[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620022":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":68,"collaborators":71,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Gujranwala medical college District Headquarters Hospital, Gujranwala","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Laser + PRP arm","EXPERIMENTAL","Participants receive fractional CO₂ laser treatment followed by the application of autologous platelet-rich plasma (PRP). Three sessions are administered at four-week intervals. PRP is prepared using a double-spin centrifugation method and applied topically immediately after laser treatment.",[13],"Procedure: Fractional CO₂ Laser + Platelet-Rich Plasma (PRP)",{"label":15,"type":10,"description":16,"interventionNames":17},"Laser only arm","Participants receive fractional CO₂ laser treatment alone, without PRP. Three sessions are administered at four-week intervals using the same laser parameters as the intervention group. To maintain masking, a placebo-filled syringe covered with opaque tape is touched to the skin without delivering PRP.",[18],"Procedure: Fractional CO₂ Laser Only",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Fractional CO₂ Laser + Platelet-Rich Plasma (PRP)","Fractional CO₂ Laser + Platelet-Rich Plasma (PRP)\n\nParticipants receive fractional CO₂ laser treatment followed by topical application of autologous platelet-rich plasma. Three treatment sessions are performed at four-week intervals. PRP is prepared using a standardized double-spin centrifugation method from 10 mL of the participant's blood. After laser resurfacing, the PRP is applied immediately to the treated area to enhance healing and collagen remodeling.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Fractional CO₂ Laser Only","Fractional CO₂ Laser Only\n\nParticipants receive fractional CO₂ laser treatment alone, with the same laser settings and treatment schedule as the intervention group. Three sessions are performed at four-week intervals. To maintain participant blinding, a placebo-filled syringe covered with opaque tape is applied to the skin without delivering PRP.",[15],[31],{"name":32,"affiliation":33,"role":34},"YASAAN SAAQIB","Gujranwala Medial College Gujranwala","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"YASAAN SAAQIB, MBBS","CONTACT","0923234525277","saani1992222@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":44},"Nabeela Shahzadi","+92 331 4218784","nabeela.pk82@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Destrict Head Quarter Hospital, Gujranwala","RECRUITING","Gujranwala","Punjab Province","52250","Pakistan","PK",{"type":55,"coordinates":56},"Point",[57,58],74.18705,32.15567,{"lat":58,"lon":57},[61,66],{"name":62,"role":38,"phone":63,"phoneExt":64,"email":65},"Syed Asif Ali, MS Artho","055-6705800-4","119","principal@gmcg.edu.pk",{"name":67,"role":38,"phone":43,"phoneExt":25,"email":44},"Nabeela Shahzadi, FCPS Derma",{"type":34,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Yasaan Saaqib","Principal investigator",[72],{"name":73,"class":6},"Saglik Bilimleri Universitesi","100620022","prp-plus-fractional-co-laser-for-acne-scars-100620022",false,"NCT07352215","PRP Plus Fractional CO₂ Laser for Acne Scars","Evaluating the Effectiveness of Platelet-Rich Plasma as an Adjunct to Fractional Carbon Dioxide Laser Therapy in Improving Facial Acne Scar Appearance: A Randomized Controlled Trial","PRPLT","Inclusion Criteria:Adults aged 18 to 40 years\n\nMale and female participants\n\nFitzpatrick skin types I to V\n\nPresence of moderate-to-severe acne scars\n\nWilling to undergo 3 treatment sessions and follow-up visits\n\nAble to provide informed consent -\n\nExclusion Criteria:Use of topical anti-acne medications in the past 1 month\n\nHistory of keloid formation or hypertrophic scarring\n\nActive acne or active skin inflammation at treatment area\n\nDiabetes mellitus\n\nPhotosensitive disorders (e.g., lupus, dermatomyositis)\n\nMelasma\n\nActive infections (e.g., Herpes simplex)\n\nRecent laser resurfacing or similar procedures\n\nOutdoor workers with high sun exposure\n\nVitiligo\n\nPregnancy or breastfeeding\n\nBleeding disorders or anticoagulant therapy\n\nUnrealistic expectations or inability to comply with follow-up\n\n\\-","ALL","18 Years","40 Years",{"count":86,"type":87},70,"ESTIMATED","INTERVENTIONAL",[90],"NA","This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.\n\nThe primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \\\u003C 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.",[93,94,95],"Post-Acne Atrophic Scars","Carbon Dioxide Lasers","Platelet-Rich Plasma",[97,98,99,100],"Post-acne Scarring","Fractional CO₂ Laser","PRP Therapy","Skin Resurfacing","2026-01-11",{"date":103,"type":104},"2026-01-20","ACTUAL",{"date":106,"type":104},"2025-10-31",{"date":108,"type":87},"2026-04-30",{"name":5,"class":6},1]