[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613436":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":43,"centralContacts":47,"locations":53,"responsibleParty":69,"collaborators":51,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":51,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":51,"enrollmentInfo":80,"targetDuration":51,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":93,"whyStopped":51,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"Participants Receiving Botanicals","EXPERIMENTAL",[12,13,14,15,16],"Other: Placebo","Dietary Supplement: Pycnogenol, 100mg","Dietary Supplement: Pycnogenol, 200mg","Dietary Supplement: Pycnogenol, 400mg","Dietary Supplement: Pycnogenol, 600mg",[18,24,31,35,39],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Placebo","The placebo being used in this study is microcrystalline cellulose. This will be taken orally, up to twice per day.",[9],[23],"Microcrystalline Cellulose",{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DIETARY_SUPPLEMENT","Pycnogenol, 100mg","Pycnogenol being used in this study is a commercially available dietary supplement and is classified as food by the FDA instead of a drug. This will be taken orally, up to twice per day.",[9],[30],"French Maritime Pine Bark",{"type":25,"name":32,"description":27,"armGroupLabels":33,"otherNames":34},"Pycnogenol, 200mg",[9],[30],{"type":25,"name":36,"description":27,"armGroupLabels":37,"otherNames":38},"Pycnogenol, 400mg",[9],[30],{"type":25,"name":40,"description":27,"armGroupLabels":41,"otherNames":42},"Pycnogenol, 600mg",[9],[30],[44],{"name":45,"affiliation":5,"role":46},"Jarred Younger, PhD","PRINCIPAL_INVESTIGATOR",[48],{"name":45,"role":49,"phone":50,"phoneExt":51,"email":52},"CONTACT","205-975-5821",null,"younger@uab.edu",[54],{"facility":5,"status":51,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Birmingham","Alabama","35243","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-86.80249,33.52066,{"lat":64,"lon":63},[67,68],{"name":45,"role":49,"phone":50,"phoneExt":51,"email":52},{"name":45,"role":46,"phone":51,"phoneExt":51,"email":51},{"type":46,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":51,"oldOrganization":51},"Jarred Younger","Professor","100613436","pycnogenol-french-maritime-pine-bark-for-the-treatment-of-gulf-war-illness-100613436",false,"NCT07266571","Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness","Inclusion Criteria:\n\n* Meet the Kansas GWI case definition\n* Meet the CDC GWI case definition\n* Able to commit to a 12-month study\n* Male\n* Participants will be individuals in our Gulf War database who have already completed our other botanical trial, Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness (NCT05377242).\n\nExclusion Criteria:\n\n* Currently involved in another experimental treatment study\n* Female\n* Have a blood clotting disorder\n* Reported diagnosis of diabetes with a A1C greater than 9\n* Use of contraindicated medications (see below):\n* Anticoagulants (such as warfarin, heparin, etc.)\n* Lithium\n* Tacrolimus (Prograf)\n* Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)\n* Daily Use of Antiplatelet agents (e.g. aspirin, clopidogrel)\n* Nitroglycerin\n* Hypotension\n* Need for surgery during study period.","MALE","18 Years",{"count":81,"type":82},20,"ESTIMATED","INTERVENTIONAL",[85],"NA","The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage. The investigators believe that GWI involves inflammation in the body and brain that causes fatigue, pain, cognitive disruption, and other symptoms. Botanicals that reduce inflammation may help treat GWI.",[88],"Gulf War Syndrome",[90,91,92,30],"Gulf War Illness","Pycnogenol","Botanical","NOT_YET_RECRUITING","2026-06-15",{"date":96,"type":97},"2026-06-17","ACTUAL",{"date":99,"type":82},"2026-08-01",{"date":101,"type":82},"2027-08-01",{"name":5,"class":6},1]