NCT07676370","PROV-MESH: Prophylactic Ovarian Cancer MESH","A Multicenter Randomized Clinical Trial Comparing Prophylactic Mesh Placement Versus Primary Closure, With or Without Negative Pressure Wound Therapy, in Patients Undergoing Primary or Interval Cytoreductive Surgery for Ovarian Cancer","PROV-MESH","Inclusion Criteria:\n\n* Female patients diagnosed with ovarian carcinoma.\n* Undergoing primary cytoreductive surgery, interval cytoreductive surgery, or delayed cytoreductive surgery after six cycles of chemotherapy.\n* Surgical procedure performed through a midline laparotomy.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Surgery for recurrent ovarian cancer (secondary, tertiary, or subsequent cytoreductions).\n* Minimally invasive surgical approach.\n* Planned secondary cytoreductive surgery during the 24-month follow-up period.\n* Inability or unwillingness to comply with follow-up requirements.","FEMALE","18 Years",{"count":91,"type":92},152,"ESTIMATED","INTERVENTIONAL",[95],"NA","Incisional hernia is a common complication after midline laparotomy and may significantly impact quality of life, morbidity, and healthcare costs. Patients undergoing cytoreductive surgery for ovarian cancer are considered at increased risk due to extensive surgical procedures, nutritional status, and exposure to systemic treatments.\n\nThis prospective randomized clinical trial aims to evaluate whether prophylactic mesh placement during abdominal wall closure reduces the incidence of incisional hernia compared with conventional fascial closure in women undergoing cytoreductive surgery for ovarian cancer through a midline laparotomy. To control for the potential effect of negative pressure wound therapy (NPWT) on surgical site infection, participants will also be randomized to receive NPWT or standard wound dressing, resulting in four treatment arms.",[98],"Ovarian Cancer","2026-06-24",{"date":101,"type":102},"2026-06-30","ACTUAL",{"date":104,"type":102},"2026-01-01",{"date":106,"type":92},"2030-12-31",{"name":5,"class":6},1]