[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636574":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":42,"centralContacts":43,"locations":50,"responsibleParty":87,"collaborators":90,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":121,"sex":127,"minAge":128,"maxAge":42,"enrollmentInfo":129,"targetDuration":42,"studyType":132,"phases":133,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":53,"whyStopped":42,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},{"fullName":5,"class":6},"Queen Elizabeth Hospital, Hong Kong","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group A","EXPERIMENTAL","Use of pulsatile flushing technique (0.4s pause interval)",[13],"Device: Pulsatile Flushing Technique (0.4s pause interval)",{"label":15,"type":10,"description":16,"interventionNames":17},"Intervention Group B","Use of pulsatile flushing technique (1s pause interval)",[18],"Other: Pulsatile Flushing Technique (1s pause interval)",{"label":20,"type":21,"description":22,"interventionNames":23},"Control Group","ACTIVE_COMPARATOR","Standard bolus flushing technique",[24],"Device: Bolus Flushing Technique",[26,33,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Pulsatile Flushing Technique (0.4s pause interval)","Pulsatile flushing technique consists of multiple small boluses injected intermittently with 0.4-second pauses between each bolus resulting in unsteady turbulent flow, performed by a renal nurse who passed a formal train-the-trainer program on \"pulsatile flushing technique\" taught and assessed by designated nurse consultant (renal care).",[9],[32],"Catheter Care Simulation System",{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Pulsatile Flushing Technique (1s pause interval)","Pulsatile flushing technique consists of multiple small boluses injected intermittently with 1-second pauses between each bolus resulting in unsteady turbulent flow, performed by a renal nurse who passed a formal train-the-trainer program on \"pulsatile flushing technique\" taught and assessed by designated nurse consultant (renal care).",[15],[32],{"type":27,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Bolus Flushing Technique","Bolus flushing technique involves the continuous administration of a single, concentrated volume of flush solution resulting in consistent laminar flow",[20],null,[44],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"SUNG Ka Ming Dorothy, KCC NC (Renal Care)","CONTACT","852-3506","6507","bskmd01@ha.org.hk",[51],{"facility":52,"status":53,"city":54,"state":42,"zip":42,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Queen Elizabeth Hospital","RECRUITING","Kowloon","Hong Kong","HK",{"type":58,"coordinates":59},"Point",[60,61],114.18333,22.31667,{"lat":61,"lon":60},[64,66,68,71,73,75,77,79,81,83,85],{"name":65,"role":46,"phone":47,"phoneExt":48,"email":49},"Ka Ming Dorothy SUNG, KCC NC (Renal Care)",{"name":65,"role":67,"phone":42,"phoneExt":42,"email":42},"PRINCIPAL_INVESTIGATOR",{"name":69,"role":70,"phone":42,"phoneExt":42,"email":42},"Kai Cheong Harris LAM, HOCS M(N)\u002F CNO","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":42,"phoneExt":42,"email":42},"Suet Lai TAM, KWH NC (Renal Care)",{"name":74,"role":70,"phone":42,"phoneExt":42,"email":42},"Ngar Yee CHOW, NTEC NC (Renal Care)",{"name":76,"role":70,"phone":42,"phoneExt":42,"email":42},"Hau Sim Eva HO, HKEC NC (Renal Care)",{"name":78,"role":70,"phone":42,"phoneExt":42,"email":42},"May Ki LAM, QMH NC (Renal Care)",{"name":80,"role":70,"phone":42,"phoneExt":42,"email":42},"Lai Nga PO, NTWC NC (Renal Care)",{"name":82,"role":70,"phone":42,"phoneExt":42,"email":42},"Shuk Hang LEE, KWC & PMH NC (Renal Care)",{"name":84,"role":70,"phone":42,"phoneExt":42,"email":42},"Har Ping CHEUNG, TKOH