[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504308":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":27,"locations":37,"responsibleParty":56,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Hvidovre University Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Women",null,[12],"Procedure: Bronchoalveolar lavage",{"label":14,"type":10,"description":10,"interventionNames":15},"Men",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Bronchoalveolar lavage","Bronchoalveolar lavage in the middle lobe of the right lung and a mini-bronchoalveolar lavage in the upper and lower lobe of the right lung",[14,9],[23],{"name":24,"affiliation":25,"role":26},"Ronan Berg, MD PhD","Biomedical Science of Health, University of Copenhagen","STUDY_CHAIR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Ronni Plovsing, MD, PhD","CONTACT","+45386220721","ronni.thermann.reitz.plovsing.01@regionh.dk",{"name":34,"role":30,"phone":35,"phoneExt":10,"email":36},"Katrine Schneider, MD","+4528118147","katrine.schneider@regionh.dk",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hvidovre Hospital, University of Copenhagen","RECRUITING","Hvidovre","2650","Denmark","DK",{"type":46,"coordinates":47},"Point",[48,49],12.47708,55.64297,{"lat":49,"lon":48},[52,54],{"name":34,"role":30,"phone":53,"phoneExt":10,"email":36},"+4521524590",{"name":55,"role":30,"phone":10,"phoneExt":10,"email":32},"Ronni Plovsing, MD, phD",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ronni R. Plovsing","Associate professor, Senior Consultant of ICU","100504308","pulmonary-immune-cell-microbiome-interactions-in-the-healthy-lung-100504308",false,"NCT05846620","Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung","Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung: the ILLUMINA-2 Study","ILLUMINA-2","Inclusion Criteria:\n\n* Men and women\n* Age 40 to 75\n\nExclusion Criteria:\n\n* Immune deficiency\n* Lung disease\n* Active cancer or infection\n* Absolute contraindications for bronchoscopy\n\n  * Untreated malignant arrhythmia\n  * Documented or suspected intracranial hypertension (intracranial pressure ≥ \\> 15 mmHg)\n  * One-lung ventilation\n  * Severe coagulopathy","ALL","40 Years","75 Years",{"count":72,"type":73},50,"ESTIMATED","OBSERVATIONAL","The overall aim is to to provide a normal material for the composition and spatial heterogeneity of the following in the healthy lung: i) immune cell populations and their activation patterns, ii) the surrounding cytokine-chemokine milieu, including trans-compartmental fluxes of these mediators between the lung and bloodstream, and iii) the lung microbiome.\n\nMain hypotheses:\n\n* Absolute and relative immune cell counts in bronchoalveolar lavage fluid (BALF) are similar to those previously reported by other methods6,7.\n* No trans-compartmental flux of cytokines between the lungs and bloodstream is present, but cytokine concentrations (notably IL-6 and IL-8) vary with the immune-cell-microbiome composition.\n* Immune cell (mainly T cell) activation, differentiation, and gene expression patterns are expected to differ between blood and BALF in a manner that depends on the regional diversity of the pulmonary microbiome.",[77],"Healthy",[79],"healthy lung, lung microbiota, microbiome","2025-03-13",{"date":82,"type":83},"2025-03-17","ACTUAL",{"date":85,"type":83},"2023-04-17",{"date":87,"type":73},"2028-11-30",{"name":5,"class":6},1]