[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640513":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":27,"locations":33,"responsibleParty":51,"collaborators":24,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":24,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":84,"whyStopped":24,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Perineuroma Cryoablation","EXPERIMENTAL","Ultrasound-guided cryoablation performed adjacent to the painful neuroma.",[13],"Procedure: Perineuroma Cryoablation",{"label":15,"type":16,"description":17,"interventionNames":18},"Proximal Nerve Cryoablation","ACTIVE_COMPARATOR","Ultrasound-guided cryoablation performed proximal to the neuroma along the affected nerve.",[19],"Procedure: Proximal Nerve Cryoablation",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"PROCEDURE",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Dmytro Dmytriiev, PhD.Professor","CONTACT","+380674309449","mddmytriiev@gmail.com",[34],{"facility":35,"status":24,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Vinnitsya university hospital","Vinnytsia","Вінницька","21000","Ukraine","UA",{"type":42,"coordinates":43},"Point",[44,45],28.46871,49.2322,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":50,"phoneExt":24,"email":32},"Dmytro Dmytriiev, Phd","0674309449",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","PhD, Professor","100640513","proximal-nerve-cryoablation-versus-perineuroma-cryoablation-for-chronic-neuroma-pain-after-combat-related-amputation-100640513",false,"NCT07618689","Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation","AXON-FREEZE","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average pain intensity ≥4\u002F10 on Numeric Rating Scale\n* Positive Tinel sign\n* Ability to undergo ultrasound-guided cryoablation\n* Stable analgesic regimen for at least 14 days\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the treatment site\n* Open wound preventing safe procedure\n* Previous cryoablation of the target nerve within 6 months\n* Neuroma surgery within 3 months\n* Severe coagulopathy or anticoagulation contraindicating procedure\n* Pregnancy or breastfeeding\n* Severe uncontrolled systemic disease\n* Inability to complete follow-up assessments","ALL","18 Years","60 Years",{"count":66,"type":67},50,"ESTIMATED","INTERVENTIONAL",[70],"NA","atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Cryoablation is a minimally invasive treatment that produces controlled nerve injury using extreme cold. Although the freezing effect is localized around the cryoprobe, axonal interruption followed by distal Wallerian degeneration may extend functional denervation distal to the ablation site.\n\nThis study aims to compare two ultrasound-guided cryoablation strategies for chronic neuroma pain after combat-related amputation: cryoablation performed directly near the neuroma and cryoablation performed proximal to the neuroma along the affected nerve.\n\nThe study will evaluate whether proximal nerve cryoablation produces greater or longer-lasting analgesic effects compared with perineuroma cryoablation.",[73,74],"Neuroma","Cryoablation",[74,76,77,78,79,80,81,82,83],"neuroma pain","combat-related amputation","phantom limb pain","residual limb pain","peripheral nerve injury","Wallerian degeneration","ultrasound-guided intervention","military trauma","NOT_YET_RECRUITING","2026-05-30",{"date":87,"type":88},"2026-06-02","ACTUAL",{"date":90,"type":67},"2026-10-15",{"date":90,"type":67},{"name":5,"class":6},1]