[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500361":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":27,"locations":37,"responsibleParty":57,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hvidovre University Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"None-mild ARDS",null,[12],"Procedure: Bronchoalveolar lavage",{"label":14,"type":10,"description":10,"interventionNames":15},"Moderate-severe ARDS",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Bronchoalveolar lavage","Bronchoalveolar lavage in the middle lobe of the right lung and a mini-bronchoalveolar lavage in the upper and lower lobe of the right lung",[14,9],[23],{"name":24,"affiliation":25,"role":26},"MD PhD Ronan berg","Biomedical Science of Health, University of Copenhagen","STUDY_CHAIR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"MD, PhD, Ronni Plovsing","CONTACT","+45386220721","ronni.thermann.reitz.plovsing.01@regionh.dk",{"name":34,"role":30,"phone":35,"phoneExt":10,"email":36},"MD Katrine Schneider","+4528118147","katrine.schneider@regionh.dk",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hvidovre Hospital, University of Copenhagen","RECRUITING","Hvidovre","2650","Denmark","DK",{"type":46,"coordinates":47},"Point",[48,49],12.47708,55.64297,{"lat":49,"lon":48},[52,55],{"name":53,"role":30,"phone":54,"phoneExt":10,"email":36},"Katrine Schneider, MD","+4521524590",{"name":56,"role":30,"phone":10,"phoneExt":10,"email":32},"Ronni Plovsing, MD, phD",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ronni R. Plovsing","Associate professor, Senior Consultant of ICU","100500361","pulmonary-immune-cell-microbiome-interactions-in-ards-100500361",false,"NCT05795257","Pulmonary Immune Cell-microbiome Interactions in ARDS","Pulmonary Immune Cell-microbiome Interactions in Acute Respiratory Distress Syndrome: the ILLUMINA-1 Study","ILLUMINA-1","Inclusion Criteria:\n\n* Inclusion criteria - moderate-to-severe ARDS\n* Admitted to the ICU at Hvidovre Hospital\n* Intubated within the past 72 hours\n* Moderate-to-severe ARDS according to the Berlin definition19\n* Age ≥ 18 years\n\nInclusion criteria - none-to-mild ARDS\n\n* Admitted to the ICU at Hvidovre Hospital\n* Intubated within the past 72 hours\n* None-to-mild ARDS according to the Berlin definition19\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* ARDS caused by COVID-19\n* Absolute contraindications for bronchoscopy\n* Untreated malignant arrhythmia\n* Documented or suspected intracranial hypertension (intracranial pressure ≥ \\> 15 mmHg)\n* One-lung ventilation\n* Severe coagulopathy","ALL","18 Years",{"count":72,"type":73},40,"ESTIMATED","OBSERVATIONAL","The overall aim is to compare the composition and spatial heterogeneity of the following in critically ill intensive care unit (ICU) patients: i) immune cell populations and their activation patterns, ii) the surrounding cytokine-chemokine milieu, including trans-compartmental fluxes of these mediators between the lung and bloodstream, and iii) the lung microbiome.\n\nMain hypotheses:\n\n* The immune cell population in bronchoalveolar lavage fluid (BALF) from patients with ARDS is dominated by neutrocytes, while T cells are depleted, and show evidence of hyper-activation and exhaustion\n* T cell hyper-activation and exhaustion is specifically compartmentalised to the lungs, and much more pronounced in moderate-to-severe than none-to-mild ARDS\n* Cyto- and chemokines derived from pulmonary immune cells are higher in moderate-to-severe than none-to-mild ARDS with a greater release from lungs to the bloodstream, notably of IL-6 and IL-8.\n* The differences in T cell profile in BALF, notably the ratio between regulatory T cells and T helper 17 cells, will change with disease severity over time, and can be explained by the presence of tI-IFN antibodies and\u002For a low microbial diversity of the respiratory tract with low enrichment from the oral cavity.",[77],"ARDS, Human","2025-03-13",{"date":80,"type":81},"2025-03-17","ACTUAL",{"date":83,"type":81},"2023-03-14",{"date":85,"type":73},"2028-11-30",{"name":5,"class":6},1]