[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601867":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":24,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Main stent before branch balloon",null,"Patiens is allocated pot-hoc to this group if the operator performs the single stent in the main branch first and follows with balloon expansion in the ostium of the side branch. Angiography will be saved anonymously and sent to an independent core lab for µQFR calculation. Operaters are blinded to µQFR results. µQFR measurement will be repeated before and after intervention in both main and side branches.",{"label":13,"type":10,"description":14,"interventionNames":10},"Main stent after branch balloon","Patiens is allocated pot-hoc to this group if the operator performs expend the ostium of the side branch and then plants the single stent in the main branch. Angiography will be saved anonymously and sent to an independent core lab for µQFR calculation. Operaters are blinded to µQFR results. µQFR measurement will be repeated before and after intervention in both main and side branches.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Chenguang Li, MD, PhD","CONTACT","008664041990","li.chenguang@zs-hospital.sh.cn",{"name":22,"role":18,"phone":10,"phoneExt":10,"email":23},"Jinying Zhou, MD, PhD","zhou.jinying@zs-hospital.sh.cn",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Zhongshan Hospital, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200000","China","CN",{"type":34,"coordinates":35},"Point",[36,37],121.45806,31.22222,{"lat":37,"lon":36},[40],{"name":41,"role":18,"phone":42,"phoneExt":10,"email":23},"Chenguang l, MD, PhD","008602164041990",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Junbo Ge","Head of Department of Cardiology","100601867","qfr-for-branch-stenosis-after-single-stent-in-bifurcation-lesions-100601867",false,"NCT07116083","µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions","Diagnostic Performance of µQFR for Residual Functional Stenosis in Bifurcation Lesions After Single-stenting Strategy","Inclusion Criteria:\n\n1. Age ≥ 18 years and provision of written informed consent for biospecimen donation upon hospital admission.\n2. Clinical suspicion or diagnosis of CAD requiring coronary angiography and physiological assessment.\n3. Angiographically confirmed true bifurcation lesions, including but not limited to: left main-left anterior descending-left circumflex (LM-LAD-LCx), left anterior descending-diagonal (LAD-Dg), left circumflex-obtuse marginal (LCx-OM), and right coronary artery-posterior left ventricular-posterior descending artery (RCA-PLV-PDA).\n4. Bifurcation lesion vessel diameter ≥ 2.5 mm with visually estimated angiographic diameter stenosis ≥ 50%.\n\nExclusion Criteria:\n\n1. Acute myocardial infarction.\n2. Cardiogenic shock or severe heart failure (Killip class IV).\n3. Serum creatinine \\> 150 μmol\u002FL or estimated glomerular filtration rate (eGFR) \\\u003C 45 mL\u002Fmin\u002F1.73 m² calculated using the CKD-EPI formula.\n4. Known allergy to iodinated contrast media.\n5. History of coronary artery bypass graft surgery.","ALL","18 Years",{"count":57,"type":58},290,"ESTIMATED","OBSERVATIONAL","Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients. However, it's reliability has not been validated in bifurcation lesions which present complex anatomy and flluid conditions before and after PCI. The goal of this study is to investigate the diagnostic performance of µQFR in side branch after single-stent treatment for bifurcation lesions in patient with obstructive coronary artery diseases.",[62,63,64,65],"Coronary Artery Disease","Coronary Artery Disease (Left Main)","Obstructive Coronary Artery Disease","Stent Implantation",[67,68],"Functional Flow Reserve","Quantitative Flow Ratio","2026-01-28",{"date":71,"type":72},"2026-02-02","ACTUAL",{"date":74,"type":72},"2025-08-13",{"date":76,"type":58},"2026-10-31",{"name":5,"class":6},1]