[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644973":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":46,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":63,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Weill Cornell Medical College in Qatar","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Groupe 1: Controls (C)",null,"Non-diabetic patients, defined as having an HbA1c \\\u003C 5.7%, with established atherosclerotic cardiovascular disease (ASCVD) or very high cardiovascular risk",{"label":13,"type":10,"description":14,"interventionNames":10},"Groupe 2: Cases-1 (pre-D)","Patients with pre-diabetes, defined as having an HbA1c between 5.7≤HbA1C ≤6.4, with established atherosclerotic cardiovascular disease (ASCVD) or very high cardiovascular risk",{"label":16,"type":10,"description":17,"interventionNames":10},"Groupe 3: Cases-2 (T2D)","Patients with type 2 diabetes, defined as having an HbA1c ≥ 6.5%, with established atherosclerotic cardiovascular disease (ASCVD) or very high cardiovascular risk.",[19],{"name":20,"affiliation":21,"role":22},"Charbel Abi Khalil, MD,PhD","Weill Cornell Medicine-Qatar","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Charbel Abi khalil, MD,PhD","CONTACT","+974 4492 8484","cha2022@qatar-med.cornell.edu",[30],{"facility":31,"status":10,"city":32,"state":10,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Hamad Medical Corporation","Doha","Qatar","QA",{"type":36,"coordinates":37},"Point",[38,39],51.53096,25.28545,{"lat":39,"lon":38},[42],{"name":43,"role":26,"phone":44,"phoneExt":10,"email":45},"Jassim Al Suwaidi, MD","+974 4439 5354","jalsuwaidi@hamad.qa",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49],{"name":31,"class":50},"INDUSTRY","100644973","qatar-cardiometabolic-cohort-100644973",false,"NCT07675928","Qatar Cardiometabolic Cohort","Qatar Cardiometabolic Cohort (QCMC)","Inclusion Criteria:\n\n* Qataris\n* Long-term residents (≥15 years of residence in Doha) who are not planning to leave Qatar voluntarily within the next 5 years.\n* Age ≥18 years.\n* English or Arabic speaker.\n* Presence of either atherosclerotic cardiovascular disease (ASCVD) or very high cardiovascular risk.\n\n  1. ASCVD:\n\n     ASCVD is defined as either clinical ASCVD or unequivocally documented ASCVD on imaging, based on the European Society of Cardiology (ESC) guidelines for the management of cardiovascular disease in patients with diabetes.\n\n     i.Clinical ASCVD: History or presence of any of the following atherosclerotic events or revascularization in major arterial territories:\n     1. Coronary Artery Disease (CAD)\n\n        * Myocardial infarction (ST-elevation myocardial infarction (STEMI) or Non-ST-elevation myocardial infarction (NSTEMI))\n        * Stable or unstable angina with angiographic stenosis ≥50%\n        * History of coronary revascularization (Percutaneous coronary intervention (PCI) or Coronary artery bypass graft surgery (CABG))\n     2. Cerebrovascular Disease\n\n        * Ischemic stroke or transient ischemic attack (TIA)\n        * Symptomatic carotid artery stenosis ≥50% or prior carotid intervention\n     3. Peripheral Arterial Disease (PAD)\n\n        * Intermittent claudication with objective evidence of arterial obstruction\n        * Prior peripheral revascularization, limb amputation due to ischemia, or Ankle-brachial index ABI \\\u003C0.9\n     4. Aortic Atherosclerotic Disease •Aortic aneurysm (abdominal or thoracic) of atherosclerotic origin ii.Unequivocally Documented ASCVD on Imaging:\n\n     \u003C!-- -->\n\n     1. Coronary artery calcium (CAC) score \\>100 Agatston units or \\>75th percentile for age and sex\n     2. Coronary CT angiography or invasive angiography showing ≥50% stenosis in ≥1 major epicardial artery\n     3. Carotid ultrasound or angiography showing plaque or ≥50% stenosis\n     4. Lower-limb CT\u002FMR\u002FDoppler angiography showing atherosclerotic plaque or stenosis ≥50%\n  2. Very High Cardiovascular Risk i. In non-diabetic patients (ESC 2021 CVD Prevention Guidelines):\n\n     * 10-year fatal\u002Fnon-fatal ASCVD risk ≥10% using SCORE2 (ages 40-69), or ≥15% using SCORE2-OP (≥70 years)\n     * Severe chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) \\\u003C30 mL\u002Fmin\u002F1.73m² ii.In diabetic patients (ESC 2023 Diabetes \\& CVD Guidelines):\n     * 10-year cardiovascular risk ≥20% using SCORE2-Diabetes\n     * Severe target organ damage:\n\n  \u003C!-- -->\n\n  1. eGFR \\\u003C45 mL\u002Fmin\u002F1.73m² (regardless of albuminuria)\n  2. eGFR 45-59 mL\u002Fmin\u002F1.73m² with microalbuminuria (UACR 30-300 mg\u002Fg) or proteinuria (UACR \\>300 mg\u002Fg)\n  3. Microvascular disease in at least three sites (e.g., microalbuminuria, retinopathy, neuropathy)\n\nExclusion Criteria:\n\n* Type 1 diabetes or monogenic diabetes (e.g., MODY).\n* Pregnancy (self-reported).\n* Active cancer, under medical or radiation therapy or terminal, or cancer in remission \\\u003C 1 year.\n* Chronic immune or chronic infectious diseases.\n* End stage renal disease (ESRD) (estimated glomerular filtration rate \\\u003C15 mL\u002Fmin\u002F1.73m²).\n* Prisoners.\n* Inability or unwillingness to provide informed consent, including language barriers.\n* Mental incapacity.","ALL","18 Years",{"count":61,"type":62},3000,"ESTIMATED","5 Years","OBSERVATIONAL","Our objective is to create a cardiometabolic cohort that could be representative of the local population, consisting of Qataris and long-term residents, in order to identify the prevalence, risk factors, and clinical characteristics of cardiometabolic disorders, as well as the incidence of atherosclerotic cardiovascular disease events.",[67],"Cardiometabolic Diseases",[69,70,71],"cardiometabolic diseases","atherosclerotic cardiovascular disease","diabetes","NOT_YET_RECRUITING","2026-06-23",{"date":75,"type":76},"2026-06-30","ACTUAL",{"date":78,"type":62},"2026-06-01",{"date":80,"type":62},"2036-06-30",{"name":5,"class":6},1]