[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638730":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":10,"overallStatus":80,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pulsed Field Ablation(PFA) Group",null,"Patients with persistent atrial fibrillation who undergo pulmonary vein isolation combined with left atrial posterior wall isolation using pulsed field ablation.",[13],"Procedure: Pulsed Field Ablation",{"label":15,"type":10,"description":16,"interventionNames":17},"Radiofrequency Ablation(RFA) Group","Patients with persistent atrial fibrillation who undergo pulmonary vein isolation combined with left atrial posterior wall isolation using radiofrequency ablation.",[18],"Procedure: Radiofrequency Ablation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Pulsed Field Ablation","Pulmonary vein Description isolation combined with left atrial posterior wall isolation using pulsed field ablation for persistent atrial fibrillation.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Radiofrequency Ablation","Pulmonary vein Description isolation combined with left atrial posterior wall isolation using radiofrequency ablation for persistent atrial fibrillation.",[15],[30],{"name":31,"affiliation":32,"role":33},"Fu Yi","The First Affiliated Hospital of Air Force Medicial University","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","+8613572100232","yi12fu56@126.com",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Zi Hao","+8618220244424","18220244424@163.com",[44],{"facility":45,"status":10,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Xijing Hospital, Air Force Medical University","Xi'an","Shaanxi","710032","China","CN",{"type":52,"coordinates":53},"Point",[54,55],108.92861,34.25833,{"lat":55,"lon":54},[58],{"name":31,"role":36,"phone":37,"phoneExt":10,"email":38},{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100638730","pulsed-field-ablation-versus-radiofrequency-ablation-effects-of-pulmonary-vein-isolation-combined-with-left-atrial-posterior-wall-isolation-on-postoperative-gastric-motility-in-patients-with-persistent-atrial-fibrillation-100638730",false,"NCT07612241","Pulsed Field Ablation Versus Radiofrequency Ablation: Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation","A Comparative Study on the Effects of Pulmonary Vein Isolation Combined With Left Atrial Posterior Wall Isolation Via Pulsed Field Ablation Versus Radiofrequency Ablation on Postoperative Gastric Motility in Patients With Persistent Atrial Fibrillation","PFA-GM","Inclusion Criteria:\n\n* Age 18-80 years\n* Diagnosed with persistent atrial fibrillation (AF) according to current guidelines\n* Undergoing first-time catheter ablation (PFA or RF) with planned pulmonary vein isolation plus left atrial posterior wall isolation\n* Able to understand and sign informed consent\n* Able to complete radionuclide gastric emptying scintigraphy and symptom questionnaires\n\nExclusion Criteria:\n\n* Previous AF ablation or cardiac surgery\n* History of gastroparesis or severe gastrointestinal disease\n* Prior upper gastrointestinal surgery\n* Use of prokinetic or antisecretory medications within 4 weeks before enrollment\n* Severe renal\u002Fhepatic dysfunction or active malignancy\n* Pregnant or breastfeeding women\n* Inability to comply with study procedures or follow-up","ALL","18 Years","80 Years",{"count":73,"type":74},20,"ESTIMATED","7 Days","OBSERVATIONAL","This is a single-center, prospective, matched cohort study comparing the effect of Pulsed Field Ablation (PFA) versus Radiofrequency Ablation (RF) on postoperative gastric motility in patients with persistent atrial fibrillation (AF). A total of 20 patients will be enrolled in a 1:1 matched design (10 PFA, 10 RF), matched by age, gender, left atrial diameter, AF duration, and diabetes history. All patients will undergo pulmonary vein isolation (PVI) plus left atrial posterior wall isolation (LAPWI).\n\nThe primary outcome is gastric emptying assessed by radionuclide imaging preoperatively and at 48 hours post-ablation. Secondary outcomes include gastrointestinal symptom scores: PAGI-SYM, GSRS, and GerdQ measured before ablation and at 7 days post-procedure.\n\nPatients with prior AF ablation, upper gastrointestinal surgery, gastroparesis, or recent use of gastrointestinal medications are excluded. The study period is from January 30, 2026 to July 30, 2026.\n\nThis study aims to evaluate whether PFA is associated with better gastric motility preservation compared with conventional RF ablation in persistent AF patients undergoing extended PVI plus posterior wall isolation.",[79],"Persistent Atrial Fibrillation","NOT_YET_RECRUITING","2026-05-28",{"date":83,"type":84},"2026-06-02","ACTUAL",{"date":86,"type":74},"2026-05-31",{"date":88,"type":74},"2026-12-31",{"name":5,"class":6},1]