[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576925":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":33,"responsibleParty":48,"collaborators":11,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":11,"enrollmentInfo":60,"targetDuration":11,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Beijing Anzhen Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Radiofrequency Ablation","ACTIVE_COMPARATOR",null,[13],"Device: Radiofrequency Ablation",{"label":15,"type":16,"description":11,"interventionNames":17},"Pulsed Field Ablation","EXPERIMENTAL",[18],"Device: Pulsed Field Ablation",[20,24],{"type":21,"name":15,"description":22,"armGroupLabels":23,"otherNames":11},"DEVICE","Patients will be treated with pulsed field ablation for atrial fibrillation.",[15],{"type":21,"name":9,"description":25,"armGroupLabels":26,"otherNames":11},"Patients will be treated with radiofrequency ablation for atrial fibrillation.",[9],[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Deyong Long","CONTACT","+86 135 2295 8166","dragon2008@vip.sina.com",[34],{"facility":35,"status":11,"city":36,"state":11,"zip":11,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Beijing Anzhen Hospital, Capital Medical University","Beijing","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":29,"role":30,"phone":47,"phoneExt":11,"email":32},"+86 13522958166",{"type":49,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100576925","pulsed-field-ablation-versus-radiofrequency-ablation-for-persistent-atrial-fibrillation-100576925",false,"NCT06791629","Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation","Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: A Randomized, Open-label, Non-inferior Study","PRAISE","Inclusion Criteria:\n\n* 18-80 years\n* Patients with non-valvular persistent atrial fibrillation undergoing their first catheter ablation (AF duration: 3 months to 3 years)\n* Left atrial diameter on parasternal long-axis view of echocardiogram \\\u003C 50 mm\n* Agree to be randomly assigned to the ablation strategy and able to follow up\n\nExclusion Criteria:\n\n* Atrial fibrillation due to reversible causes\n* LVEF \\\u003C 30%\n* Severe congenital heart disease\n* Severe liver or kidney dysfunction (eGFR \\\u003C 15, Child-Pugh grade 3), or history of dialysis\n* History of cardiac surgery, such as coronary artery bypass grafting, mechanical valve or prosthetic valve replacement\n* History of pacemaker implantation, left atrial appendage closure, or patent foramen ovale closure\n* Contraindications to oral anticoagulation\n* Contraindications to right or left heart catheterization\n* Pregnancy\n* Life expectancy \\\u003C 1 year (e.g., advanced malignancy, end-stage renal disease)\n* Currently enrolled in another trial evaluating medical devices or drugs\n* Other situations where the investigator determines the subject is unsuitable for the study","ALL","18 Years",{"count":61,"type":62},700,"ESTIMATED","INTERVENTIONAL",[65],"NA","This clinical trial aims to compare the efficacy and safety of pulsed field ablation and radiofrequency ablation to treat persistent atrial fibrillation in adults.\n\nParticipants will:\n\nUndergo pulsed field ablation or radiofrequency ablation. Keep follow-up for at least 12 months.",[68,69,15],"Persistent Atrial Fibrillation","Radiofrequency Catheter Ablation",[71,69,72],"persistent atrial fibrillation","pulsed field ablation","NOT_YET_RECRUITING","2025-01-23",{"date":76,"type":77},"2025-01-24","ACTUAL",{"date":79,"type":62},"2025-02-15",{"date":81,"type":62},"2027-02-15",{"name":5,"class":6},1]