[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611173":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":35,"responsibleParty":54,"collaborators":56,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":10,"maxAge":68,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":81,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Zurich","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Preterm infants with a gestational age \u003C 30 0\u002F7 weeks at birth",null,"Infants on sNIPPV respiratory support and below 4 weeks chronological age",[13],"Device: Electrical Impedance Tomography (EIT)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Electrical Impedance Tomography (EIT)","Electrical Impedance Tomography and clinical data will be recorded continuously. Corresponding data will be extracted and analyzed at five pre-defined timepoints.",[9],[21],{"name":22,"affiliation":23,"role":24},"Vincenzo Cannizzaro, MD","Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland","STUDY_CHAIR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Christoph M Rüegger, MD","CONTACT","+41432539810","christoph.rueegger@usz.ch",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Claudia Knöpfli","+41442555340","claudia.knoepfli@usz.ch",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University Hospital Zurich","RECRUITING","Zurich","Canton of Zurich","8091","Switzerland","CH",{"type":45,"coordinates":46},"Point",[47,48],8.55,47.36667,{"lat":48,"lon":47},[51,52],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},{"name":32,"role":28,"phone":53,"phoneExt":10,"email":34},"+41 44 255 53 40",{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[57],{"name":58,"class":6},"University Hospital, Zürich","100611173","pulmonary-volume-changes-during-synchonized-noninvasive-positive-pressure-ventilation-100611173",false,"NCT07237139","Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation","Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants","INSPIRE","Inclusion Criteria:\n\n* Written informed consent by one or both parents or legal guardians\n* Gestational age at birth \\\u003C 30 0\u002F7 weeks\n* Infants on sNIPPV respiratory support\n* Below 4 weeks chronological age\n\nExclusion Criteria:\n\n* Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)\n* Too ill\u002Funstable in the opinion of the treating physician.","ALL","4 Weeks",{"count":70,"type":71},27,"ESTIMATED","OBSERVATIONAL","Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.",[75,76,77,78,79,80],"Infant, Preterm","Respiratory Distress Syndrome (Neonatal)","Chronic Lung Disease of Newborn","Respiratory Support","Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)","Lung Volume",[82,83,17,84],"Synchronized noninvasive positive pressure ventilation (SNIPPV)","Lung volume","infant, preterm","2025-12-08",{"date":87,"type":88},"2025-12-09","ACTUAL",{"date":90,"type":88},"2025-11-17",{"date":92,"type":71},"2027-01-30",{"name":5,"class":6},1]