[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523519":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":59,"collaborators":37,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":37,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":87,"overallStatus":42,"whyStopped":37,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Texas at Austin","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immediate Treatment","EXPERIMENTAL","Those individuals randomized to immediate treatment will commence individual cognitive processing therapy (CPT) with an assigned study therapist, following the completion of baseline procedures.",[13],"Behavioral: Cognitive Processing Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Delayed Treatment","PLACEBO_COMPARATOR","Individuals randomized to the delayed treatment condition will be informed after randomization that their treatment will start in 6-8 weeks (the approximate period it will take for individuals in the immediate treatment arm to complete CPT and post-treatment assessments).",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Cognitive Processing Therapy","Cognitive processing therapy is a widely-utilized, empirically-supported treatment developed for PTSD. It is based on a cognitive theory of trauma which emphasizes the impact of trauma on belief systems and the development of \"stuck points\", which are unhealthy, unrealistic, and maladaptive ways of thinking that serve to maintain unhealthy beliefs and reinforce PTSD symptoms.",[15,9],[26],"CPT",[28],{"name":29,"affiliation":30,"role":31},"Gregory A Fonzo, PhD","The University of Texas at Austin","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Lauren Enten, B.S.A","CONTACT","512-495-5856",null,"fonzolab@austin.utexas.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600","RECRUITING","Austin","Texas","78712","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-97.74306,30.26715,{"lat":52,"lon":51},[55,57],{"name":56,"role":35,"phone":36,"phoneExt":37,"email":38},"Lauren Enten, B.S.A.",{"name":58,"role":31,"phone":37,"phoneExt":37,"email":37},"Greg Fonzo, Ph.D.",{"type":31,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Greg Fonzo","Assistant Professor","100523519","psychotherapy-effects-on-reward-processing-in-ptsd-100523519",false,"NCT06096740","Psychotherapy Effects on Reward Processing in PTSD","The Effects of Trauma-focused Psychotherapy on Reward Circuitry Function and Information Encoding","PERPP","Inclusion Criteria:\n\n* English as primary language, and comprehension suitable to understand experimenter instructions.\n* Current and chronic syndromic PTSD, defined as being exposed to a DSM-5 Criterion A traumatic event, with the presence DSM-5 qualifying PTSD symptoms for at least 3 months, as assessed by the Clinician-Administered PTSD Scale for DSM-5.\n* Able and willing to undergo functional magnetic resonance imaging (fMRI).\n* Willingness to participate in repeated assessments and as part of a delayed treatment group.\n\nExclusion Criteria:\n\n* Evidence of current or prior history of psychosis or bipolar disorder as evidenced by self-report or clinical interview.\n* Active substance dependence within the past 6 months as evidenced by clinical interview.\n* Current regular psychiatric medication use (i.e. antidepressants), except for as-needed benzodiazepine or opiate medication no more than three times per week, on average, or for short-duration stimulant medication for attention deficit hyperactivity disorder that can be skipped within 24 hours of study visits.\n* A recent (\\\u003C6 months) suicide attempt or current active ideation with intent.\n* Unremovable ferrous metal in body.\n* History of neurological disorder, stroke, seizures\u002Fconvulsions (except febrile seizures in childhood), epilepsy, brain surgery, electroconvulsive or radiation treatment, brain hemorrhage or tumor, or thyroid disorder.\n* Anyone who is pregnant or trying to become pregnant.\n* Current or past year (\\> 3 sessions), psychotherapy with a prominent exposure or cognitive restructuring component.\n* Previous or current (es)ketamine treatment and\u002F or brain stimulation\u002Fneuromodulation treatment.\n* Other ongoing treatment that is likely to confound experimental effects.\n* Previous penetrating head injury\u002Ftraumatic brain injury. Mild-to-moderate traumatic brain injury without penetrating injury is allowable.","ALL","18 Years","65 Years",{"count":74,"type":75},120,"ESTIMATED","INTERVENTIONAL",[78],"NA","The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD.",[81,82,83,84,85,86],"Post Traumatic Stress Disorder","Diminished Pleasure","Anhedonia","PTSD","Chronic PTSD","Chronic Post-Traumatic Stress Disorder",[84,88,89,26,22,90,85],"Post Traumatic Stress","Emotional Numbing","Therapy","2026-04-27",{"date":93,"type":94},"2026-05-01","ACTUAL",{"date":96,"type":94},"2024-06-01",{"date":98,"type":75},"2029-05-01",{"name":5,"class":6},1]