[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616722":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":36,"responsibleParty":54,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":24,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Université du Québec a Montréal","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"Cognitive Remediation Training","EXPERIMENTAL",[12],"Behavioral: Cognitive Remediation Training",{"label":14,"type":15,"description":16,"interventionNames":17},"Video Games with Life Quality Support","PLACEBO_COMPARATOR","Video Games with Quality of Life Support",[18],"Other: Control Group",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Cognitive Remediation Training: Eight-week remote program using HAPPYneuron Pro software targeting attention, verbal memory, processing speed, and executive functions.\n\nParticipants attend weekly 75-minute group sessions (four to eight participants) via videoconferencing: 30 minutes of computerized cognitive exercises and 45 minutes of guided discussion on metacognitive strategies and quality-of-life topics. Weekly homework assignments (45 minutes) reinforce skills. Sessions target attention (selective, sustained, divided), verbal memory (encoding, recall, recognition), and executive functions (planning, problem-solving, cognitive flexibility, inhibition).\n\nStrategy teachings address attention, verbal memory, planning, problem-solving, emotion regulation, meditation, and cognitive flexibility. Quality of life discussions (summarized format) cover sleep, nutrition, physical activity, social support, cultural activities, nature-based activities, relaxation, and substance use behaviors.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Control Group","Video Games with Quality of Life Support: Eight-week active control program combining commercial video games with quality of life discussions. Participants will attend weekly 75-minute group sessions via secure videoconferencing (four to eight participants) , consisting of 30 minutes of entertaining computer games from the Poki.com platform (games include Bubbles, Sweet World, Minesweeper, etc.) and 45 minutes of group discussions on healthy lifestyle topics including sleep, nutrition, physical activity, social support, cultural activities, nature-based activities, relaxation, and substance use behaviors. Weekly individual gaming assignments (30 minutes) maintain engagement. Games are selected for entertainment value without proven cognitive benefits. Discussions focus on general wellness and lifestyle factors rather than cognitive strategy development.",[14],[30],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Pascale Brillon Principal Investigator, Ph.D.","CONTACT","(514) 987-3000","2313","brillon.pascale@uqam.ca",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Pavillon Adrien-Pinard (SU)","RECRUITING","Montreal","Quebec","H2X 3P2","Canada","CA",{"type":46,"coordinates":47},"Point",[48,49],-73.58781,45.50884,{"lat":49,"lon":48},[52],{"name":53,"role":32,"phone":33,"phoneExt":34,"email":35},"Pascale Brillon Principal Investigator",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Pascale Brillon, Ph.D.","Principal Investigator","100616722","psychosocial-factors-and-efficacy-of-remote-cognitive-remediation-for-post-traumatic-stress-disorder-100616722",false,"NCT07309302","Psychosocial Factors and Efficacy of Remote Cognitive Remediation for Post-Traumatic Stress Disorder","Psychosocial Determinants and Impact of a Synchronous Remote Cognitive Remediation Program on Individuals With Post-Traumatic Stress Disorder.","Inclusion Criteria\n\n* Age 18 to 45 years\n* Able to speak and read French fluently\n* Access to a computer with a camera and a secure Internet connection\n* Access to a private space for assessment and intervention sessions\n* Available for the complete treatment protocol\n* Confirmed current PTSD diagnosis using the Structured Clinical Interview for DSM-5 (SCID-5)\n* Residing in Canada\n\nExclusion Criteria\n\n* History of neurological disorders (stroke, intracranial surgery, aneurysm, epilepsy)\n* Moderate to severe traumatic brain injury OR hospitalization due to traumatic brain injury\n* Mild traumatic brain injury less than 6 months ago with persistent symptoms\n* Psychotic disorders\n* Alcohol abuse or substance dependence disorders\n* Video game addiction\n* Hospitalization for major depression or suicide risk within the past 3 months\n* Regular use of medications that impact neurocognition, including: benzodiazepines (diazepam, lorazepam, alprazolam, Ativan, Xanax, Rivotril)\n* Residence outside Canada","ALL","18 Years","45 Years",{"count":69,"type":70},64,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to evaluate whether computer-based brain training can help adults with post-traumatic stress disorder (PTSD). Individuals with PTSD often experience difficulties with memory, attention, concentration, and problem-solving, which can significantly affect their daily lives, work performance, and overall quality of life. These cognitive challenges can hinder trauma recovery and reduce the effectiveness of standard PTSD treatments.\n\nThe main questions this study seeks to address are:\n\nDoes specialized brain training improve PTSD symptoms compared to regular computer games? Does brain training enhance cognitive functions such as memory, attention, processing speed, and executive functioning? Does brain training improve quality of life and daily functioning? Do participants' self-efficacy and perceived social support influence treatment outcomes?\n\nResearchers will compare two approaches: a specialized cognitive training program (HAPPYneuron Pro) with strategy teachings and quality-of-life discussions, versus engaging computer games with quality-of-life discussions, to determine which is more effective for people with PTSD.\n\nStudy Design\n\nParticipants will be randomly assigned to one of two groups for an 8-week program:\n\nCognitive remediation training group: Complete computerized cognitive exercises and strategy teachings specifically designed to strengthen memory, attention, and executive functions, combined with quality-of-life discussions.\n\nControl group: Complete engaging computer games combined with quality-of-life discussions.\n\nSchedule\n\nBoth groups will follow the same schedule:\n\nOne online session per week, in small and consistent groups of 4-8 participants. Each 60-minute session consists of 30 minutes of computer activities followed by 45 minutes of group discussion.\n\nOne at-home individual homework exercise per week (30 minutes at home).\n\nTotal time commitment: 1h45 per week for 8 weeks.\n\nAssessments All participants will complete three comprehensive assessment sessions: before treatment, immediately after the 8-week program, and 3 months later. Assessments include neuropsychological testing and questionnaires on PTSD symptoms, depression, anxiety, quality of life, satisfaction with life, social support, cognitive failures, and self-efficacy.\n\nSignificance This research evaluates a new, accessible and remotely deliverable approach for PTSD treatment. Current evidence-based treatments often do not directly target the cognitive impairments experienced by many individuals with PTSD.\n\nCompensation Participants will receive $35 for each completed assessment (maximum $105). Control group participants will gain access to the cognitive remediation training program after completing their participation.",[76],"Post Traumatic Stress Disorder PTSD",[78,79,80,81,82,83,84,85,86,87,88,89,90],"Cognitive remediation","Social Support","Quality of Life","Online Intervention","Self-Efficacy","Depression","Anxiety","Attention","Verbal Memory","Executive Functions","Life Satisfaction","Post-Traumatic Stress Disorder","Neuropsychological functions","2026-05-13",{"date":93,"type":94},"2026-05-18","ACTUAL",{"date":96,"type":94},"2025-08-03",{"date":98,"type":70},"2026-12",{"name":5,"class":6},1]