[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462639":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":18,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":18,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":18,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ACT Group Intervention","ACTIVE_COMPARATOR","We will evaluate the effects of an Acceptance and Commitment Therapy (ACT) one-day group intervention (with 1-month post group zoom booster session) on the functional near-infrared spectroscopy (fNIRS) signal in groups of adolescents and adult patients diagnosed with CPSP at \\>3 months post major orthopedic surgery.",[13],"Behavioral: Acceptance and Commitment Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment as Usual","NO_INTERVENTION","Treatment as Usual (TAU) for those with CPSP",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Acceptance and Commitment Therapy","The aim of ACT is to address avoidance behaviors by increasing openness to difficult experiences, such as pain, and to develop an awareness of behavioral options that will aid to facilitate behavior change processes that are in accord with living a values-based life.",[9],[26],{"name":27,"affiliation":5,"role":28},"Christine B. Sieberg","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Christine B Sieberg, PhD","CONTACT","6177261654","csieberg@mgh.harvard.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.05977,42.35843,{"lat":47,"lon":46},[50],{"name":31,"role":32,"phone":18,"phoneExt":18,"email":34},{"type":28,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Christine B. Sieberg, PhD","Associate Professor of Psychology, Department of Psychiatry, Harvard Medical School","100462639","psychophysical-and-neural-mechanisms-contributing-to-chronic-post-surgical-pain-in-adolescents-and-adults-100462639",false,"NCT05304286","Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults","Inclusion Criteria:\n\n--Females and males aged 12 and older who have previously undergone surgery at least 6 months ago and have chronic post surgical pain (3 months after surgery or longer)\n\nExclusion Criteria:\n\n* Inability to speak sufficient English or another language that can be interpreted orally and for questionnaires with the research team\n* Severe cognitive impairment by history (e.g., intellectual disability, severe head injury)\n* Patients with significant psychiatric disorders\n* Use of illegal hard drugs including MDMA, heroin, methamphetimes, amphetamines, cocaine, ketamine, benzodiazepines, and phencyclidine. Absence of such drugs will be confirmed in a urine drug screen during the visit. If prescription medication includes any of these compounds, that medication is not exclusionary.","ALL","12 Years",{"count":63,"type":64},110,"ESTIMATED","INTERVENTIONAL",[67],"NA","The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobiological pain mechanism(s) active in CPSP, particularly those non-responsive to current therapies, may be used to validate novel strategies both pharmacological and non-pharmacological.",[70],"Chronic Post-surgical Pain","2025-10-31",{"date":73,"type":74},"2025-11-03","ACTUAL",{"date":76,"type":74},"2022-04-07",{"date":78,"type":64},"2026-06-30",{"name":5,"class":6},1]