[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582424":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":165,"collaborators":168,"id":171,"slug":172,"hasResults":173,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":173,"sex":179,"minAge":180,"maxAge":24,"enrollmentInfo":181,"targetDuration":24,"studyType":184,"phases":185,"briefSummary":187,"conditions":188,"keywords":24,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},{"fullName":5,"class":6},"McMaster University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Resection and Reconstruction","EXPERIMENTAL","If a participant is randomized to the Resection and Reconstruction treatment arm, a proximal femoral resection or hip arthroplasty will be carried out as per standard surgical practice. The type of endoprosthesis used for reconstruction will be at the treating surgeon's discretion. Acetabular reconstruction (if any), the surgical approach, and the intra-operative use of cement and other adjuvants for disease control will also be at the discretion of the treating surgeon.",[13],"Procedure: Resection and reconstruction",{"label":15,"type":16,"description":17,"interventionNames":18},"Internal Fixation","ACTIVE_COMPARATOR","If the participant is randomized to the Internal Fixation treatment arm, the surgery will involve the stabilization of the remaining bone with either an intramedullary nail, plate or screw fixation. All standard surgical principles of stable internal fixation will be followed. The type of fixation, the surgical approach, and the intra-operative use of cement and other adjuvants for disease control will be at the treating surgeon's discretion.",[19],"Procedure: Internal Fixation",[21,25],{"type":22,"name":15,"description":15,"armGroupLabels":23,"otherNames":24},"PROCEDURE",[15],null,{"type":22,"name":26,"description":26,"armGroupLabels":27,"otherNames":24},"Resection and reconstruction",[9],[29],{"name":30,"affiliation":5,"role":31},"Michelle Ghert, MD","PRINCIPAL_INVESTIGATOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Olivia Virag, MA","CONTACT","905- 521-2100","47105","viragoe@mcmaster.ca",{"name":40,"role":35,"phone":36,"phoneExt":37,"email":41},"Hadia Farrukh","farrukhh@mcmaster.ca",[43,64,82,104,121,146],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Parkview Packnett Family Cancer Institute","RECRUITING","Fort Wayne","Indiana","46845","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-85.12886,41.1306,{"lat":55,"lon":54},[58,62],{"name":59,"role":35,"phone":60,"phoneExt":24,"email":61},"Ashley Romine","260-266-9156","ashley.romine@parkview.com",{"name":63,"role":31,"phone":24,"phoneExt":24,"email":24},"Chris Johnson",{"facility":65,"status":45,"city":66,"state":67,"zip":68,"country":49,"countryCode":50,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Good Samaritan Regional Medical Center","Corvallis","Oregon","97330",{"type":52,"coordinates":70},[71,72],-123.26204,44.56457,{"lat":72,"lon":71},[75,79],{"name":76,"role":35,"phone":77,"phoneExt":24,"email":78},"Nicholas Tedesco, MD","541-768-4810","nicholas.tedesco@gmail.com",{"name":80,"role":35,"phone":24,"phoneExt":24,"email":81},"Anthony Franklin","Anfranklin@samhealth.org",{"facility":83,"status":84,"city":85,"state":67,"zip":86,"country":49,"countryCode":50,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Oregon Health and Science University Hospital","NOT_YET_RECRUITING","Portland","97239",{"type":52,"coordinates":88},[89,90],-122.67621,45.52345,{"lat":90,"lon":89},[93,97,99,102],{"name":94,"role":35,"phone":95,"phoneExt":24,"email":96},"Rebecca Smith","503-494-2963","smithreb@ohsu.edu",{"name":98,"role":31,"phone":24,"phoneExt":24,"email":24},"Kenneth Gundle",{"name":100,"role":101,"phone":24,"phoneExt":24,"email":24},"Yee-Cheen Doung, MD","SUB_INVESTIGATOR",{"name":103,"role":101,"phone":24,"phoneExt":24,"email":24},"Duncan Ramsey, MD",{"facility":105,"status":84,"city":106,"state":24,"zip":107,"country":108,"countryCode":109,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Cliniques Universitaires Saint-Luc","Brussels","1200","Belgium","BE",{"type":52,"coordinates":111},[112,113],4.34878,50.85045,{"lat":113,"lon":112},[116,119],{"name":117,"role":35,"phone":24,"phoneExt":24,"email":118},"Kim Henquin","kim.henquin@saintluc.uclouvain.be",{"name":120,"role":31,"phone":24,"phoneExt":24,"email":24},"Thomas Schubert",{"facility":122,"status":45,"city":123,"state":124,"zip":125,"country":126,"countryCode":127,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Hospital de Clínicas de Porto Alegre","Porto Alegre","Rio Grande do Sul","90450050","Brazil","BR",{"type":52,"coordinates":129},[130,131],-51.23019,-30.03283,{"lat":131,"lon":130},[134,138,140,142,144],{"name":135,"role":35,"phone":136,"phoneExt":24,"email":137},"Julie Cerutti Pestilho","+5551983081317","juliecerutti@gmail.com",{"name":139,"role":31,"phone":24,"phoneExt":24,"email":24},"Ricardo Becker",{"name":141,"role":101,"phone":24,"phoneExt":24,"email":24},"Bruno Pereira Antunes",{"name":143,"role":101,"phone":24,"phoneExt":24,"email":24},"Eduardo da Silva Rodrigues",{"name":145,"role":101,"phone":24,"phoneExt":24,"email":24},"Gabriella Moojen",{"facility":147,"status":84,"city":148,"state":149,"zip":150,"country":151,"countryCode":152,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"AOU Città della Salute e della Scienza CTO hospital","Torino","To","10126","Italy","IT",{"type":52,"coordinates":154},[155,156],11.99138,44.88856,{"lat":156,"lon":155},[159,163],{"name":160,"role":35,"phone":161,"phoneExt":24,"email":162},"Simone De Meo","+390116933962","Sdemeo@cittadellasalute.to.it",{"name":164,"role":31,"phone":24,"phoneExt":24,"email":24},"Michele Boffano",{"type":166,"investigatorFullName":30,"investigatorTitle":167,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Professor",[169],{"name":170,"class":6},"Canadian Cancer Society (CCS)","100582424","proximal-femur-reconstruction-or-internal-fixation-for-metastases-perform-trial-100582424",false,"NCT06863129","Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial","Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Randomized Controlled Trial","PERFORM","Inclusion Criteria:\n\n* Life expectancy of at least 6 months\n* Lesions in the proximal femur (femoral neck, intertrochanteric region, subtrochanteric region, and combinations thereof)\n* Low or intermediate risk for perioperative morbidity and\u002For mortality\n* No more than 75% and no less than 25% bone loss\n* Mutual (patient and physician) decision to perform surgical management of an impending or realized pathologic fracture due to MBD of the proximal has been made.\n\nExclusion Criteria:\n\n* Lesions isolated to the femoral neck\n* Lesion with any femoral head involvement\n* High risk for perioperative morbidity and\u002For mortality\n* Multidisciplinary decision that resection of the entire lesion would be indicated","ALL","18 Years",{"count":182,"type":183},334,"ESTIMATED","INTERVENTIONAL",[186],"NA","The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are:\n\n1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware?\n2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking?\n\nResearchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems.\n\nParticipants will:\n\n* Be randomly assigned to one of two groups (internal fixation or resection and reconstruction).\n* Have one of the two surgeries based on which group they're in.\n* Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.",[189],"Metastatic Bone Disease","2025-11-07",{"date":192,"type":193},"2025-11-10","ACTUAL",{"date":195,"type":193},"2025-02-01",{"date":197,"type":183},"2030-06-01",{"name":30,"class":6},6]