[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613670":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":76,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (PRF Group)","ACTIVE_COMPARATOR","Group A (PRF Group): will Receive ultrasound-guided pulsed radiofrequency to the median nerve at the carpal tunnel.",[13],"Procedure: Pulsed Radiofrequency",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (HD Group)","Group B (HD Group): will Receive ultrasound-guided hydrodissection of the median nerve using hyaluronidase solution.",[18],"Procedure: Hyaluronidase Hydrodissection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Pulsed Radiofrequency","Pulsed Radiofrequency:\n\nTop neuropole needle 100-mm with a 10-mm active tip will be advanced with\n\nultrasound guidance using the in-plane technique towards the median nerve.\n\nSensory and motor stimulation will be tested when the needle is close to the median nerve.\n\nDuring sensory stimulation (50 Hz; 1-ms pulsed width; 0-3.0 volt), the patients will report paresthesia in the distal fingers.\n\nAfter performing a motor stimulation (2 Hz; 1-ms pulsed width; 0-3.0 volt), contractions of the thenar muscle will be observed.\n\nPRF lesion will then be carried out for 6 min, pulse width of 5 MS, 5 pulses per second and 35 volts at 42°C.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Hyaluronidase Hydrodissection","Hyaluronidase Hydrodissection:\n\nThe patient will sit facing the examiner with the forearm supinated and semiflexed at 90°, and the wrist placed on the examination couch with semi extended fingers. The injection for a 5 mL volume of HD 1500 IU will be done under complete sterile conditions. A 26-gauge needle will be introduced from the lateral side toward the midline, using the in-plane approach to target the median nerve in the carpal tunnel using the ulnar approach.\n\nUltrasonographic visualization of the needle tip will be continuous, the injection was done gradually, and the needle will be advanced dissecting the flexor retinaculum away from the median nerve via gradual drug infiltration.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Amany Mahmoud Mohamed, resident","CONTACT","01095062277","amany_mahmoud_post@med.sohag.edu.eg",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Faculty of Medicine Sohag University","Sohag","Sohag Governorate","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.69478,26.55695,{"lat":47,"lon":46},[50],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Amany Mahmoud Mohamed","Resident of Anesthesia, ICU and Pain management faculty of medicine, Sohag University","100613670","pulsed-radiofrequency-versus-hyaluronidase-hydrodissection-for-treatment-of-carpal-tunnel-syndrome-100613670",false,"NCT07269613","Pulsed Radiofrequency Versus Hyaluronidase Hydrodissection for Treatment of Carpal Tunnel Syndrome","Comparison of Ultrasound Guided Pulsed Radiofrequency Versus Hyaluronidase Hydrodissection for Treatment of Carpal Tunnel Syndrome, a Prospective, Randomized, Controlled Clinical Study","Inclusion Criteria:\n\n1. Adults aged 20-80 years\n2. Clinical diagnosis of CTS with symptoms for at least 3 months\n3. Electrophysiological evidence of mild to moderate CTS\n4. No previous intervention for CTS in the affected hand\n\nExclusion Criteria:\n\n1. Previous wrist surgery or trauma\n2. Medical history of polyneuropathy, thoracic outlet syndrome, or brachial plexopathy\n3. Coagulopathy or local infection at injection site\n4. Pregnancy or breastfeeding","ALL","20 Years","80 Years",{"count":66,"type":67},56,"ESTIMATED","INTERVENTIONAL",[70],"NA","The aim of this study is to compare the clinical efficacy and safety of ultrasound-guided pulsed radiofrequency and hyaluronidase hydrodissection in the treatment of carpal tunnel syndrome. This research seeks to evaluate both techniques in terms of pain relief, functional improvement, nerve conduction parameters, and potential complications, in order to identify the more effective minimally invasive approach for managing carpal tunnel syndrome.",[73],"Carpal Tunnel Syndrome (CTS)",[75],"pulsed radiofrequency versus hyaluronidase hydrodissection for treatment of carpal tunnel syndrome","NOT_YET_RECRUITING","2025-12-06",{"date":79,"type":80},"2025-12-09","ACTUAL",{"date":82,"type":67},"2025-12",{"date":84,"type":67},"2026-07",{"name":5,"class":6},1]