[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100111036":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":46,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":9,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":10,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"PPHN",null,"Infants born at \\>= 34 weeks who are diagnosed with clinical and\u002For echocardiographic evidence of PPHN",{"label":13,"type":10,"description":14,"interventionNames":10},"Control","Randomly selected, normal healthy infants born at \\>= 34 weeks gestational age and do not have PPHN",[16],{"name":17,"affiliation":5,"role":18},"G. Ganesh Konduri, MD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","414-266-6820","gkonduri@mcw.edu",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Kathleen M Meskin, BSN","414-337-7171","kmeskin@mcw.edu",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Children's Wisconsin","RECRUITING","Milwaukee","Wisconsin","53226","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-87.90647,43.0389,{"lat":41,"lon":40},[44],{"name":45,"role":18,"phone":10,"phoneExt":10,"email":10},"Ganesh Konduri, MD",{"type":18,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"G. Ganesh Konduri","Chair, Division of Neonatology","100111036","ptgs1-genetic-variation-and-increased-risk-for-persistent-pulmonary-hypertension-of-the-newborn-100111036",false,"NCT00710177","PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn","Prostaglandin G\u002FH Synthase-1 (PTGS1) Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn (PPHN)","Inclusion Criteria:\n\n* Infants born greater than or equal to 34 weeks gestational age diagnosed with PPHN and normal, healthy infants born greater than or equal to 34 weeks gestational age.\n\nExclusion Criteria:\n\n* Patients will be excluded if they are diagnosed with lethal congenital anomalies\n* structural congenital heart disease except presence of patent ductus arteriosus (PDA) or patent foramen ovale\n* structural gastrointestinal tract abnormality that could interfere with meconium passage\n* congenital anomalies such as diaphragmatic hernia, Potter's syndrome, or pulmonary hypoplasia",true,"ALL","12 Months",{"count":60,"type":61},200,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).",[65],"Persistent Pulmonary Hypertension of the Newborn",[9,67,68],"PTGS1","NSAID","2026-01-23",{"date":71,"type":72},"2026-01-26","ACTUAL",{"date":74,"type":10},"2006-01",{"date":76,"type":61},"2028-12",{"name":5,"class":6},1]