APN (MED)",{"name":86,"role":70,"phone":42,"phoneExt":42,"email":42},"Victor CHEUNG, QEH EOII (MDSSC)",{"type":67,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"SUNG Ka Ming Dorothy","Nurse Consultant (Renal Care)",[91,93,95,97,100,102,104,106,108,110,112,114,117],{"name":92,"class":6},"Kwong Wah Hospital",{"name":94,"class":6},"Prince of Wales Hospital, Shatin, Hong Kong",{"name":96,"class":6},"Alice Ho Miu Ling Nethersole Hospital",{"name":98,"class":99},"North District Hospital, Hong Kong","UNKNOWN",{"name":101,"class":6},"Caritas Medical Centre, Hong Kong",{"name":103,"class":6},"Queen Mary Hospital, Hong Kong",{"name":105,"class":6},"Tseung Kwan O Hospital, Hong Kong",{"name":107,"class":99},"Tin Shui Wai Hospital",{"name":109,"class":6},"Yan Chai Hospital",{"name":111,"class":6},"Tung Wah Hospital",{"name":113,"class":6},"Pamela Youde Nethersole Eastern Hospital",{"name":115,"class":116},"Tuen Mun Hospital","OTHER_GOV",{"name":118,"class":116},"Princess Margaret Hospital, Hong Kong","100636574","pulsatile-flushing-technique-in-reducing-blockage-of-t-cvad-for-haemodialysis-patients-100636574",false,"NCT07567456","Pulsatile Flushing Technique in Reducing Blockage of T-CVAD for Haemodialysis Patients","Exploring the Effectiveness of Pulsatile Flushing Technique in Reducing Blockage of the Tunnelled Central Venous Access Device Among Haemodialysis Patients in Multiple Renal Centres in Hong Kong: A Cluster Non-Randomised Controlled Trial Study","Non-RCT HD","Inclusion Criteria:\n\n* Patients undergoing HD treatment with Tunnelled Central Venous Access Device (T-CVAD) in the above collaborators under the Hospital Authority\n* Able to understand spoken and written Chinese or English\n\nExclusion Criteria:\n\n* Patients with Non-Tunnelled Central Venous Access Device (NT-CVAD)\n* Temporary dysfunction (e.g., kicking of the catheter) resolved with repositioning\n* Confirmed case of fibrin sheath occlusion which can only be resolved through surgical intervention\n* Non-thrombotic occlusion due to mechanical causes (e.g., catheter malposition)\n* Patient declined or incompetent to provide written informed consent.","ALL","18 Years",{"count":130,"type":131},591,"ESTIMATED","INTERVENTIONAL",[134],"NA","This study investigates the effectiveness of pulsatile flushing techniques in reducing blockage in Tunnelled Central Venous Access Device (T-CVAD) among patients undergoing haemodialysis (HD) treatment at multiple renal centres within the Hospital Authority (HA) in Hong Kong. With limitation in single service protocol for each cluster of renal units, it is designed as a prospective, parallel, cluster non-randomised controlled trial involving 591 patients from 14 renal units. In order to identify the most effective flushing technique for T-CVAD maintenance, survival analysis on clinical effectiveness, in terms time-to-event blockage of the T-CVAD, among three trial arms: 1) Intervention Group A (IG-A) using pulsatile flushing technique with 0.4 second pause time interval; 2) Intervention Group B (IG-B) using pulsatile flushing technique with 1 second pause time interval; 3) Control Group (Con) using standard bolus flushing technique. The findings facilitate development of best practice for T-CVAD maintenance, optimise T-CVAD maintenance protocols, and ultimately improve patient outcomes. This groundbreaking study is expected to signify substantial progression in the nursing management of HD and T-CVAD.",[137,138,139],"Haemodialysis Patients","Blockage of Tunnelled Central Venous Access Device","Pulsatile Flushing Technique",[141,142,139],"HD","T-CVAD","2026-05-05",{"date":145,"type":146},"2026-05-11","ACTUAL",{"date":148,"type":146},"2026-02-02",{"date":150,"type":131},"2027-12",{"name":5,"class":6},1]