[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517302":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":31,"locations":36,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Men",null,"Men who are undergoing cardiac surgery",[13],"Other: Gender",{"label":15,"type":10,"description":16,"interventionNames":17},"Women","Women who are undergoing cardiac surgery",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Gender","Differences between men and women will be observed",[9,15],[24,28],{"name":25,"affiliation":26,"role":27},"Robina Matyal, MD","Beth Israel Deaconess Medical Center, Professor of Anesthesia","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":30,"role":27},"Simon Robson, MD, PhD","Beth Israel Deaconess Medical Center,Vice Chair Research",[32],{"name":25,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","6176401208","rmatyal1@bidmc.harvard.edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-71.05977,42.35843,{"lat":48,"lon":47},[51],{"name":25,"role":33,"phone":34,"phoneExt":10,"email":35},{"type":27,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Robina Matyal","Professor of Anesthesia","100517302","purinergic-signaling-and-the-postmenopausal-heart-100517302",false,"NCT06015776","Purinergic Signaling and the Postmenopausal Heart","PGC-1, Purines and the Postmenopausal Heart","Inclusion Criteria:\n\n* Patients undergoing cardiac surgery under cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Refusal to participate\n* Emergency surgery\n* Pre-existing heart block\n* Preexisting atrial fibrillation\n* Redo surgery\n* Estrogen or hormone replacement therapy\n* History of chronic heart failure\n* History of major kidney disease","ALL","30 Years","88 Years",{"count":66,"type":67},500,"ESTIMATED","OBSERVATIONAL","There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.",[71,72],"Diastolic Heart Failure","Heart Failure With Preserved Ejection Fraction","2026-03-18",{"date":75,"type":76},"2026-03-20","ACTUAL",{"date":78,"type":76},"2019-07-01",{"date":80,"type":67},"2030-06",{"name":5,"class":6},1]